The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
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Title
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
Authors
Keywords
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Journal
ACTA NEUROPATHOLOGICA
Volume 139, Issue 6, Pages 977-1000
Publisher
Springer Science and Business Media LLC
Online
2020-04-30
DOI
10.1007/s00401-020-02157-3
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Note: Only part of the references are listed.- Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs
- (2020) Amulya Nidhi Shrivastava et al. BIOPHYSICAL JOURNAL
- Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
- (2020) Mohammad Shahnawaz et al. NATURE
- Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
- (2019) Simona Gribaudo et al. Stem Cell Reports
- Seeding Variability of Different Alpha Synuclein Strains in Synucleinopathies
- (2019) Niccolò Candelise et al. ANNALS OF NEUROLOGY
- Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
- (2019) Jichao Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased immune activation by pathologic alpha‐synuclein in Parkinson's Disease
- (2019) Veselin Grozdanov et al. ANNALS OF NEUROLOGY
- Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification
- (2019) Alexis Fenyi et al. NEUROBIOLOGY OF DISEASE
- Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
- (2019) Zachary A. Sorrentino et al. Acta Neuropathologica Communications
- α-Synuclein strains target distinct brain regions and cell types
- (2019) Angus Lau et al. NATURE NEUROSCIENCE
- Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
- (2019) Timo Strohäker et al. Nature Communications
- Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
- (2018) Chao Peng et al. NATURE
- Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces
- (2018) Alexis Fenyi et al. Scientific Reports
- Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
- (2018) Jessika C. Bridi et al. Frontiers in Neuroscience
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
- (2017) Poonam Thakur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- (2016) Francois-Xavier Theillet et al. NATURE
- A novel link between the conformations, exposure of specific epitopes, and subcellular localization of α-synuclein
- (2015) Min-Kyung Nam et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- -synuclein assemblies sequester neuronal 3-Na+/K+-ATPase and impair Na+ gradient
- (2015) A. N. Shrivastava et al. EMBO JOURNAL
- MDS clinical diagnostic criteria for Parkinson's disease
- (2015) Ronald B. Postuma et al. MOVEMENT DISORDERS
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors
- (2015) Anke Van der Perren et al. NEUROBIOLOGY OF AGING
- FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease
- (2015) Anke Van der Perren et al. NEUROBIOLOGY OF AGING
- Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
- (2015) Stanley B. Prusiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
- (2015) Maria E. Bernis et al. Acta Neuropathologica Communications
- α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling
- (2014) Lina Wang et al. CURRENT BIOLOGY
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells
- (2012) Laura Pieri et al. BIOPHYSICAL JOURNAL
- Association between Parkinson's disease and the HLA-DRB1 locus
- (2012) Ismaïl Ahmed et al. MOVEMENT DISORDERS
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9
- (2011) A Van der Perren et al. GENE THERAPY
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy
- (2011) Z. Sultana et al. NEUROSCIENCE
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Seeded Aggregation and Toxicity of α-Synuclein and Tau
- (2010) Takashi Nonaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium
- (2009) Irina Alafuzoff et al. ACTA NEUROPATHOLOGICA
- Detection of elevated levels of soluble -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
- (2009) K. E. Paleologou et al. BRAIN
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium
- (2008) Irina Alafuzoff et al. BRAIN PATHOLOGY
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Second consensus statement on the diagnosis of multiple system atrophy
- (2008) S. Gilman et al. NEUROLOGY
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