Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

(2019) Matthew J. Harms et al.   Cell Reports

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

(2019) Birgit Gustafson et al.   Nature Communications

Adipose lipid turnover and long-term changes in body weight

(2019) P. Arner et al.   NATURE MEDICINE

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

(2019) Xiaohui Bian et al.   BMJ Open Diabetes Research & Care

Mammalian endoreplication emerges to reveal a potential developmental timer

(2018) Alberto Gandarillas et al.   CELL DEATH AND DIFFERENTIATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

(2018) Dominick G. A. Burton et al.   BIOGERONTOLOGY

The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy

(2018) Zhuohao Liu et al.   DIABETES

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity

(2018) Ann Hammarstedt et al.   PHYSIOLOGICAL REVIEWS

Persistent repair intermediates induce senescence

(2018) F. M. Feringa et al.   Nature Communications

Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity

(2018) Carolina E. Hagberg et al.   Cell Reports

Rapamycin, proliferation and geroconversion to senescence

(2018) Mikhail V. Blagosklonny   CELL CYCLE

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Cardiovascular risk score is linked to subcutaneous adipocyte size and lipid metabolism

(2017) M. Rydén et al.   JOURNAL OF INTERNAL MEDICINE

CDK4/6 inhibition triggers anti-tumour immunity

(2017) Shom Goel et al.   NATURE

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

(2016) Bastien Vergoni et al.   DIABETES

The cell fate: senescence or quiescence

(2016) Menderes Yusuf Terzi et al.   MOLECULAR BIOLOGY REPORTS

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

(2016) Per Hydbring et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis

(2015) Mikael Rydén et al.   Cell Metabolism

CDK4 is an essential insulin effector in adipocytes

(2015) Sylviane Lagarrigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

(2015) Yih-Wen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When bigger is better: the role of polyploidy in organogenesis

(2015) Terry L. Orr-Weaver   TRENDS IN GENETICS

Nuclear DNA Content Varies with Cell Size across Human Cell Types

(2015) James F. Gillooly et al.   Cold Spring Harbor Perspectives in Biology

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth

(2014) Bruce A. Edgar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polyploidization in Liver Tissue

(2013) Géraldine Gentric et al.   AMERICAN JOURNAL OF PATHOLOGY

γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway

(2013) Wen-Zhi Tu et al.   FEBS LETTERS

Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes

(2013) Finny Monickaraj et al.   JOURNAL OF BIOSCIENCES

Fundamental differences in endoreplication in mammals andDrosophilarevealed by analysis of endocycling and endomitotic cells

(2013) Noa Sher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance

(2012) Giuseppe Murdolo et al.   BIOCHIMIE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle

(2012) Michael Hesse et al.   Nature Communications

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide

(2011) H. Matsui-Hirai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Adipokines as novel biomarkers and regulators of the metabolic syndrome

(2010) Yingfeng Deng et al.   Annals of the New York Academy of Sciences

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity

(2010) J. Hoffstedt et al.   DIABETOLOGIA

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

ConsensusPathDB: toward a more complete picture of cell biology

(2010) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin

(2009) Yulia A. Nevzorova et al.   GASTROENTEROLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

(2009) Daniel Ramsköld et al.   PLoS Computational Biology

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Inflated beta distributions

(2008) Raydonal Ospina et al.   STATISTICAL PAPERS