Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

(2019) Christopher J. Halbrook et al.   Cell Metabolism

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

(2019) Katherine Sellers et al.   BRITISH JOURNAL OF CANCER

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Determinants of nutrient limitation in cancer

(2019) Mark R. Sullivan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

(2019) Simona Dalin et al.   CANCER RESEARCH

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Identification of DHODH as a therapeutic target in small cell lung cancer

(2019) Leanne Li et al.   Science Translational Medicine

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

(2019) Claire Vennin et al.   Nature Communications

Metabolic landscape of the tumor microenvironment at single cell resolution

(2019) Zhengtao Xiao et al.   Nature Communications

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

The redox requirements of proliferating mammalian cells

(2018) Aaron M. Hosios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

(2018) Alicia M. Darnell et al.   MOLECULAR CELL

Aspartate is an endogenous metabolic limitation for tumour growth

(2018) Lucas B. Sullivan et al.   NATURE CELL BIOLOGY

Sorting cells alters their redox state and cellular metabolome

(2018) Elizabeth M. Llufrio et al.   Redox Biology

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

(2018) Alexander Muir et al.   Disease Models & Mechanisms

Altered exocrine function can drive adipose wasting in early pancreatic cancer

(2018) Laura V. Danai et al.   NATURE

Flow Cytometry Has a Significant Impact on the Cellular Metabolome

(2018) Aleksandra Binek et al.   JOURNAL OF PROTEOME RESEARCH

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

(2018) Naiara Santana-Codina et al.   Nature Communications

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Pancreatic stellate cell: Pandora's box for pancreatic disease biology

(2017) Ratnakar R Bynigeri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

(2017) Thuc M. Le et al.   Nature Communications

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

(2017) Alexander Muir et al.   eLife

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors

(2017) Annalisa Zecchin et al.   Frontiers in Immunology

The Role of 18F-FDG PET/CT and PET/MRI in Pancreatic Ductal Adenocarcinoma

(2017) Randy Yeh et al.   Abdominal Radiology

Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells

(2016) Irena Roci et al.   ANALYTICAL CHEMISTRY

SnapShot: Timescales in Cell Biology

(2016) Maya Shamir et al.   CELL

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Systems-level analysis of mechanisms regulating yeast metabolic flux

(2016) S. R. Hackett et al.   SCIENCE

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle

(2015) Tiago C. Alves et al.   Cell Metabolism

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Circulating protein synthesis rates reveal skeletal muscle proteome dynamics

(2015) Mahalakshmi Shankaran et al.   JOURNAL OF CLINICAL INVESTIGATION

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

13 C-metabolic flux analysis of co-cultures: A novel approach

(2015) Nikodimos A. Gebreselassie et al.   METABOLIC ENGINEERING

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

(2015) Courtney R Green et al.   Nature Chemical Biology

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

(2014) Tania Valencia et al.   CANCER CELL

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

A Peptide-Based Method for 13C Metabolic Flux Analysis in Microbial Communities

(2014) Amit Ghosh et al.   PLoS Computational Biology

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

(2013) N. Kumashiro et al.   DIABETES

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Parallel measurement of dynamic changes in translation rates in single cells

(2013) Kyuho Han et al.   NATURE METHODS

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Subpopulation-Specific Metabolic Pathway Usage in Mixed Cultures as Revealed by Reporter Protein-Based13C Analysis

(2011) Martin Rühl et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Pancreatic Cancer: The Role of Pancreatic Stellate Cells in Tumor Progression

(2011) Siri Dunér et al.   PANCREATOLOGY

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix

(2008) Jingjing Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells

(2007) Annette S. Vincent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY