Structural basis for NaV1.7 inhibition by pore blockers

Structural basis for modulation of human NaV1.3 by clinical drug and selective antagonist

(2022) Xiaojing Li et al.   Nature Communications

N-type fast inactivation of a eukaryotic voltage-gated sodium channel

(2022) Jiangtao Zhang et al.   Nature Communications

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

(2021) Daohua Jiang et al.   Nature Communications

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine

(2021) Zhangqiang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural pharmacology of voltage-gated sodium channels

(2021) Sigrid Noreng et al.   JOURNAL OF MOLECULAR BIOLOGY

Open-state structure and pore gating mechanism of the cardiac sodium channel

(2021) Daohua Jiang et al.   CELL

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA

(2019) Xiaojing Pan et al.   SCIENCE

Structural basis of α-scorpion toxin action on Nav channels

(2019) Thomas Clairfeuille et al.   SCIENCE

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics

(2019) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Nav1.7 withholds its pain potential

(2019) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

The Role of Voltage-Gated Sodium Channels in Pain Signaling

(2019) David L. Bennett et al.   PHYSIOLOGICAL REVIEWS

Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel

(2019) Yanyu Zhao et al.   CELL

Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels

(2019) William A. Catterall et al.   Annual Review of Pharmacology and Toxicology

Cryo-EM structures of apo and antagonist-bound human Cav3.1

(2019) Yanyu Zhao et al.   NATURE

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

Mapping protein interactions of sodium channel Na V 1.7 using epitope‐tagged gene‐targeted mice

(2018) Alexandros H Kanellopoulos et al.   EMBO JOURNAL

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial

(2017) Joanna M Zakrzewska et al.   LANCET NEUROLOGY

The chemical basis for electrical signaling

(2017) William A Catterall et al.   Nature Chemical Biology

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy

(2017) Iulia Blesneac et al.   PAIN

Near-Perfect Synaptic Integration by Na v 1.7 in Hypothalamic Neurons Regulates Body Weight

(2016) Tiago Branco et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia

(2016) Lishuang Cao et al.   Science Translational Medicine

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

(2016) Jennifer Deuis et al.   Toxins

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 α-subunits

(2012) Jérôme Clatot et al.   CARDIOVASCULAR RESEARCH

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

(2011) Sultan Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

(2011) Howard Bregman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sick Sinus Syndrome, Progressive Cardiac Conduction Disease, Atrial Flutter and Ventricular Tachycardia Caused by a Novel SCN5A Mutation

(2010) Anders G. Holst et al.   CARDIOLOGY

Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations

(2010) James J. Cox et al.   HUMAN MUTATION

Two novel SCN9A mutations causing insensitivity to pain

(2009) K. B. Nilsen et al.   PAIN