Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

A preliminary clinical trial to evaluate 64Cu-NOTA-Trastuzumab as a positron emission tomography imaging agent in patients with breast cancer

(2021) Inki Lee et al.   EJNMMI Research

Cyclodextrin Diethyldithiocarbamate Copper II Inclusion Complexes: A Promising Chemotherapeutic Delivery System against Chemoresistant Triple Negative Breast Cancer Cell Lines

(2021) Ammar Said Suliman et al.   Pharmaceutics

A Three-in-one ZIFs-Derived CuCo(O)/GOx@PCNs Hybrid Cascade Nanozyme for Immunotherapy/Enhanced Starvation/Photothermal Therapy

(2021) Qi Wang et al.   ACS Applied Materials & Interfaces

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

(2021) Jianping Liu et al.   ACS Applied Materials & Interfaces

NIR-Driven Intracellular Photocatalytic O2 Evolution on Z-Scheme Ni3S2/Cu1.8S@HA for Hypoxic Tumor Therapy

(2021) Dongmiao Sang et al.   ACS Applied Materials & Interfaces

Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management

(2021) Jacinta O. Pinho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Laser-induced thermal response and controlled release of copper oxide nanoparticles from multifunctional polymeric nanocarriers

(2021) Inbal Maor et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy

(2021) Nada S. Aboelella et al.   Cancers

A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

(2021) Shulong Wang et al.   Science Advances

Autophagy-Dependent Apoptosis Induced by Apoferritin–Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells

(2021) Kai Xiong et al.   ACS Applied Materials & Interfaces

Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites

(2021) Parbeen Singh et al.   ACS Applied Materials & Interfaces

Massive Intracellular Remodeling of CuS Nanomaterials Produces Nontoxic Bioengineered Structures with Preserved Photothermal Potential

(2021) Alberto Curcio et al.   ACS Nano

Synthesis of one-for-all type Cu5FeS4 nanocrystals with improved near infrared photothermal and Fenton effects for simultaneous imaging and therapy of tumor

(2021) Zhaojie Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Latest advances in imaging oxidative stress in cancer

(2021) Hannah E Greenwood et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

(2021) Friederike Hartwig et al.   Pharmaceutics

Self-assembled semiconducting polymer based hybrid nanoagents for synergistic tumor treatment

(2021) Anivind Kaur Bindra et al.   BIOMATERIALS

ROS generation/scavenging modulation of carbon dots as phototherapeutic candidates and peroxidase mimetics to integrate with polydopamine nanoparticles/GOx towards cooperative cancer therapy

(2021) Girum Getachew et al.   COMPOSITES PART B-ENGINEERING

The effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction

(2021) Klaudia Jomova et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Copper in tumors and the use of copper-based compounds in cancer treatment

(2021) Daniela Almeida da Silva et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Trace elements under the spotlight: A powerful nutritional tool in cancer

(2021) Elisabet Rodríguez-Tomàs et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy

(2020) Changchang Zhang et al.   ACS Applied Materials & Interfaces

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Current Biomedical Use of Copper Chelation Therapy

(2020) Silvia Baldari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy

(2020) Anne McMahon et al.   JOURNAL OF CONTROLLED RELEASE

Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

(2020) Zhao Wang et al.   ACS Applied Materials & Interfaces

Clearable Black Phosphorus Nanoconjugate for Targeted Cancer Phototheranostics

(2020) Deblin Jana et al.   ACS Applied Materials & Interfaces

Copper‐Enriched Prussian Blue Nanomedicine for In Situ Disulfiram Toxification and Photothermal Antitumor Amplification

(2020) Wencheng Wu et al.   ADVANCED MATERIALS

Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic

(2020) Tao Sun et al.   JOURNAL OF CONTROLLED RELEASE

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

(2020) Tiffany Tsang et al.   NATURE CELL BIOLOGY

Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy

(2020) Haifeng Yuan et al.   Science China-Chemistry

Immunogenic Cell Death of Breast Cancer Stem Cells by an Endoplasmic Reticulum‐Targeting Copper(II) Complex

(2020) Pooja Kaur et al.   CHEMBIOCHEM

Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H2O2

(2020) Rui Cao et al.   CHINESE CHEMICAL LETTERS

Transition metal complexes as proteasome inhibitors for cancer treatment

(2020) Shagufta et al.   INORGANICA CHIMICA ACTA

Copper Coordination Compounds as Biologically Active Agents

(2020) Olga Krasnovskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

(2020) Katarzyna Gałczyńska et al.   MOLECULES

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Recent Advances in Combination of Copper Chalcogenides-based Photothermal and Reactive Oxygen Species-related Therapies

(2020) Yi Zhao et al.   ACS Biomaterials-Science & Engineering

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu 2+ Nanoassemblies

(2020) Shan Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper sulphide based heterogeneous nanoplatforms for multimodal therapy and imaging of cancer: Recent advances and toxicological perspectives

(2020) Ajinkya N. Nikam et al.   COORDINATION CHEMISTRY REVIEWS

Induction of Redox-Mediated Cell Death in ER-Positive and ER-Negative Breast Cancer Cells by a Copper(II)-Phenolate Complex: An In Vitro and In Silico Study

(2020) Vaiyapuri Subbarayan Periasamy et al.   MOLECULES

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

(2020) Liyang Cui et al.   NATURE BIOTECHNOLOGY

Getting out what you put in: Copper in mitochondria and its impacts on human disease

(2020) Paul A. Cobine et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy

(2020) Pierre Lelièvre et al.   Cancers

Diverse biological roles of the tetrathiomolybdate anion

(2020) Biplab K. Maiti et al.   COORDINATION CHEMISTRY REVIEWS

Towards applications of bioentities@MOFs in biomedicine

(2020) Miriam de J. Velásquez-Hernández et al.   COORDINATION CHEMISTRY REVIEWS

Copper-containing bioactive glasses and glass-ceramics: From tissue regeneration to cancer therapeutic strategies

(2020) Saeid Kargozar et al.   Materials Science & Engineering C-Materials for Biological Applications

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

(2020) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Poly(amidoamine) Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis

(2019) Yu Fan et al.   NANO LETTERS

Inhibition of Copper Transport Induces Apoptosis in Triple Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis

(2019) Olga Karginova et al.   MOLECULAR CANCER THERAPEUTICS

Albumin-functionalized cufes2/photosensitizer nanohybrid for single-laser-induced folate receptor-targeted photothermal and photodynamic therapy

(2019) Wubshet Mekonnen Girma et al.   Materials Science & Engineering C-Materials for Biological Applications

Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer

(2019) Ping Zhou et al.   BIOMATERIALS

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

(2019) Conghui Liu et al.   ACS Nano

Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells

(2019) Silvia Baldari et al.   Cancers

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

(2019) Li-Sen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors

(2019) Samana Shrestha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper homeostasis as target of both consolidated and innovative strategies of anti-tumor therapy

(2019) Anastasia De Luca et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Boosting H 2 O 2 ‐Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near‐Infrared Light Irradiation

(2019) Tingting Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Copper(I) Phosphide Nanocrystals for In Situ Self‐Generation Magnetic Resonance Imaging‐Guided Photothermal‐Enhanced Chemodynamic Synergetic Therapy Resisting Deep‐Seated Tumor

(2019) Yang Liu et al.   ADVANCED FUNCTIONAL MATERIALS

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu 2 MoS 4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

(2019) Mengyu Chang et al.   ADVANCED MATERIALS

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

(2019) Jiangjuan Shao et al.   Cell Communication and Signaling

Responsively Aggregatable Sub-6 nm Nanochelators Induce Simultaneous Antiangiogenesis and Vascular Obstruction for Enhanced Tumor Vasculature Targeted Therapy

(2019) Yannan Yang et al.   NANO LETTERS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent

(2019) Dorothea M. Heuberger et al.   Scientific Reports

Defective Porous Carbon Polyhedra Decorated with Copper Nanoparticles for Enhanced NIR‐Driven Photothermal Cancer Therapy

(2019) Yangziwan Weng et al.   Small

Copper-induced apoptosis and autophagy through oxidative stress-mediated mitochondrial dysfunction in male germ cells

(2019) Zhenlong Kang et al.   TOXICOLOGY IN VITRO

Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation

(2019) Zheng-Hong Liu et al.   OncoTargets and Therapy

A hollow Cu9S8 theranostic nanoplatform based on a combination of increased active sites and photothermal performance in enhanced chemodynamic therapy

(2019) Yurui Wang et al.   CHEMICAL ENGINEERING JOURNAL

All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication

(2018) Yang Liu et al.   ACS Nano

Erythrocyte–Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma

(2018) Dongdong Wang et al.   ACS Nano

Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles

(2018) Na Li et al.   ACS Nano

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

(2018) Teresa Simon-Yarza et al.   ADVANCED MATERIALS

Versatile hyaluronic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Multiple tumor targeting, highly efficient synergistic chemotherapy, and real-time self-monitoring

(2018) Shihong Shen et al.   BIOMATERIALS

Disulfiram/copper causes ROS levels alteration, cell cycle inhibition, and apoptosis in acute myeloid leukaemia cell lines with modulation in the expression of related genes

(2018) Saeed Hassani et al.   BIOMEDICINE & PHARMACOTHERAPY

A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer

(2018) Cynthia Al Hageh et al.   DALTON TRANSACTIONS

Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone

(2018) Xia-Zhen Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

AN OVERVIEW ON PET RADIOCHEMISTRY: PART 2 - RADIOMETALS

(2018) Marie Brandt et al.   JOURNAL OF NUCLEAR MEDICINE

Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold–Copper Sulfide Yolk–Shell Nanoparticles for Chemophototherapy of Cancer

(2018) Yun Chang et al.   NANO LETTERS

Piperidylthiosemicarbazones Cu(II) complexes with a high anticancer activity by catalyzing hydrogen peroxide to degrade DNA and promote apoptosis

(2018) Jinxu Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Wilson disease

(2018) Anna Członkowska et al.   Nature Reviews Disease Primers

Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers

(2018) Wu Chen et al.   ACS Applied Materials & Interfaces

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin

(2018) Hye-Yeong Kim et al.   ACS Nano

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion

(2018) Lu Zhang et al.   NANO LETTERS

D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H 2 O 2 -mediated oxidative stress

(2017) Sebastian J. Sciegienka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents

(2017) Valentina Oliveri et al.   Metallomics

Copper Sulfide Perfluorocarbon Nanodroplets as Clinically Relevant Photoacoustic/Ultrasound Imaging Agents

(2017) Daniela Y. Santiesteban et al.   NANO LETTERS

An intelligent NIR-responsive chelate copper-based anticancer nanoplatform for synergistic tumor targeted chemo-phototherapy

(2017) Qianhua Feng et al.   Nanoscale

Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy

(2017) Carlos Angelé-Martínez et al.   Nanotoxicology

Chlorin e6 conjugated copper sulfide nanoparticles for photodynamic combined photothermal therapy

(2017) Subramaniyan Bharathiraja et al.   Photodiagnosis and Photodynamic Therapy

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells

(2017) Eugene M. H. Yee et al.   Scientific Reports

Nanoarchitectured Design of Porous Materials and Nanocomposites from Metal-Organic Frameworks

(2016) Yusuf Valentino Kaneti et al.   ADVANCED MATERIALS

Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes

(2016) Janine N. Boodram et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Based Nanomaterials for Cancer Imaging and Therapy

(2016) Min Zhou et al.   BIOCONJUGATE CHEMISTRY

PD-L1 Detection in Tumors Using [64Cu]Atezolizumab with PET

(2016) Wojciech G. Lesniak et al.   BIOCONJUGATE CHEMISTRY

Discovery of a potent and highly specific β 2 proteasome inhibitor from a library of copper complexes

(2016) Tongliang Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Copper(II)-Catalyzed Oxidation of Glutathione

(2016) Kamonwad Ngamchuea et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light

(2016) Luke K. McKenzie et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

(2016) Ran Mo et al.   Materials Today

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics

(2016) Kyung Chan Park et al.   Metallomics

Novel copper complexes as potential proteasome inhibitors for cancer treatment

(2016) Zhen Zhang et al.   Molecular Medicine Reports

64Cu2+ Ions as PET Probe: An Emerging Paradigm in Molecular Imaging of Cancer

(2016) Rubel Chakravarty et al.   MOLECULAR PHARMACEUTICS

Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma

(2016) Jason Wachsmann   WORLD JOURNAL OF GASTROENTEROLOGY

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

(2016) Anna Maria Santoro et al.   Scientific Reports

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction

(2015) Creina Slator et al.   ACS Chemical Biology

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates

(2015) Lei Zhang et al.   Nanoscale

Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells

(2015) Kyu Kwang Kim et al.   Scientific Reports

Functional Nanomaterials for Phototherapies of Cancer

(2014) Liang Cheng et al.   CHEMICAL REVIEWS

Review of iron-free Fenton-like systems for activating H2O2 in advanced oxidation processes

(2014) Alok D. Bokare et al.   JOURNAL OF HAZARDOUS MATERIALS

Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

(2013) Michael A. Cater et al.   ACS Chemical Biology

Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

(2013) Kai Dong et al.   ADVANCED MATERIALS

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Synthesis and Biomedical Applications of Copper Sulfide Nanoparticles: From Sensors to Theranostics

(2013) Shreya Goel et al.   Small

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

(2012) Masazumi Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

(2012) L. V. Wang et al.   SCIENCE

Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer

(2012) Jiyun Shi et al.   Theranostics

A Chelator-Free Multifunctional [64Cu]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation Therapy

(2010) Min Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper Compounds in Anticancer Strategies

(2009) Saverio Tardito et al.   CURRENT MEDICINAL CHEMISTRY