Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

(2020) Tiffany Tsang et al.   NATURE CELL BIOLOGY

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

(2019) Jianping Guo et al.   NATURE CELL BIOLOGY

Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells

(2019) Silvia Baldari et al.   Cancers

Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma

(2018) Cristiana Porcu et al.   Oncotarget

Copper signaling in the brain and beyond

(2017) Cheri M. Ackerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3K/AKT Pathway as a Target for Cancer Treatment

(2016) Ingrid A. Mayer et al.   Annual Review of Medicine

miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients

(2016) András Lánczky et al.   BREAST CANCER RESEARCH AND TREATMENT

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity

(2016) Kristin M. Bompiani et al.   Metallomics

Copper regulates cyclic-AMP-dependent lipolysis

(2016) Lakshmi Krishnamoorthy et al.   Nature Chemical Biology

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

(2016) J. Guo et al.   SCIENCE

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

(2016) Jia Liu et al.   Cell Discovery

Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis

(2015) Susanne B. Breitkopf et al.   ANALYTICAL CHEMISTRY

NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling

(2014) Yan Zhang et al.   DEVELOPMENTAL BIOLOGY

Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer

(2014) Eric S. Kim et al.   LUNG CANCER

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

(2014) Pengda Liu et al.   NATURE

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

(2014) G. MacDonald et al.   Science Signaling

Structural and Functional Framework for the Autoinhibition of Nedd4-Family Ubiquitin Ligases

(2014) Sara Mari et al.   STRUCTURE

Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects

(2013) Martin Scheffner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

(2013) H. Ohrvik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling

(2012) Cheng-Yu Tsai et al.   BIOCHEMICAL PHARMACOLOGY

Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study

(2011) Yumiko Minagawa et al.   ANNALS OF NUCLEAR MEDICINE

A Chelator-Free Multifunctional [64Cu]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation Therapy

(2010) Min Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

(2005) Alessandra Gaeta et al.   BRITISH JOURNAL OF PHARMACOLOGY