Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

(2020) Julie C. Ullman et al.   Science Translational Medicine

Engineering of binding functions into proteins

(2019) Michaela Gebauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration

(2018) Denise Karaoglu Hanzatian et al.   mAbs

Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26

(2018) George Thom et al.   MOLECULAR PHARMACEUTICS

A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II

(2018) Hiroyuki Sonoda et al.   MOLECULAR THERAPY

Passive immunotherapies for central nervous system disorders – current delivery challenges and new approaches.

(2018) Niyanta N. Kumar et al.   BIOCONJUGATE CHEMISTRY

Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics

(2018) Katy L. Everett et al.   METHODS

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

(2017) Megan Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

(2017) Carl I. Webster et al.   PAIN

Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments

(2017) Gordana Wozniak-Knopp et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineered IgG1-Fc - one fragment to bind them all

(2016) Elisabeth Lobner et al.   IMMUNOLOGICAL REVIEWS

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy

(2015) Jonathan T. Sockolosky et al.   ADVANCED DRUG DELIVERY REVIEWS

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis

(2015) Kin-Mei Leung et al.   MOLECULAR THERAPY

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Engineered Fc based antibody domains and fragments as novel scaffolds

(2014) Tianlei Ying et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites

(2014) Max Woisetschläger et al.   Biotechnology Journal

Recent Advances in Delivery Through the Blood-Brain Barrier

(2014) Jessica Larsen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Open questions for Alzheimer’s disease immunotherapy

(2014) Todd E Golde   Alzheimers Research & Therapy

Brain Bioavailability of Human Intravenous Immunoglobulin and its Transport through the Murine Blood–Brain Barrier

(2013) Isabelle St-Amour et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

(2013) Daniel J. Wolak et al.   MOLECULAR PHARMACEUTICS

Developing Therapeutic Antibodies for Neurodegenerative Disease

(2013) Y. Joy Yu et al.   Neurotherapeutics

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Integrin binding human antibody constant domains—Probing the C-terminal structural loops for grafting the RGD motif

(2011) Michael W. Traxlmayr et al.   JOURNAL OF BIOTECHNOLOGY

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties

(2010) G. Wozniak-Knopp et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Highly avid magnetic bead capture: An efficient selection method for de novo protein engineering utilizing yeast surface display

(2009) Margaret Ackerman et al.   BIOTECHNOLOGY PROGRESS

Macromolecular drug transport into the brain using targeted therapy

(2009) Jacek Lichota et al.   JOURNAL OF NEUROCHEMISTRY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE