Translational molecular imaging and drug development in Parkinson’s disease

Role of sex hormones in modulating myocardial perfusion and coronary flow reserve

(2022) Ahmed Haider et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Characterization in nonhuman primates of (R)-[18F]OF-Me-NB1 and (S)-[18F]OF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor

(2022) MingQiang Zheng et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates: (R)-[11C]NR2B-Me, (R)-[18F]of-Me-NB1, and (S)-[18F]of-NB1

(2022) Kelly Smart et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rest/stress myocardial perfusion imaging by positron emission tomography with 18F-Flurpiridaz: A feasibility study in mice

(2022) Susan Bengs et al.   JOURNAL OF NUCLEAR CARDIOLOGY

In vivo imaging of alpha-synuclein with antibody-based PET

(2022) Sahar Roshanbin et al.   NEUROPHARMACOLOGY

PET Molecular Imaging in Drug Development: The Imaging and Chemistry Perspective

(2022) Sridhar Goud Nerella et al.   Frontiers in Medicine

Molecular genetics of Parkinson’s disease: Contributions and global trends

(2022) Manabu Funayama et al.   JOURNAL OF HUMAN GENETICS

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors

(2022) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of (rac)-, (R)- and (S)-18F-OF-NB1 for imaging GluN2B subunit-containing N-methyl-D-aspartate receptors in non-human primates

(2022) Hazem Ahmed et al.   JOURNAL OF NUCLEAR MEDICINE

Trial of Prasinezumab in Early-Stage Parkinson’s Disease

(2022) Gennaro Pagano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

(2022) Danna Jennings et al.   Science Translational Medicine

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

(2022) Sahar Roshanbin et al.   Pharmaceutics

High‐Contrast Imaging of α‐Synuclein Pathologies in Living Patients with Multiple System Atrophy

(2022) Kiwamu Matsuoka et al.   MOVEMENT DISORDERS

Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand

(2022) Zhen Chen et al.   Journal of Medicinal Chemistry

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

(2021) Alex Iranzo et al.   LANCET NEUROLOGY

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease

(2021) Silvio R. Meier et al.   MOLECULAR IMAGING AND BIOLOGY

Novel targeted therapies for Parkinson’s disease

(2021) Theodora Ntetsika et al.   MOLECULAR MEDICINE

Parkinson's disease

(2021) Bastiaan R Bloem et al.   LANCET

Single Photon Emission Computed Tomography/Positron Emission Tomography Molecular Imaging for Parkinsonism: A Fast‐Developing Field

(2021) Antoine Verger et al.   ANNALS OF NEUROLOGY

First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas

(2021) Hiroyuki Fujimoto et al.   Frontiers in Endocrinology

The development of [ 18 F]ACI‐12589, a high affinity and selective alpha‐synuclein radiotracer, as a biomarker for Parkinson’s disease and other synucleinopathies

(2021) Francesca Capotosti et al.   Alzheimers & Dementia

Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand

(2021) Fabrice G. Siméon et al.   JOURNAL OF MEDICINAL CHEMISTRY

First-in-human brain PET imaging of the GluN2B-containing N-methyl-D-aspartate receptor with (R)-11C-Me-NB1

(2021) Lucas Rischka et al.   JOURNAL OF NUCLEAR MEDICINE

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

(2021) Eva Nordström et al.   NEUROBIOLOGY OF DISEASE

Fine Comparison of the Efficacy and Safety Between GB242 and Infliximab in Patients with Rheumatoid Arthritis: A Phase III Study

(2021) Yanying Liu et al.   Rheumatology and Therapy

Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system

(2020) Yan-Fei Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Soluble TREM2 is elevated in Parkinson’s disease subgroups with increased CSF tau

(2020) Edward N Wilson et al.   BRAIN

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

LRRK2 in Parkinson disease: challenges of clinical trials

(2020) Eduardo Tolosa et al.   Nature Reviews Neurology

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

(2020) Anke Van der Perren et al.   ACTA NEUROPATHOLOGICA

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

(2020) Mihalis S. Kariolis et al.   Science Translational Medicine

Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain

(2020) Michel Koole et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Preclinical Development of 18F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-D-Aspartate Receptors and its Utility as a Biomarker for Amyotrophic Lateral Sclerosis

(2020) Hazem Ahmed et al.   JOURNAL OF NUCLEAR MEDICINE

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

(2020) Hardy J. Rideout et al.   Frontiers in Neuroscience

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

(2020) Lingling Zhang et al.   Acta Pharmaceutica Sinica B

Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging

(2020) Sho Kaide et al.   ACS Chemical Neuroscience

Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein

(2020) Patricia Miranda-Azpiazu et al.   BRAIN RESEARCH

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

(2020) Laura Kuebler et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Development and biological evaluation of[18F]FMN3PA & [18F]FMN3PU for leucine-rich repeat kinase 2 (LRRK2) in vivo PET imaging

(2020) Noeen Malik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of Metabotropic Glutamate Receptors in Neurological Disorders

(2019) Rosalia Crupi et al.   Frontiers in Molecular Neuroscience

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Abnormal α -synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility

(2019) V Donadio et al.   EUROPEAN JOURNAL OF NEUROLOGY

α‐Synuclein real‐time quaking‐induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism

(2019) Anouke van Rumund et al.   ANNALS OF NEUROLOGY

New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease

(2019) Laura Best et al.   Current Neurology and Neuroscience Reports

Antibodies against alpha‐synuclein: tools and therapies

(2019) Nishant N. Vaikath et al.   JOURNAL OF NEUROCHEMISTRY

Synthesis and preliminary evaluation of [11C]GNE‐1023 as a novel potent PET probe for imaging leucine‐rich repeat kinase 2 (LRRK2) in Parkinson’s disease

(2019) Zhen Chen et al.   ChemMedChem

Alpha‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease

(2019) Zinah Wassouf et al.   JOURNAL OF NEUROCHEMISTRY

Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease

(2019) Samira Ztaou et al.   NEUROCHEMISTRY INTERNATIONAL

Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson’s Disease

(2019) Del Bello et al.   Biomolecules

TREM2 deficiency aggravates α-synuclein–induced neurodegeneration and neuroinflammation in Parkinson’s disease models

(2019) Ying Guo et al.   FASEB JOURNAL

Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism: a cross-sectional study

(2019) Heather Wilson et al.   LANCET NEUROLOGY

Impaired dopamine metabolism in Parkinson’s disease pathogenesis

(2019) Anna Masato et al.   Molecular Neurodegeneration

Structure–Affinity Relationships of 2,3,4,5-Tetrahydro-1H-3-benzazepine and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1H-3-benzazepine Congener for Imaging GluN2B Subunit-Containing N-Methyl-d-aspartate Receptors

(2019) Hazem Ahmed et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment

(2019) Zhichun Chen et al.   NEUROBIOLOGY OF DISEASE

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease

(2019) Carroll Rutherford Fields et al.   Frontiers in Molecular Neuroscience

Fluorinated GluN2B Receptor Antagonists with a 3-Benzazepine Scaffold Designed for PET Studies

(2018) Marina Szermerski et al.   ChemMedChem

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

GBA-Associated Parkinson’s Disease and Other Synucleinopathies

(2018) Ziv Gan-Or et al.   Current Neurology and Neuroscience Reports

TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing–remitting multiple sclerosis

(2018) Marcus Unterrainer et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic Target

(2018) Jinhua Chen et al.   EUROPEAN NEUROLOGY

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

(2018) Ahmed Haider et al.   JOURNAL OF NUCLEAR MEDICINE

Autonomic dysfunction in Parkinson's disease: The hidden game changer?

(2018) Eduardo De Pablo-Fernandez et al.   MOVEMENT DISORDERS

T156. IN VIVO CHARACTERIZATION OF THE FIRST AGONIST DOPAMINE D1 RECEPTORS PET IMAGING TRACER [18F]MNI-968 IN HUMAN

(2018) Gilles Tamagnan et al.   SCHIZOPHRENIA BULLETIN

FDG PET Parkinson’s disease-related pattern as a biomarker for clinical trials in early stage disease

(2018) Dawn C. Matthews et al.   NeuroImage-Clinical

Effect of overnight smoking abstinence on a marker for microglial activation: a [11C]DAA1106 positron emission tomography study

(2018) Arthur L. Brody et al.   PSYCHOPHARMACOLOGY

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

(2018) Andreas Weihofen et al.   NEUROBIOLOGY OF DISEASE

Striatal cholinergic interneurons and Parkinson's disease

(2017) Asami Tanimura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

(2017) Andrew B. West   EXPERIMENTAL NEUROLOGY

Pimavanserin: novel pharmacotherapy for Parkinson’s disease psychosis

(2017) Zeyad T. Sahli et al.   Expert Opinion on Drug Discovery

Evaluation of11C-Me-NB1 as a Potential PET Radioligand for Measuring GluN2B-Containing NMDA Receptors, Drug Occupancy, and Receptor Cross Talk

(2017) Stefanie D. Krämer et al.   JOURNAL OF NUCLEAR MEDICINE

18F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment

(2017) Philipp T. Meyer et al.   JOURNAL OF NUCLEAR MEDICINE

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

(2017) Dilan Athauda et al.   LANCET

Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder

(2017) Elena Antelmi et al.   NEUROLOGY

A new potential biomarker for dementia with Lewy bodies

(2017) Vincenzo Donadio et al.   NEUROLOGY

Neurotransmission systems in Parkinson’s disease

(2017) Hossein Sanjari Moghaddam et al.   REVIEWS IN THE NEUROSCIENCES

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

(2017) Shuchi Mittal et al.   SCIENCE

Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease

(2017) Eduardo De Pablo-Fernandez et al.   JAMA Neurology

Assessment of Safety and Efficacy of Safinamide as a Levodopa Adjunct in Patients With Parkinson Disease and Motor Fluctuations

(2017) Anthony H. V. Schapira et al.   JAMA Neurology

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

(2017) Hien Tran Zhao et al.   Molecular Therapy-Nucleic Acids

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Levodopa in Parkinson’s Disease: Current Status and Future Developments

(2017) Nicola Tambasco et al.   Current Neuropharmacology

Molecular imaging of dopamine transporters

(2016) David J. Brooks   AGEING RESEARCH REVIEWS

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice

(2016) Anna Migdalska-Richards et al.   ANNALS OF NEUROLOGY

Droxidopa and Reduced Falls in a Trial of Parkinson Disease Patients With Neurogenic Orthostatic Hypotension

(2016) Robert A. Hauser et al.   CLINICAL NEUROPHARMACOLOGY

Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation

(2016) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Glucagon-Like Peptide-1 Receptor PET/CT with 68Ga-NOTA-Exendin-4 for Detecting Localized Insulinoma: A Prospective Cohort Study

(2016) Y. Luo et al.   JOURNAL OF NUCLEAR MEDICINE

Building on 50 years of levodopa therapy

(2016) The Lancet Neurology   LANCET NEUROLOGY

Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

(2016) Joaquim J Ferreira et al.   LANCET NEUROLOGY

Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study

(2016) Marina Senek et al.   MOVEMENT DISORDERS

Effect of levodopa-carbidopa intestinal gel on dyskinesia in advanced Parkinson's disease patients

(2016) Angelo Antonini et al.   MOVEMENT DISORDERS

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease

(2016) Christopher H. Gibbons et al.   NEUROLOGY

Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinsons disease

(2016) M. M. Lipp et al.   Science Translational Medicine

Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease

(2015) Vincenzo Donadio et al.   ANNALS OF NEUROLOGY

Classification of Parkinsonian Syndromes from FDG-PET Brain Data Using Decision Trees with SSM/PCA Features

(2015) D. Mudali et al.   Computational and Mathematical Methods in Medicine

Catechol-O-Methyltransferase Inhibitors in Parkinson’s Disease

(2015) Thomas Müller   DRUGS

Use of 11C-PE2I PET in Differential Diagnosis of Parkinsonian Disorders

(2015) L. Appel et al.   JOURNAL OF NUCLEAR MEDICINE

Localization of Hidden Insulinomas with 68Ga-DOTA-Exendin-4 PET/CT: A Pilot Study

(2015) K. Antwi et al.   JOURNAL OF NUCLEAR MEDICINE

Parkinson’s disease: From human genetics to clinical trials

(2015) Marcel P. van der Brug et al.   Science Translational Medicine

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

(2015) Nicolas Maurice et al.   Cell Reports

Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference

(2015) Masaki Takahashi et al.   Molecular Therapy-Nucleic Acids

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Dopamine receptors - IUPHAR Review 13

(2014) Jean-Martin Beaulieu et al.   BRITISH JOURNAL OF PHARMACOLOGY

PET/SPECT imaging agents for neurodegenerative diseases

(2014) Lin Zhu et al.   CHEMICAL SOCIETY REVIEWS

Binding of the PET Radiotracer [18F]BF227 Does not Reflect the Presence of Alpha-Synuclein Aggregates in Transgenic Mice

(2014) Elise Levigoureux et al.   Current Alzheimer Research

Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

(2014) Markus Piel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Imaging Insights into Neurodegeneration: Focus on  -Synuclein Radiotracers

(2014) M. Shah et al.   JOURNAL OF NUCLEAR MEDICINE

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Novel formulations and modes of delivery of levodopa

(2014) Werner Poewe et al.   MOVEMENT DISORDERS

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

(2014) Veronica Lindström et al.   NEUROBIOLOGY OF DISEASE

Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease

(2014) Gurdal Sahin et al.   PLoS One

Correlation of Parkinson Disease Severity and18F-DTBZ Positron Emission Tomography

(2014) Ing-Tsung Hsiao et al.   JAMA Neurology

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein

(2014) Xiang Zhang et al.   Applied Sciences-Basel

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Oxidation and nitration of α-synuclein and their implications in neurodegenerative diseases

(2013) Cecilia Chavarría et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dopamine receptor agonists for Parkinson's disease

(2013) Fabio Blandini et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model

(2013) Vanesa Sanchez-Guajardo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Understanding cognitive deficits in Parkinson's disease: lessons from preclinical animal models

(2013) N. Solari et al.   LEARNING & MEMORY

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

(2013) Claudia Simões-Pires et al.   Molecular Neurodegeneration

The history of parkinsonism: Descriptions in ancient Indian medical literature

(2013) Sujith Ovallath et al.   MOVEMENT DISORDERS

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Immunogenicity of epitope vaccines targeting different B cell antigenic determinants of human α-synuclein: Feasibility study

(2013) Anahit Ghochikyan et al.   NEUROSCIENCE LETTERS

Diffusion-weighted imaging and its relationship to microglial activation in parkinsonian syndromes

(2013) Christopher Kobylecki et al.   PARKINSONISM & RELATED DISORDERS

MIBG myocardial scintigraphy in pre-motor Parkinson's disease: A review

(2013) Ryuji Sakakibara et al.   PARKINSONISM & RELATED DISORDERS

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

(2013) Devika P. Bagchi et al.   PLoS One

The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies

(2013) C. G. Goetz   Cold Spring Harbor Perspectives in Medicine

Multiclass classification of FDG PET scans for the distinction between Parkinson's disease and atypical parkinsonian syndromes

(2013) Gaëtan Garraux et al.   NeuroImage-Clinical

Synthesis and in vitro evaluation of α-synuclein ligands

(2012) Lihai Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Glutamate Receptors as Therapeutic Targets for Parkinsons Disease

(2012) Kari Johnson et al.   CNS & Neurological Disorders-Drug Targets

Phase II Safety and Clinical Comparison With Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease

(2012) Daniel S. Berman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

(2012) Koichi Wakabayashi et al.   MOLECULAR NEUROBIOLOGY

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

(2012) Nicola J. Ray et al.   NEUROBIOLOGY OF DISEASE

[18F]GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18kDa (TSPO)

(2011) Harry Wadsworth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis

(2011) Giorgio Treglia et al.   CLINICAL AUTONOMIC RESEARCH

Monoamine Oxidase B Inhibitors for the Treatment of Parkinsonʼs Disease

(2011) Anthony H.V. Schapira   CNS DRUGS

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations

(2011) Jae Hyuk Choi et al.   MOLECULAR GENETICS AND METABOLISM

The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease

(2011) Susan H. Fox et al.   MOVEMENT DISORDERS

Amantadine for Dyskinesias in Parkinson's Disease: A Randomized Controlled Trial

(2011) Hideyuki Sawada et al.   PLoS One

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Acetylcholine-dopamine balance hypothesis in the striatum: An update

(2010) Toshihiko Aosaki et al.   Geriatrics & Gerontology International

A brief history of levodopa

(2010) Oleh Hornykiewicz   JOURNAL OF NEUROLOGY

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

In Vivo Measurement of Vesicular Monoamine Transporter Type 2 Density in Parkinson Disease with 18F-AV-133

(2010) N. Okamura et al.   JOURNAL OF NUCLEAR MEDICINE

123I-metaiodobenzylguanidine scintigraphy in Parkinson's disease and related disorders

(2010) Olivier Rascol et al.   MOVEMENT DISORDERS

Levodopa: the story so far

(2010) Alison Abbott   NATURE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo 11C-DASB PET study

(2010) Marios Politis et al.   NEUROBIOLOGY OF DISEASE

Visualization of early infarction in rat brain after ischemia using a translocator protein (18kDa) PET ligand [11C]DAC with ultra-high specific activity

(2010) Joji Yui et al.   NEUROIMAGE

Levodopa in the treatment of Parkinson’s disease: an old drug still going strong

(2010) Angelo Antonini   Clinical Interventions in Aging

In vitro characterisation of BF227 binding to α-synuclein/Lewy bodies

(2009) Michelle T. Fodero-Tavoletti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Levodopa: Past, Present, and Future

(2009) Robert A. Hauser   EUROPEAN NEUROLOGY

Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation

(2009) F. Chauveau et al.   JOURNAL OF NUCLEAR MEDICINE

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia

(2008) Joohyung Lee et al.   BRAIN

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

(2008) Filip Simunovic et al.   BRAIN

A review of Parkinson's disease

(2008) C. A. Davie   BRITISH MEDICAL BULLETIN

Molecular Imaging with PET

(2008) Simon M. Ametamey et al.   CHEMICAL REVIEWS

Psychiatric symptoms in Parkinson’s disease

(2008) Frank Schneider et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

In vitro high affinity α-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain

(2008) Liang Ye et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

In vivo silencing of alpha-synuclein using naked siRNA

(2008) Jada Lewis et al.   Molecular Neurodegeneration

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

(2008) R.J. Phillips et al.   NEUROSCIENCE

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology

Technology Insight: imaging neurodegeneration in Parkinson's disease

(2008) David J Brooks   Nature clinical practice. Neurology

Axonal  -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

(2007) S. Orimo et al.   BRAIN