Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

In vivo imaging of alpha-synuclein with antibody-based PET

(2022) Sahar Roshanbin et al.   NEUROPHARMACOLOGY

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease

(2021) Silvio R. Meier et al.   MOLECULAR IMAGING AND BIOLOGY

Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice

(2021) Sahar Roshanbin et al.   NEUROBIOLOGY OF AGING

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

(2021) Rebecca Faresjö et al.   Fluids and Barriers of the CNS

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

(2020) Tobias Gustavsson et al.   Translational Neurodegeneration

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

(2020) Stina Syvänen et al.   ACS Chemical Neuroscience

How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology

(2020) Senthil T. Kumar et al.   NEUROBIOLOGY OF DISEASE

Increased immune activation by pathologic alpha‐synuclein in Parkinson's Disease

(2019) Veselin Grozdanov et al.   ANNALS OF NEUROLOGY

The concept of alpha-synuclein as a prion-like protein: ten years after

(2018) Jennifer A. Steiner et al.   CELL AND TISSUE RESEARCH

Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes

(2018) Carmen Mecca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antibody pharmacokinetics in rat brain determined using microdialysis

(2018) Hsueh-Yuan Chang et al.   mAbs

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

(2018) Stina Syvänen et al.   Alzheimers Research & Therapy

Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease

(2018) Joseph Jankovic et al.   JAMA Neurology

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

(2018) Changyoun Kim et al.   Molecular Neurodegeneration

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

(2018) Andreas Weihofen et al.   NEUROBIOLOGY OF DISEASE

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

(2017) Greta Hultqvist et al.   Theranostics

Revisiting nanoparticle technology for blood–brain barrier transport: Unfolding at the endothelial gate improves the fate of transferrin receptor-targeted liposomes

(2016) Kasper Bendix Johnsen et al.   JOURNAL OF CONTROLLED RELEASE

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

α -synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease

(2016) Brian Spencer et al.   Annals of Clinical and Translational Neurology

Reducing Adsorption To Improve Recovery and in Vivo Detection of Neuropeptides by Microdialysis with LC-MS

(2015) Ying Zhou et al.   ANALYTICAL CHEMISTRY

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

(2014) Brian Spencer et al.   MOLECULAR THERAPY

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

(2014) Veronica Lindström et al.   NEUROBIOLOGY OF DISEASE

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Functional roles of transferrin in the brain

(2011) Dominique F. Leitner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

The cholinergic system and Parkinson disease

(2010) Nicolaas I. Bohnen et al.   BEHAVIOURAL BRAIN RESEARCH

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

The role of high-dose intravenous immunoglobulin in rheumatology

(2010) P. M. Vaitla et al.   RHEUMATOLOGY

Levodopa in the treatment of Parkinson’s disease

(2009) A. H. V. Schapira et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING