Autophagy in cancer cell remodeling and quality control

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

(2022) Phyllis F. Cheung et al.   Nature Communications

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

(2021) Susanne Zellner et al.   MOLECULAR CELL

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

(2021) Suprit Gupta et al.   NATURE CELL BIOLOGY

Beyond Autophagy: The Expanding Roles of ATG8 Proteins

(2021) Jose L. Nieto-Torres et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Macroautophagy Machinery in MHC Restricted Antigen Presentation

(2021) Christian Münz   Frontiers in Immunology

Autophagosome biogenesis comes out of the black box

(2021) Chunmei Chang et al.   NATURE CELL BIOLOGY

Mechanisms of Selective Autophagy

(2021) Trond Lamark et al.   Annual Review of Cell and Developmental Biology

AMPK: restoring metabolic homeostasis over space and time

(2021) Elijah Trefts et al.   MOLECULAR CELL

Metabolomic profiling of single enlarged lysosomes

(2021) Hongying Zhu et al.   NATURE METHODS

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

(2021) Nicola Alesi et al.   Nature Communications

Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway

(2021) Katelyn Cassidy et al.   BIOCHEMISTRY

Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes

(2021) Suresh Kumar et al.   CELL

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

(2021) Vinay V Eapen et al.   eLife

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

(2020) Timothy Marsh et al.   DEVELOPMENTAL CELL

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Autophagosome biogenesis: From membrane growth to closure

(2020) Thomas J. Melia et al.   JOURNAL OF CELL BIOLOGY

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

(2020) Muhammad Zaeem Noman et al.   Science Advances

Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor

(2020) Amy H. Ponsford et al.   Autophagy

Emerging role of transcription factor EB in mitochondrial quality control

(2020) Shujun Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

The Lysosome at the Intersection of Cellular Growth and Destruction

(2020) Hijai R. Shin et al.   DEVELOPMENTAL CELL

Systematic quantitative analysis of ribosome inventory during nutrient stress

(2020) Heeseon An et al.   NATURE

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

(2020) Gennaro Napolitano et al.   NATURE

Iron and cancer: 2020 Vision

(2020) Suzy V. Torti et al.   CANCER RESEARCH

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

(2020) Oliver B. Davis et al.   DEVELOPMENTAL CELL

Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion

(2019) Irmina A. Elliott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

(2019) Takuo Osawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

(2019) Vrushank Bhatt et al.   GENES & DEVELOPMENT

Host Control of Tumor Feeding: Autophagy Holds the Key

(2019) Anthony Venida et al.   Cell Metabolism

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features

(2019) Farhadul Islam et al.   HUMAN PATHOLOGY

Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

(2019) Carolin Schmidtke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer

(2019) Timothy J Humpton et al.   Cancer Discovery

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

(2019) Gabriela Andrejeva et al.   Autophagy

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

ER-phagy and human diseases

(2019) Christian A. Hübner et al.   CELL DEATH AND DIFFERENTIATION

Rapid affinity purification of intracellular organelles using a twin strep tag

(2019) Jian Xiong et al.   JOURNAL OF CELL SCIENCE

The ATG conjugation systems in autophagy

(2019) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

(2018) Samrat T. Kundu et al.   Nature Communications

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

Metastatic cells are preferentially vulnerable to lysosomal inhibition

(2018) Michael J. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

(2018) Lillian J. Eichner et al.   Cell Metabolism

FAM 134B induces tumorigenesis and epithelial‐to‐mesenchymal transition via Akt signaling in hepatocellular carcinoma

(2018) Zhao‐qi Zhang et al.   Molecular Oncology

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

(2018) Eutteum Jeong et al.   eLife

Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells

(2018) Seth D. Merkley et al.   Frontiers in Immunology

Macropinocytosis and autophagy crosstalk in nutrient scavenging

(2018) Oliver Florey et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II

(2017) Sandra Markmann et al.   MOLECULAR & CELLULAR PROTEOMICS

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

(2017) François Le Guerroué et al.   MOLECULAR CELL

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

(2017) Heeseon An et al.   NATURE CELL BIOLOGY

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

(2017) Takouhie Mgrditchian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

(2017) Chiara Di Malta et al.   SCIENCE

Expanding perspectives on the significance of mitophagy in cancer

(2017) Lauren E. Drake et al.   SEMINARS IN CANCER BIOLOGY

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Suppression of autophagy impedes glioblastoma development and induces senescence

(2016) Noor Gammoh et al.   Autophagy

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

TFEB and TFE3 are novel components of the integrated stress response

(2016) J. A. Martina et al.   EMBO JOURNAL

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

NBR1 enables autophagy-dependent focal adhesion turnover

(2016) Candia M. Kenific et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

(2016) Joseph D. Mancias et al.   JOURNAL OF MOLECULAR BIOLOGY

An improved smaller biotin ligase for BioID proximity labeling

(2016) Dae In Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy

(2016) Tian Zhang et al.   Cell Reports

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

(2016) S. Yang et al.   Cancer Immunology Research

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

(2015) Chandra B Lebovitz et al.   Autophagy

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

(2015) Diego Ploper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism

(2015) Shuyan Xiao et al.   STRUCTURE

Cellular and metabolic functions for autophagy in cancer cells

(2015) Candia M. Kenific et al.   TRENDS IN CELL BIOLOGY

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Characterization of early autophagy signaling by quantitative phosphoproteomics

(2014) Kristoffer TG Rigbolt et al.   Autophagy

Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

(2014) Robin Mathew et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Dissecting the role of the Atg12–Atg5-Atg16 complex during autophagosome formation

(2013) Marta Walczak et al.   Autophagy

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

An Extended Proteome Map of the Lysosomal Membrane Reveals Novel Potential Transporters

(2013) Agnès Chapel et al.   MOLECULAR & CELLULAR PROTEOMICS

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells

(2012) Emma Sandilands et al.   EMBO REPORTS

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Classification of Subcellular Location by Comparative Proteomic Analysis of Native and Density-shifted Lysosomes

(2011) Maria Cecilia Della Valle et al.   MOLECULAR & CELLULAR PROTEOMICS

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

ErbB2-associated changes in the lysosomal proteome

(2011) Jesper Nylandsted et al.   PROTEOMICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover

(2009) Sarah Waters et al.   FEBS LETTERS

Biochemical Isolation and Characterization of the Tubulovesicular LC3-positive Autophagosomal Compartment

(2009) Wentao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Proteomics of the lysosome

(2008) Torben Lübke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

The Mannose 6-Phosphate Glycoprotein Proteome

(2008) David E. Sleat et al.   JOURNAL OF PROTEOME RESEARCH

Ordered Organelle Degradation during Starvation-induced Autophagy

(2008) Anders Riis Kristensen et al.   MOLECULAR & CELLULAR PROTEOMICS