Modulation of Pore Opening of Eukaryotic Sodium Channels by π-Helices in S6

Structural basis for modulation of human NaV1.3 by clinical drug and selective antagonist

(2022) Xiaojing Li et al.   Nature Communications

High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV

(2022) Gaoxingyu Huang et al.   Cell Reports

Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7

(2022) Gaoxingyu Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8

(2022) Xiaoshuang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An α–π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

(2022) Koushik Choudhury et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for NaV1.7 inhibition by pore blockers

(2022) Jiangtao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

(2021) Daohua Jiang et al.   Nature Communications

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine

(2021) Zhangqiang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies

(2021) Xiaojing Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Open-state structure and pore gating mechanism of the cardiac sodium channel

(2021) Daohua Jiang et al.   CELL

Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs

(2021) Denis B. Tikhonov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine

(2021) Koushik Choudhury et al.   BIOPHYSICAL JOURNAL

Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA

(2019) Xiaojing Pan et al.   SCIENCE

Structural basis of α-scorpion toxin action on Nav channels

(2019) Thomas Clairfeuille et al.   SCIENCE

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

The role of π-helices in TRP channel gating

(2019) Lejla Zubcevic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

(2018) Marina A. Kasimova et al.   Journal of Physical Chemistry Letters

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

Role of the Interaction Motif in Maintaining the Open Gate of an Open Sodium Channel

(2018) Song Ke et al.   BIOPHYSICAL JOURNAL

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel

(2013) M. B. Ulmschneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

(2013) Marcel P. Goldschen-Ohm et al.   Nature Communications