Review
Chemistry, Inorganic & Nuclear
Ying Yang, Man Li, Gang Chen, Suyi Liu, Houqi Guo, Xiongwei Dong, Kai Wang, Hongen Geng, Jun Jiang, Xiang Li
Summary: Copper plays a crucial role in various processes of cell survival and cancer treatment. Both excess and depletion of copper are associated with diseases, making them potential therapeutic targets for cancer. However, there is a lack of systematic reviews on copper-based cancer therapy from both biological and chemical perspectives. This review provides a comprehensive overview of copper biology and the use of copper targeted therapy in cancer treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Engineering, Environmental
Xiao Li, Ying Cui, Tianhua Zhou, Jianguang Li, Pei Lu, Lihui Yuwen, Lianhui Wang, Lixing Weng
Summary: Copper ion is essential in physiological processes but abnormal levels can cause diseases. Traditional detection methods are invasive and cannot reflect real-time copper levels. Nanotechnology shows great potential in diagnosing and treating copper-related diseases. This review summarizes recent advances in copper ion-related nanomedicine, analyzes critical concerns, and provides future perspectives.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Oncology
Xiaolong Tang, Zaihua Yan, Yandong Miao, Wuhua Ha, Zheng Li, Lixia Yang, Denghai Mi
Summary: Copper, as an essential nutrient, can have both beneficial and toxic effects on cells. Utilizing copper-dependent diseases or copper toxicity may provide new strategies for specific disease treatments. Especially in cancer cells, high copper concentration makes it a critical nutrient for tumor growth, and intervening in cancer cell copper metabolism could be a potential tumor treatment strategy. This review discusses copper metabolism in the body, its role in tumor cell growth and programmed cell death, and the potential of copper-related drugs in cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Fu Cheng, Geng Peng, Yan Lu, Kang Wang, Qinuo Ju, Yongle Ju, Manzhao Ouyang
Summary: Copper ions are essential for the development and function of the immune system. Both copper deficiency and elevated copper levels have been linked to various diseases, including immune system disorders and tumor development. Recent studies have also revealed the role of copper ions in regulating tumor immunity through gene expression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiazhu Zheng, Haoying Ge, Mengya Guo, Tingyu Zhang, Qiao Hu, Qichao Yao, Saran Long, Wen Sun, Jiangli Fan, Jianjun Du, Xiaojun Peng
Summary: This study develops a novel method to induce copper-induced cell death (cuproptosis) in tumor cells by utilizing copper ionophores and the tumor microenvironment. The CJS-Cu nanoparticles selectively induce cuproptosis and effectively suppress tumor growth and metastasis.
Article
Oncology
Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin, Lifeng Feng
Summary: This study found that ferroptosis inducers sorafenib and erastin could enhance cuproptosis in primary liver cancer cells by increasing copper dependent lipoylated protein aggregation. Mechanically, sorafenib and erastin upregulated protein lipoylation via suppressing mitochondrial matrix-related proteases mediated ferredoxin 1 (FDX1) protein degradation, and reduced intracellular copper chelator glutathione (GSH) synthesis through inhibiting cystine importing.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Pratibha Pandey, Fahad Khan, Huda A. Qari, Tarun Kumar Upadhyay, Abdulhameed F. Alkhateeb, Mohammad Oves
Summary: This review summarizes the recent advancements in cancer therapies involving ionophores and highlights the potential of ionophores in modulating cell signaling pathways and enhancing antitumor immunity. The study provides a robust future perspective for the development of cost-effective anticancer drugs.
Review
Biochemistry & Molecular Biology
Maria Babak, Dohyun Ahn
Summary: Copper plays a crucial role in cellular growth and development and its imbalance can lead to toxicity. This review explores the mechanisms of intracellular copper balance interference in tumor development and progression, and discusses the potential of using copper-depleting and copper-overloading conditions for improved patient outcomes. Additionally, the advantages of pre-formed copper complexes in comparison to in situ formed complexes are highlighted.
Review
Biochemistry & Molecular Biology
Valentina Oliveri
Summary: Conventional cancer therapies face challenges due to off-target effects, leading to the need for new therapeutic agents with increased selectivity, reduced side effects, and the ability to overcome cancer cell resistance targeting cancer stem cells. Some copper ionophores show promise in inducing cuproptosis in cancer cells with greater selectivity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Pharmacology & Pharmacy
DaeYong Lee, JongHoon Ha, Minjeong Kang, Zhaogang Yang, Wen Jiang, Betty Y. S. Kim
Summary: Perturbing ion homeostasis has emerged as a novel therapeutic strategy for cancer treatment, which can activate cell death signaling pathways or enhance antitumor immunity. Though the mechanisms of ion homeostasis-disturbing agents are not yet fully understood, recent studies have revealed new mechanisms and their potential clinical applications as anticancer agents.
ADVANCED THERAPEUTICS
(2022)
Review
Oncology
Zhengting Jiang, Gengyu Sha, Wenjie Zhang, Zhilin Zhang, Tian Liu, Daorong Wang, Dong Tang
Summary: Colorectal cancer (CRC) is a common and deadly disease that is often diagnosed late and poorly treated with conventional methods. Copper, a mineral nutrient, has dual effects on cancer production and treatment. It can be used to develop anti-cancer drugs due to its redox properties, but it can also lead to oxidative stress and potentially cancer. The status of copper is closely related to the proliferation and metastasis of colorectal tumors. Understanding the mechanisms of altered copper status is crucial for developing effective treatments for CRC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Xidi Wang, Miao Zhou, Yu Liu, Zizhen Si
Summary: Recent studies have found a strong link between copper and cancer biology, as it is necessary for cancer growth and metastasis. Copper not only serves as a catalytic cofactor, but also regulates signaling transduction and gene expression, vital for tumorigenesis and cancer progression. The redox properties of copper can have both beneficial and detrimental effects on cancer cells, suggesting that copper depletion and supplementation may offer new approaches for anticancer therapies.
Review
Chemistry, Multidisciplinary
Wuyin Wang, Wentao Mo, Zishan Hang, Yueying Huang, Hong Yi, Zhijun Sun, Aiwen Lei
Summary: Transition metal element, copper, plays diverse and pivotal roles in oncology. It acts as constituents of metalloenzymes involved in cellular metabolism, function as signaling molecules to regulate the proliferation and metastasis of tumors, and are integral components of metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate the occurrence of programmed cell death (PCD), known as cuprotosis, in cancer cells.
Review
Biochemistry & Molecular Biology
Alyssa L. Carlson, Jaime Carrazco-Carrillo, Aaron Loder, Lobna Elkhadragy, Kyle M. Schachtschneider, Teresita Padilla-Benavides
Summary: Copper plays a significant role in the development of cancer, particularly in cell signaling, cell cycle progression, epithelial-mesenchymal transition, tumor growth, and metastasis. Traditional cancer cell lines and mouse models have limitations when extrapolating to humans, but larger animal models like pigs, which share more similarities in genetics, anatomical structures, organ sizes, and disease manifestations, are emerging as ideal tools for cancer research and drug development. The Oncopig Cancer Model, which develops specific tumors, provides a better understanding of the mechanisms and causal relationships between copper and molecular targets involved in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marianna Tosato, Marco Verona, Chiara Favaretto, Marco Pometti, Giordano Zanoni, Fabrizio Scopelliti, Francesco Paolo Cammarata, Luca Morselli, Zeynep Talip, Nicholas P. van der Meulen, Valerio Di Marco, Mattia Asti
Summary: This study evaluated the labeling performance and stability of a series of S-rich polyazamacrocyclic chelators with [Cu-64]Cu2+. Among the chelators considered, DO2A2S showed the best results. DO2A2S was labeled at high molar activities in mild reaction conditions, and its [Cu-64]Cu2+ complex exhibited excellent integrity in human serum.