An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine

A tamoxifen receptor within a voltage-gated sodium channel

(2021) Altin Sula et al.   MOLECULAR CELL

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

(2021) Daohua Jiang et al.   Nature Communications

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine

(2021) Zhangqiang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Induced Polarization in Molecular Dynamics Simulations of the 5-HT3 Receptor Channel

(2020) Gianni Klesse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT3 Receptor Channel

(2020) Gianni Klesse et al.   ACS Nano

Water in Nanopores and Biological Channels: A Molecular Simulation Perspective

(2020) Charlotte I. Lynch et al.   CHEMICAL REVIEWS

Cannabidiol interactions with voltage-gated sodium channels

(2020) Lily Goodyer Sait et al.   eLife

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

(2019) Goragot Wisedchaisri et al.   CELL

CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores

(2019) Gianni Klesse et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of π-helices in TRP channel gating

(2019) Lejla Zubcevic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

Water and hydrophobic gates in ion channels and nanopores

(2018) Shanlin Rao et al.   FARADAY DISCUSSIONS

Optimized expression and purification of NavAb provide the structural insight into the voltage dependence

(2018) Katsumasa Irie et al.   FEBS LETTERS

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

(2018) Marina A. Kasimova et al.   Journal of Physical Chemistry Letters

Structural basis for gating pore current in periodic paralysis

(2018) Daohua Jiang et al.   NATURE

Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels

(2018) Amanda Buyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Water and hydrophobic gates in ion channels and nanopores

(2018) Shanlin Rao et al.   FARADAY DISCUSSIONS

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

Role of the Interaction Motif in Maintaining the Open Gate of an Open Sodium Channel

(2018) Song Ke et al.   BIOPHYSICAL JOURNAL

CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans

(2018) Jumin Lee et al.   Journal of Chemical Theory and Computation

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine

(2018) Marina A. Kasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Fenestrations control resting-state block of a voltage-gated sodium channel

(2018) Tamer M. Gamal El-Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine

(2017) Andrias O. O’Reilly et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels

(2017) Altin Sula et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structures of closed and open states of a voltage-gated sodium channel

(2017) Michael J. Lenaeus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complete structure of an activated open sodium channel

(2017) Altin Sula et al.   Nature Communications

Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation

(2016) Cristina Arrigoni et al.   CELL

Molecular basis of ion permeability in a voltage‐gated sodium channel

(2016) Claire E Naylor et al.   EMBO JOURNAL

Functional Annotation of Ion Channel Structures by Molecular Simulation

(2016) Jemma L. Trick et al.   STRUCTURE

Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels

(2015) Michael F. Sheets et al.   BIOPHYSICAL JOURNAL

The hitchhiker’s guide to the voltage-gated sodium channel galaxy

(2015) Christopher A. Ahern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Comparative sequence analysis suggests a conserved gating mechanism for TRP channels

(2015) Eugene Palovcak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

(2015) Jian Payandeh et al.   JOURNAL OF MOLECULAR BIOLOGY

Accelerated weight histogram method for exploring free energy landscapes

(2014) V. Lindahl et al.   JOURNAL OF CHEMICAL PHYSICS

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

(2014) C. Bagneris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Two Alternative Conformations of a Voltage-Gated Sodium Channel

(2013) Ching-Ju Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

(2013) David Shaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel

(2013) M. B. Ulmschneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the C-terminal domain in the structure and function of tetrameric sodium channels

(2013) Claire Bagnéris et al.   Nature Communications

Drying Transition in the Hydrophobic Gate of the GLIC Channel Blocks Ion Conduction

(2012) Fangqiang Zhu et al.   BIOPHYSICAL JOURNAL

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

(2012) Jian Payandeh et al.   NATURE

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

(2012) Emily C. McCusker et al.   Nature Communications

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na+Channel

(2010) Touran Zarrabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Principles of conduction and hydrophobic gating in K+ channels

(2010) M. O. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Study of the Gating Motif and C-type Inactivation in Prokaryotic Voltage-gated Sodium Channels

(2009) Katsumasa Irie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY