Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

(2020) Kyuho Han et al.   NATURE

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer

(2019) Nithya Sivaram et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis

(2019) Yuya Kitajima et al.   Scientific Reports

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance

(2018) Douglas E. Biancur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics

(2018) Divya Murthy et al.   Frontiers in Physiology

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

(2018) Naiara Santana-Codina et al.   Nature Communications

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

(2016) Ryan J Park et al.   NATURE GENETICS

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3

(2015) Nadège Gaborit et al.   Human Vaccines & Immunotherapeutics

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

(2014) John G Doench et al.   NATURE BIOTECHNOLOGY

New Insights into Intracellular Locations and Functions of Heme Oxygenase-1

(2013) Louise L. Dunn et al.   ANTIOXIDANTS & REDOX SIGNALING

One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

(2012) Iqbal Hamza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation

(2012) Hirotsugu Kobuchi et al.   PLoS One

A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

(2012) Eric A. Collisson et al.   Cancer Discovery

Lapaquistat Acetate

(2011) Evan A. Stein et al.   CIRCULATION

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells

(2011) Tetsuya Ogino et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Ubiquitin-Specific Protease 8 Links the PTEN-Akt-AIP4 Pathway to the Control of FLIPSStability and TRAIL Sensitivity in Glioblastoma Multiforme

(2010) Amith Panner et al.   CANCER RESEARCH