Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

(2021) Daohua Jiang et al.   Nature Communications

Phenylalkylamines in calcium channels: computational analysis of experimental structures

(2020) Denis B. Tikhonov et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structure of human GABAB receptor in an inactive state

(2020) Jinseo Park et al.   NATURE

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds**

(2020) Shuai Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA

(2019) Xiaojing Pan et al.   SCIENCE

Structural basis of α-scorpion toxin action on Nav channels

(2019) Thomas Clairfeuille et al.   SCIENCE

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

(2019) Marcus Schewe et al.   SCIENCE

Structural basis for efonidipine block of a voltage-gated Ca2+ channel

(2019) Fuyan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel

(2019) Yanyu Zhao et al.   CELL

Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel

(2019) Lin Tang et al.   MOLECULAR PHARMACOLOGY

Cryo-EM structures of apo and antagonist-bound human Cav3.1

(2019) Yanyu Zhao et al.   NATURE

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Ca v Channels

(2018) Wilnelly Martinez-Ortiz et al.   Cell Reports

Mechanism of NMDA receptor channel block by MK-801 and memantine

(2018) Xianqiang Song et al.   NATURE

Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors

(2018) Edward C. Twomey et al.   NEURON

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

(2018) Denis B. Tikhonov et al.   Frontiers in Pharmacology

Fenestrations control resting-state block of a voltage-gated sodium channel

(2018) Tamer M. Gamal El-Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

(2017) Denis B. Tikhonov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of inter-residue contacts reveals folding stabilizers in P-loops of potassium, sodium, and TRPV channels

(2015) V. S. Korkosh et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site

(2014) Michael J. Lenaeus et al.   BIOCHEMISTRY

Ligand action on sodium, potassium, and calcium channels: role of permeant ions

(2013) Boris S. Zhorov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanism of Cd2+ Coordination during Slow Inactivation in Potassium Channels

(2012) H. Raghuraman et al.   STRUCTURE

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

(2012) Chunguang Kong et al.   eLife

Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function

(2010) Daniel P. Garden et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Improved prediction of protein side-chain conformations with SCWRL4

(2009) Georgii G. Krivov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS