An α–π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV

(2022) Gaoxingyu Huang et al.   Cell Reports

A tamoxifen receptor within a voltage-gated sodium channel

(2021) Altin Sula et al.   MOLECULAR CELL

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

(2021) Daohua Jiang et al.   Nature Communications

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine

(2021) Zhangqiang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Open-state structure and pore gating mechanism of the cardiac sodium channel

(2021) Daohua Jiang et al.   CELL

Mapping Electromechanical Coupling Pathways in Voltage-Gated Ion Channels: Challenges and the Way Forward

(2021) John Cowgill et al.   JOURNAL OF MOLECULAR BIOLOGY

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine

(2021) Koushik Choudhury et al.   BIOPHYSICAL JOURNAL

Structural mechanisms of transient receptor potential ion channels

(2020) Erhu Cao   JOURNAL OF GENERAL PHYSIOLOGY

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT3 Receptor Channel

(2020) Gianni Klesse et al.   ACS Nano

Structure of the human sodium leak channel NALCN

(2020) Marc Kschonsak et al.   NATURE

Cannabidiol interactions with voltage-gated sodium channels

(2020) Lily Goodyer Sait et al.   eLife

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

(2019) Goragot Wisedchaisri et al.   CELL

CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores

(2019) Gianni Klesse et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of π-helices in TRP channel gating

(2019) Lejla Zubcevic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

(2019) João L. Carvalho-de-Souza et al.   Nature Communications

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

Optimized expression and purification of NavAb provide the structural insight into the voltage dependence

(2018) Katsumasa Irie et al.   FEBS LETTERS

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

(2018) Marina A. Kasimova et al.   Journal of Physical Chemistry Letters

Structural basis for gating pore current in periodic paralysis

(2018) Daohua Jiang et al.   NATURE

Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels

(2018) Amanda Buyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and gating mechanism of the transient receptor potential channel TRPV3

(2018) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

Role of the Interaction Motif in Maintaining the Open Gate of an Open Sodium Channel

(2018) Song Ke et al.   BIOPHYSICAL JOURNAL

CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans

(2018) Jumin Lee et al.   Journal of Chemical Theory and Computation

Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb

(2018) Tamer M. Gamal El-Din et al.   JOURNAL OF GENERAL PHYSIOLOGY

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine

(2018) Marina A. Kasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Fenestrations control resting-state block of a voltage-gated sodium channel

(2018) Tamer M. Gamal El-Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational ensemble of the human TRPV3 ion channel

(2018) Lejla Zubcevic et al.   Nature Communications

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Structures of closed and open states of a voltage-gated sodium channel

(2017) Michael J. Lenaeus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

The complete structure of an activated open sodium channel

(2017) Altin Sula et al.   Nature Communications

Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation

(2016) Cristina Arrigoni et al.   CELL

Molecular basis of ion permeability in a voltage‐gated sodium channel

(2016) Claire E Naylor et al.   EMBO JOURNAL

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

The hitchhiker’s guide to the voltage-gated sodium channel galaxy

(2015) Christopher A. Ahern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

(2015) Jian Payandeh et al.   JOURNAL OF MOLECULAR BIOLOGY

Accelerated weight histogram method for exploring free energy landscapes

(2014) V. Lindahl et al.   JOURNAL OF CHEMICAL PHYSICS

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

(2014) C. Bagneris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PLUMED 2: New feathers for an old bird

(2013) Gareth A. Tribello et al.   COMPUTER PHYSICS COMMUNICATIONS

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Two Alternative Conformations of a Voltage-Gated Sodium Channel

(2013) Ching-Ju Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

(2013) David Shaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of the C-terminal domain in the structure and function of tetrameric sodium channels

(2013) Claire Bagnéris et al.   Nature Communications

Local anesthetic inhibition of a bacterial sodium channel

(2012) Sora Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

(2012) Jian Payandeh et al.   NATURE

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

(2012) Emily C. McCusker et al.   Nature Communications

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

The Sodium Channel as a Target for Local Anesthetic Drugs

(2011) Harry A. Fozzard et al.   Frontiers in Pharmacology

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

PLUMED: A portable plugin for free-energy calculations with molecular dynamics

(2009) Massimiliano Bonomi et al.   COMPUTER PHYSICS COMMUNICATIONS

Simulation of Osmotic Pressure in Concentrated Aqueous Salt Solutions

(2009) Yun Luo et al.   Journal of Physical Chemistry Letters

Well-Tempered Metadynamics: A Smoothly Converging and Tunable Free-Energy Method

(2008) Alessandro Barducci et al.   PHYSICAL REVIEW LETTERS