What is cancer metabolism?

Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

(2023) Timothy A. Yap et al.   NATURE MEDICINE

Spatially resolved isotope tracing reveals tissue metabolic activity

(2022) Lin Wang et al.   NATURE METHODS

Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

(2022) Rebecca L. Westbrook et al.   Cell Reports

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

(2022) Matteo Rossi et al.   NATURE

A non-canonical tricarboxylic acid cycle underlies cellular identity

(2022) Paige K. Arnold et al.   NATURE

Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells

(2022) Yahui Wang et al.   MOLECULAR CELL

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

(2022) Samuel A Kerk et al.   eLife

Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function

(2022) Giulia Notarangelo et al.   SCIENCE

In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

(2022) Panayotis Pachnis et al.   Science Advances

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

(2021) Nicholas J. Rossiter et al.   Cell Metabolism

Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells

(2021) Mark A. Keibler et al.   FEBS Journal

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Moonlighting functions of metabolic enzymes and metabolites in cancer

(2021) Chaoyun Pan et al.   MOLECULAR CELL

Dietary fructose improves intestinal cell survival and nutrient absorption

(2021) Samuel R. Taylor et al.   NATURE

Cycling cancer persister cells arise from lineages with distinct programs

(2021) Yaara Oren et al.   NATURE

The implications of IDH mutations for cancer development and therapy

(2021) Christopher J. Pirozzi et al.   Nature Reviews Clinical Oncology

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

(2021) Miyeko D. Mana et al.   Cell Reports

Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation

(2021) Sophie Trefely et al.   MOLECULAR CELL

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

(2021) Ying Wang et al.   NATURE

Targeting cancer metabolism in the era of precision oncology

(2021) Zachary E. Stine et al.   NATURE REVIEWS DRUG DISCOVERY

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

(2021) Jessica B. Spinelli et al.   SCIENCE

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

(2021) Sydney Campbell et al.   eLife

Hyaluronic acid fuels pancreatic cancer cell growth

(2021) Peter K Kim et al.   eLife

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

(2020) Eric C. Cheung et al.   CANCER CELL

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

(2020) John C. Charpentier et al.   Nature Communications

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Extracellular serine controls epidermal stem cell fate and tumour initiation

(2020) Sanjeethan C. Baksh et al.   NATURE CELL BIOLOGY

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases

(2020) Sanjeethan C. Baksh et al.   TRENDS IN CELL BIOLOGY

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

(2020) Xiphias Ge Zhu et al.   Cell Metabolism

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

(2020) Douglas E. Biancur et al.   Cell Metabolism

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

(2020) Alba Luengo et al.   MOLECULAR CELL

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

(2019) Grant M. Fischer et al.   Cancer Discovery

High-fructose corn syrup enhances intestinal tumor growth in mice

(2019) Marcus D. Goncalves et al.   SCIENCE

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

(2019) Mark R. Sullivan et al.   Cell Metabolism

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

(2019) Harihar Basnet et al.   eLife

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Metabolite Exchange between Mammalian Organs Quantified in Pigs

(2019) Cholsoon Jang et al.   Cell Metabolism

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

(2019) Pei-Hsuan Chen et al.   MOLECULAR CELL

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

Near-equilibrium glycolysis supports metabolic homeostasis and energy yield

(2019) Junyoung O. Park et al.   Nature Chemical Biology

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

(2019) Sophie Trefely et al.   Molecular Metabolism

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling

(2018) Joyce V. Lee et al.   GENES & DEVELOPMENT

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

(2018) Javier Garcia-Bermudez et al.   NATURE CELL BIOLOGY

Aspartate is an endogenous metabolic limitation for tumour growth

(2018) Lucas B. Sullivan et al.   NATURE CELL BIOLOGY

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

(2018) Parker L. Sulkowski et al.   NATURE GENETICS

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

(2018) Lukas Bunse et al.   NATURE MEDICINE

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

(2018) Matthias Muhar et al.   SCIENCE

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

(2018) Kevin D. Courtney et al.   Cell Metabolism

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

(2018) Andrew M. Intlekofer et al.   NATURE

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

(2017) Gary Kohanbash et al.   JOURNAL OF CLINICAL INVESTIGATION

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

(2017) Jiyeon Kim et al.   NATURE

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

The impact of cellular metabolism on chromatin dynamics and epigenetics

(2017) Michael A. Reid et al.   NATURE CELL BIOLOGY

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

Critical role for PI3-kinase in regulating the use of proteins as an amino acid source

(2017) Wilhelm Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

(2017) Parker L. Sulkowski et al.   Science Translational Medicine

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

(2016) Junyoung O Park et al.   Nature Chemical Biology

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

(2014) E.-H. Shim et al.   Cancer Discovery

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA