SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

(2020) Agian Jeffilano Barinda et al.   Nature Communications

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

(2019) Michele Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity May Accelerate the Aging Process

(2019) Valentina Salvestrini et al.   Frontiers in Endocrinology

GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity

(2019) Injae Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

(2019) Birgit Gustafson et al.   Nature Communications

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity

(2019) Jeu Park et al.   GENES & DEVELOPMENT

SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy

(2018) Xiang Cheng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Role of sphingolipids in senescence: implication in aging and age-related diseases

(2018) Magali Trayssac et al.   JOURNAL OF CLINICAL INVESTIGATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

(2018) Ali Talebi et al.   Nature Communications

Dna is a New Target of Parp3

(2018) E. A. Belousova et al.   Scientific Reports

Dynamics of adipose tissue turnover in human metabolic health and disease

(2018) Ursula White et al.   DIABETOLOGIA

Perilipin 1 (Plin1) deficiency promotes inflammatory responses in lean adipose tissue through lipid dysregulation

(2018) Jee Hyung Sohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress

(2018) Gung Lee et al.   DIABETES

Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium

(2018) Qingqiu Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen Peroxide-Induced DNA Damage and Repair through the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

(2018) Mahara Valverde et al.   Stem Cells International

Regulation of lipids is central to replicative senescence

(2017) Darleny Y. Lizardo et al.   Molecular BioSystems

Network propagation: a universal amplifier of genetic associations

(2017) Lenore Cowen et al.   NATURE REVIEWS GENETICS

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

(2016) Bastien Vergoni et al.   DIABETES

Protein Kinase A Subunit Balance Regulates Lipid Metabolism inCaenorhabditis elegansand Mammalian Adipocytes

(2016) Jung Hyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Foxp3 is a key downstream regulator of p53-mediated cellular senescence

(2016) J-E Kim et al.   ONCOGENE

BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells

(2016) S V Muralidharan et al.   ONCOGENE

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

(2016) Joe Nassour et al.   Nature Communications

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

(2016) Hagoon Jang et al.   Nature Communications

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

SREBP and MDT-15 protectC. elegansfrom glucose-induced accelerated aging by preventing accumulation of saturated fat

(2015) Dongyeop Lee et al.   GENES & DEVELOPMENT

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Function of transcription factors at DNA lesions in DNA repair

(2014) Michal Malewicz et al.   EXPERIMENTAL CELL RESEARCH

Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation

(2014) Jae Ho Lee et al.   HEPATOLOGY

Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity

(2014) Masataka Yokoyama et al.   Cell Reports

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

(2011) Sebastian Eustermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

(2011) W.-C. Huang et al.   MOLECULAR CANCER RESEARCH

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

PARP1 deficiency exacerbates diet-induced obesity in mice

(2010) Kishor Devalaraja-Narashimha et al.   JOURNAL OF ENDOCRINOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inflammatory signaling and cellular senescence

(2008) Jian-Lin Ren et al.   CELLULAR SIGNALLING

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE