AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

(2021) Amina Iftekhar et al.   Nature Communications

Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die

(2021) Matthew Man-Kin Wong et al.   Cancers

Integrated approaches for precision oncology in colorectal cancer: The more you know, the better

(2021) Pietro Andrei et al.   SEMINARS IN CANCER BIOLOGY

The long journey to bring a Myc inhibitor to the clinic

(2021) Jonathan R. Whitfield et al.   JOURNAL OF CELL BIOLOGY

Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer

(2021) Sophie L. Boos et al.   Cellular and Molecular Gastroenterology and Hepatology

MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer

(2020) Juan Xu et al.   Molecular Cancer

The DNA damage response pathway as a land of therapeutic opportunities for colorectal cancer

(2020) G. Mauri et al.   ANNALS OF ONCOLOGY

Loss of MDC1 in Endometrial Carcinoma Is Associated With Loss of MRN Complex and MMR Deficiency

(2019) DANAE MERENTITIS et al.   ANTICANCER RESEARCH

AP4 positively regulates LAPTM4B to promote hepatocellular carcinoma growth and metastasis, while reducing chemotherapy sensitivity

(2018) Yue Meng et al.   Molecular Oncology

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

(2018) Stephanie Jaeckel et al.   Nature Communications

Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53‐ROS‐Mitochondrial Pathway

(2017) Zhihai Wang et al.   ONCOLOGY RESEARCH

AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin

(2017) Changhao Chen et al.   Cell Death & Disease

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

(2017) Claudio Isella et al.   Nature Communications

dUTPase inhibition augments replication defects of 5-Fluorouracil

(2017) Anna Hagenkort et al.   Oncotarget

The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses

(2016) Chun Chou et al.   IMMUNITY

Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells

(2016) Quan Zeng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1

(2015) J.-H. Lee et al.   CANCER RESEARCH

Pharmacogenomic agreement between two cancer cell line data sets

(2015) Nicolas Stransky et al.   NATURE

Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition

(2015) Z Wang et al.   Cell Death & Disease

AP4 is required for mitogen- and c-MYC-induced cell cycle progression

(2015) Rene Jackstadt et al.   Oncotarget

c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells

(2014) Chun Chou et al.   NATURE IMMUNOLOGY

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer

(2013) Rene Jackstadt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

DNA damage associated with mitosis and cytokinesis failure

(2013) M T Hayashi et al.   ONCOGENE

AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation

(2013) R Jackstadt et al.   Cell Death & Disease

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

ATR–Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

(2011) Yoshihiko Fujinaka et al.   DNA REPAIR

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer

(2011) Chengfu Yuan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Participation of DNA repair in the response to 5-fluorouracil

(2008) M. D. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AP4 encodes a c-MYC-inducible repressor of p21

(2008) P. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

(2008) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA