The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease
Authors
Keywords
-
Journal
JOURNAL OF NEUROCHEMISTRY
Volume 137, Issue 3, Pages 331-359
Publisher
Wiley
Online
2016-02-07
DOI
10.1111/jnc.13570
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
- (2016) Timothy J. Collier et al. Frontiers in Neuroscience
- α-synuclein pathology accumulates in sacral spinal visceral sensory pathways
- (2015) Veronique G. VanderHorst et al. ANNALS OF NEUROLOGY
- shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model
- (2015) Alevtina D. Zharikov et al. JOURNAL OF CLINICAL INVESTIGATION
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
- (2015) Ulf Dettmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- The Newly Discovered Parkinson’s Disease Associated Finnish Mutation (A53E) Attenuates α-Synuclein Aggregation and Membrane Binding
- (2014) Dhiman Ghosh et al. BIOCHEMISTRY
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases
- (2014) He-Jin Lee et al. Nature Reviews Neurology
- Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?
- (2014) Katerina Markopoulou et al. PARKINSONISM & RELATED DISORDERS
- Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells
- (2014) Javier Vargas-Medrano et al. ACS Medicinal Chemistry Letters
- SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese
- (2013) Nan-Nan Li et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro
- (2013) Dhiman Ghosh et al. BIOCHEMISTRY
- Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
- (2013) Jeffrey H. Kordower et al. BRAIN
- In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells
- (2013) Ulf Dettmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function
- (2013) Kaitlin F. Farrell et al. JOURNAL OF NEUROCHEMISTRY
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease
- (2013) Dorota Hoffman-Zacharska et al. PARKINSONISM & RELATED DISORDERS
- Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System
- (2013) Sara E. Gombash et al. PLoS One
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
- (2012) Meret Nora Gaugler et al. ACTA NEUROPATHOLOGICA
- Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells
- (2012) Laura Pieri et al. BIOPHYSICAL JOURNAL
- α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
- (2012) Joseph G. Quinn et al. BRAIN RESEARCH
- α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
- (2012) Tito Calì et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1
- (2012) X. Lin et al. JOURNAL OF NEUROSCIENCE
- -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
- (2012) D. Scott et al. JOURNAL OF NEUROSCIENCE
- Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
- (2012) J. Burre et al. JOURNAL OF NEUROSCIENCE
- Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases
- (2012) Kathleen M. Shannon et al. MOVEMENT DISORDERS
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits
- (2012) Penelope J. Hallett et al. NEUROBIOLOGY OF DISEASE
- Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system
- (2012) Ali Reza Noorian et al. NEUROBIOLOGY OF DISEASE
- Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo
- (2012) J. Wu et al. NEUROSCIENCE
- Aggregation of -synuclein is kinetically controlled by intramolecular diffusion
- (2012) B. Ahmad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons
- (2011) Ye Han et al. BRAIN RESEARCH
- An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons
- (2011) Christina E. Khodr et al. BRAIN RESEARCH
- The role of the C-terminus of human α-synuclein: Intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers
- (2011) Dong-Pyo Hong et al. FEBS LETTERS
- Membrane Curvature Sensing by Amphipathic Helices
- (2011) Martin Borch Jensen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sumoylation inhibits α-synuclein aggregation and toxicity
- (2011) Petranka Krumova et al. JOURNAL OF CELL BIOLOGY
- Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
- (2011) Qi Xuan et al. JOURNAL OF NEURAL TRANSMISSION
- Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression
- (2011) Jesse R. McLean et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
- (2011) Kathleen M. Shannon et al. MOVEMENT DISORDERS
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates
- (2011) Timothy J. Collier et al. NATURE REVIEWS NEUROSCIENCE
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- The Many Faces of Tau
- (2011) Meaghan Morris et al. NEURON
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- (2010) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease
- (2010) Todd L. Edwards et al. ANNALS OF HUMAN GENETICS
- Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles
- (2010) Elizabeth R. Middleton et al. BIOPHYSICAL JOURNAL
- Overexpression of α-Synuclein Down-Regulates BDNF Expression
- (2010) Yuhe Yuan et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes
- (2010) Yien-Ming Kuo et al. HUMAN MOLECULAR GENETICS
- Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2Ain Vitroandin Vivo
- (2010) Haiyan Lou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors
- (2010) K. Ubhi et al. JOURNAL OF NEUROSCIENCE
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility
- (2010) Vivek K. Unni et al. PLoS One
- α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
- (2010) Alison L. McCormack et al. PLoS One
- -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
- (2010) B. Greten-Harrison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- α-Synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells
- (2009) Fengxia Wu et al. BRAIN RESEARCH
- Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein
- (2009) Vladimir Uversky et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Decreased α-synuclein expression in the aging mouse substantia nigra
- (2009) Sally K. Mak et al. EXPERIMENTAL NEUROLOGY
- Expansion of the Parkinson disease-associated SNCA- Rep1 allele upregulates human α-synuclein in transgenic mouse brain
- (2009) Kenneth D. Cronin et al. HUMAN MOLECULAR GENETICS
- 14-3-3ζ Contributes to Tyrosine Hydroxylase Activity in MN9D Cells
- (2009) Jian Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Abnormal colonic motility in mice overexpressing human wild-type α-synuclein
- (2009) Lixin Wang et al. NEUROREPORT
- Neuropathology of non-motor features of Parkinson disease
- (2009) Dennis W. Dickson et al. PARKINSONISM & RELATED DISORDERS
- Genetic Regulation of α-Synuclein mRNA Expression in Various Human Brain Tissues
- (2009) Colton Linnertz et al. PLoS One
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Is Parkinson's disease a prion disorder?
- (2009) C. W. Olanow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A critical reappraisal of current staging of Lewy-related pathology in human brain
- (2008) Kurt A. Jellinger ACTA NEUROPATHOLOGICA
- Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
- (2008) Dennis W. Dickson et al. ACTA NEUROPATHOLOGICA
- Patients Homozygous and Heterozygous for SNCA Duplication in a Family With Parkinsonism and Dementia
- (2008) Takeshi Ikeuchi et al. ARCHIVES OF NEUROLOGY
- Sequence determinants regulating fibrillation of human α-synuclein
- (2008) Hyun-Jung Koo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA — A key player in the pathogenesis of Parkinson's disease
- (2008) Karina Häbig et al. BRAIN RESEARCH
- The effect of α-synuclein knockdown on MPP+ toxicity in models of human neurons
- (2008) Timothy M. Fountaine et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Olfactory deficits in mice overexpressing human wildtype -synuclein
- (2008) Sheila M. Fleming et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Assembly-dependent endocytosis and clearance of extracellular a-synuclein
- (2008) He-Jin Lee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease
- (2008) Shaji Theodore et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- In vivo silencing of alpha-synuclein using naked siRNA
- (2008) Jada Lewis et al. Molecular Neurodegeneration
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice
- (2008) Abdelmojib Al-Wandi et al. NEUROBIOLOGY OF AGING
- Silencing α-Synuclein Gene Expression Enhances Tyrosine Hydroxylase Activity in MN9D Cells
- (2008) Dongmei Liu et al. NEUROCHEMICAL RESEARCH
- Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood
- (2008) Robin Barbour et al. Neurodegenerative Diseases
- α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice
- (2008) Tshianda N.M. Alerte et al. NEUROSCIENCE LETTERS
- Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease
- (2008) Jan Gründemann et al. NUCLEIC ACIDS RESEARCH
- Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain
- (2007) Julia Fuchs et al. FASEB JOURNAL
- Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
- (2006) Masaki Wakamatsu et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More