In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

(2021) Nicole M. Anderson et al.   CANCER RESEARCH

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

Evidence that Oxidative Disbalance and Mitochondrial Dysfunction are Involved in the Pathophysiology of Fatty Acid Oxidation Disorders

(2020) Graziela Schmitt Ribas et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeted Determination of Tissue Energy Status by LC-MS/MS

(2019) Xiaorong Fu et al.   ANALYTICAL CHEMISTRY

Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex

(2019) Yudong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

(2019) Pei-Hsuan Chen et al.   MOLECULAR CELL

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors

(2018) Wenyun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

(2017) Monique Cunha de Padua et al.   Oncotarget

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines

(2017) Jo Lynne Harenza et al.   Scientific Data

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies

(2015) M. Wajner et al.   BIOSCIENCE REPORTS

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

(2012) Elsa Quintana et al.   Science Translational Medicine

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer