Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors

(2022) Filip Janku et al.   INVESTIGATIONAL NEW DRUGS

The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy

(2021) Stephanie M. Stanford et al.   JOURNAL OF CELLULAR PHYSIOLOGY

First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer

(2021) Filip Janku et al.   INVESTIGATIONAL NEW DRUGS

Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10

(2021) Mariaconcetta Durante et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

(2021) Lucille Stuani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

(2021) Injae Chung et al.   Science Advances

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition

(2021) Kaori Saito et al.   Blood Advances

An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway

(2021) Jixiang Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting cancer metabolism in the era of precision oncology

(2021) Zachary E. Stine et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer

(2020) Kazuyuki Kuramoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The fibroblast-derived protein PI16 controls neuropathic pain

(2020) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors.

(2020) Sun Young Rha et al.   JOURNAL OF CLINICAL ONCOLOGY

Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability

(2020) Geoffroy Laumet et al.   PAIN

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

(2020) Zoe A Stephenson et al.   eLife

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

(2020) Yibin Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neurological adverse events post allogeneic hematopoietic cell transplantation: major determinants of morbidity and mortality

(2019) Ioanna Sakellari et al.   JOURNAL OF NEUROLOGY

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

(2019) Irène Baccelli et al.   CANCER CELL

Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers

(2019) Jiacheng Ma et al.   PAIN

Systematic evaluation of RNA-Seq preparation protocol performance

(2019) Hsueh-Ping Chao et al.   BMC GENOMICS

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source

(2018) Jiacheng Ma et al.   CANCER

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

(2018) Yonathan Lissanu Deribe et al.   NATURE MEDICINE

Mitochondrial behavior during axon regeneration/degeneration in vivo

(2018) Sumiko Kiryu-Seo et al.   NEUROSCIENCE RESEARCH

Metabolic Profiles Associated With Metformin Efficacy in Cancer

(2018) Sylvia Andrzejewski et al.   Frontiers in Endocrinology

Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition

(2017) Andrew P. Trotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

(2017) Karen Krukowski et al.   PAIN

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

(2017) Magdalena A. Maj et al.   Frontiers in Molecular Neuroscience

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies

(2016) Mithilesh Kumar Jha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Seq2pathway: an R/Bioconductor package for pathway analysis of next-generation sequencing data: Fig. 1.

(2015) Bin Wang et al.   BIOINFORMATICS

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis

(2015) M. K. Jha et al.   JOURNAL OF NEUROSCIENCE

Neuromuscular complications of hematopoietic stem cell transplantation

(2015) Katherine M. Ruzhansky et al.   MUSCLE & NERVE

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ

(2015) Karen Krukowski et al.   PAIN

Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition

(2014) S. Piel et al.   Acta Physiologica

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Cardiac manifestations of primary mitochondrial disorders

(2014) Josef Finsterer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

(2014) Gary J. Bennett et al.   Nature Reviews Neurology

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Neuromuscular complications after hematopoietic stem cell transplantation

(2014) Susanne Koeppen et al.   SUPPORTIVE CARE IN CANCER

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy

(2012) H. Zheng et al.   EXPERIMENTAL NEUROLOGY

Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin

(2012) Wen Hua Xiao et al.   PAIN

Revised RECIST Guideline Version 1.1: What Oncologists Want to Know and What Radiologists Need to Know

(2010) Mizuki Nishino et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Complex I: Inhibitors, inhibition and neurodegeneration

(2010) A.H.V. Schapira   EXPERIMENTAL NEUROLOGY

Comparison of potential risks of lactic acidosis induction by biguanides in rats

(2010) Kiyoko Bando et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE

KEGG Atlas mapping for global analysis of metabolic pathways

(2008) S. Okuda et al.   NUCLEIC ACIDS RESEARCH

Rotenone-Induced Toxicity is Mediated by Rho-GTPases in Hippocampal Neurons

(2008) Monica Sanchez et al.   TOXICOLOGICAL SCIENCES

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY