Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice

Adipose-tissue plasticity in health and disease

(2022) Alexander Sakers et al.   CELL

SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

(2022) Gung Lee et al.   Cell Metabolism

AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p

(2022) Jinjiang Chou et al.   Molecular Cancer

Transfer of microRNA-22-3p by M2 macrophage-derived extracellular vesicles facilitates the development of ankylosing spondylitis through the PER2-mediated Wnt/β-catenin axis

(2022) Chong Liu et al.   Cell Death Discovery

The miRNA‐143‐3p–Sox6–Myh7 pathway is altered in obesogenic diet‐induced cardiac hypertrophy

(2022) Tábatha de Oliveira Silva et al.   EXPERIMENTAL PHYSIOLOGY

Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose Cells

(2022) Birgit Gustafson et al.   DIABETES

Sodium hydrosulfide alleviates dexamethasone‑induced cell senescence and dysfunction through targeting the miR‑22/sirt1 pathway in osteoblastic MC3T3‑E1 cells

(2021) Peng Li et al.   Experimental and Therapeutic Medicine

Cellular senescence and its role in white adipose tissue

(2021) Ulf Smith et al.   INTERNATIONAL JOURNAL OF OBESITY

Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis

(2021) Yamei Zhang et al.   Stem Cell Research & Therapy

microRNA‐22‐3p plays a protecting role in a murine asthma model through the inhibition of the NLRP3/Caspase‐1/IL‐1β axis

(2021) Shufang Guo et al.   EXPERIMENTAL PHYSIOLOGY

miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation

(2021) Vanessa M. Lima et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

(2021) Laura Le Pelletier et al.   eLife

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

(2021) Lichao Wang et al.   Cell Metabolism

MicroRNA-22 inhibition promotes the development of atherosclerosis via targeting interferon regulator factor 5

(2021) Zhenhua Wu et al.   EXPERIMENTAL CELL RESEARCH

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

(2021) Qian Li et al.   NATURE MEDICINE

miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes

(2021) Allancer D. C. Nunes et al.   GeroScience

The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders

(2020) Zhuohao Liu et al.   CLINICAL SCIENCE

Obesity and ageing: Two sides of the same coin

(2020) Bjorn T. Tam et al.   Obesity Reviews

In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans

(2020) Cory M. Dungan et al.   FASEB JOURNAL

MiR-483 induces senescence of human adipose-derived mesenchymal stem cells through IGF1 inhibition

(2020) Junyan Shen et al.   Aging-US

Inhibition of miR-34a reduces cellular senescence in human adipose tissue-derived mesenchymal stem cells through the activation of SIRT1

(2020) Neda Mokhberian et al.   LIFE SCIENCES

Metabolic and energetic benefits of microRNA-22 inhibition

(2020) Marc Thibonnier et al.   BMJ Open Diabetes Research & Care

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision

(2019) Cheng-Yuan Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway

(2019) Gen-Xiang Mao et al.   Oxidative Medicine and Cellular Longevity

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration

(2018) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Obesity: Trends in underweight and obesity — scale of the problem

(2017) Jack A. Yanovski   Nature Reviews Endocrinology

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

(2016) Bastien Vergoni et al.   DIABETES

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

(2016) Shashi Kumar Gupta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1

(2015) J.-H. Lee et al.   CANCER RESEARCH

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

(2015) Yih-Wen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

MicroRNA-22 Induces Endothelial Progenitor Cell Senescence by Targeting AKT3

(2014) Yue Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

The roles of senescence and telomere shortening in cardiovascular disease

(2013) Frej Fyhrquist et al.   Nature Reviews Cardiology

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart

(2012) Virginija Jazbutyte et al.   AGE

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

(2012) Marcelo A. Mori et al.   Cell Metabolism

Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21

(2011) N. Tsuchiya et al.   CANCER RESEARCH

A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts

(2011) R Faraonio et al.   CELL DEATH AND DIFFERENTIATION

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

Association of Telomere Length in Older Men With Mortality and Midlife Body Mass Index and Smoking

(2011) T. E. Strandberg et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the γ-H2AX focus assay and micronucleus test

(2010) Roberto Scarpato et al.   FASEB JOURNAL

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Connecting obesity, aging and diabetes

(2009) Rexford S. Ahima   NATURE MEDICINE

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols