In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans

Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors

(2020) Yuki Saito et al.   Nature Communications

Hsp90β interacts with MDM2 to suppress p53‐dependent senescence during skeletal muscle regeneration

(2019) Min Yi He et al.   AGING CELL

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

(2019) Angela E. M. Ibler et al.   Nature Communications

Aged cells in human skeletal muscle after resistance exercise

(2018) Chi Yang et al.   Aging-US

MyoVision: software for automated high-content analysis of skeletal muscle immunohistochemistry

(2018) Yuan Wen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

(2018) Frédéric Lessard et al.   NATURE CELL BIOLOGY

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes

(2018) Nicoletta Marroncelli et al.   Scientific Reports

Altered DNA repair; an early pathogenic pathway in Alzheimer’s disease and obesity

(2018) Hao Yu et al.   Scientific Reports

EBV persistence without its EBNA3A and 3C oncogenes in vivo

(2018) Anita Murer et al.   PLoS Pathogens

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women

(2017) Jamie N Justice et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Quantification and characterization of grouped type I myofibers in human aging

(2017) Neil A. Kelly et al.   MUSCLE & NERVE

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

(2017) Alexis R. Barr et al.   Nature Communications

Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo

(2017) Cindy T.J. van Velthoven et al.   Cell Reports

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

(2016) Servet Özcan et al.   Aging-US

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

(2016) Alexandra Bernadotte et al.   Aging-US

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

Identification of Senescent Cells in the Bone Microenvironment

(2016) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

(2016) Aleksandra Borodkina et al.   Aging-US

Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus

(2016) Zhi-Yong He et al.   Scientific Reports

P21 Deficiency Delays Regeneration of Skeletal Muscular Tissue

(2015) Nobuaki Chinzei et al.   PLoS One

Age-Associated Methylation Suppresses SPRY1 , Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle

(2015) Anne Bigot et al.   Cell Reports

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Satellite cells in human skeletal muscle; from birth to old age

(2013) Lex B. Verdijk et al.   AGE

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

(2013) Pura Muñoz-Cánoves et al.   FEBS Journal

Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

(2013) P.M. Coen et al.   Obesity

Regenerative Capacity of Old Muscle Stem Cells Declines without Significant Accumulation of DNA Damage

(2013) Wendy Cousin et al.   PLoS One

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity

(2012) P Fortini et al.   CELL DEATH AND DIFFERENTIATION

The ConsensusPathDB interaction database: 2013 update

(2012) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence

(2011) Paola Perucca et al.   CELL CYCLE

Chronic low-grade inflammation and age-related sarcopenia

(2011) Ingo Beyer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

PAI-1 in tissue fibrosis

(2011) Asish K. Ghosh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Early Life Nutrition Modulates Muscle Stem Cell Number: Implications for Muscle Mass and Repair

(2011) Melissa Woo et al.   STEM CELLS AND DEVELOPMENT

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet

(2010) Z. Hu et al.   DIABETES

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Plasminogen Activator Inhibitor Type 1 Up-Regulation Is Associated with Skeletal Muscle Atrophy and Associated Fibrosis

(2009) Jasmin Naderi et al.   AMERICAN JOURNAL OF PATHOLOGY

Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance

(2009) M. E. Gazzar et al.   MOLECULAR AND CELLULAR BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

(2009) C.-Y. Wang et al.   Science Signaling

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

(2007) Ranganath Muniyappa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM