Do different exosome biogenesis pathways and selective cargo enrichment contribute to exosomal heterogeneity?

GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

(2023) Yu Jin Lee et al.   DEVELOPMENTAL CELL

Reversible zwitterionic coordination enables rapid, high-yield, and high-purity isolation of extracellular vesicles from biofluids

(2023) Qiang Li et al.   Science Advances

Cascaded microfluidic circuits for pulsatile filtration of extracellular vesicles from whole blood for early cancer diagnosis

(2023) Zhenglin Li et al.   Science Advances

Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness

(2022) Elena Arance et al.   Cancers

Raman spectroscopy combined with comprehensive gas chromatography for label-free characterization of plasma-derived extracellular vesicle subpopulations

(2022) Thanaporn Liangsupree et al.   ANALYTICAL BIOCHEMISTRY

VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

(2022) Bahnisikha Barman et al.   DEVELOPMENTAL CELL

Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart Diseases

(2022) Jin-Taek Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LAMP2A regulates the loading of proteins into exosomes

(2022) João Vasco Ferreira et al.   Science Advances

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

(2022) Simone M. Crivelli et al.   Journal of Extracellular Vesicles

Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples

(2022) Nasibeh Karimi et al.   Journal of Extracellular Vesicles

Single Extracellular Vesicle Analysis Using Flow Cytometry for Neurological Disorder Biomarkers

(2022) Houda Yasmine Ali Moussa et al.   Frontiers in Integrative Neuroscience

A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER)

(2022) Jinxin Zhang et al.   Science Advances

The characterization of exosomes from fibrosarcoma cell and the useful usage of Dynamic Light Scattering (DLS) for their evaluation

(2021) Tae Seong Lyu et al.   PLoS One

CD9 Upregulation-Decreased CCL21 Secretion in Mesenchymal Stem Cells Reduces Cancer Cell Migration

(2021) Chia-Chu Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD63+ extracellular vesicles from retinal pigment epithelial cells participate in crosstalk with macrophages in the innate inflammatory axis

(2021) Yohei Otsuki et al.   EXPERIMENTAL EYE RESEARCH

Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells

(2021) Olga E. Andreeva et al.   MOLECULES

Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying α-Synuclein–Containing Extracellular Vesicles

(2021) Zhen Hong et al.   NEUROLOGY

Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology

(2021) Karmele Valencia et al.   Cancers

Extracellular Vesicle Surface Signatures in IPF Patients: A Multiplex Bead-Based Flow Cytometry Approach

(2021) Miriana d’Alessandro et al.   Cells

Exosomal Transfer of miR-185 Is Controlled by hnRNPA2B1 and Impairs Re-endothelialization After Vascular Injury

(2021) Yi Si et al.   Frontiers in Cell and Developmental Biology

Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma

(2021) Jinchao Si et al.   CANCER SCIENCE

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

(2021) Clair Crewe et al.   Cell Metabolism

Deterministic Sorting of Submicrometer Particles and Extracellular Vesicles Using a Combined Electric and Acoustic Field

(2021) Mahnoush Tayebi et al.   NANO LETTERS

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma

(2021) Moh’d Khushman et al.   Oncotarget

The Fatty Acid and Protein Profiles of Circulating CD81-Positive Small Extracellular Vesicles Are Associated with Disease Stage in Melanoma Patients

(2021) Giovanni Paolino et al.   Cancers

Single-Cell Cloning of Breast Cancer Cells Secreting Specific Subsets of Extracellular Vesicles

(2021) Mohsen Fathi et al.   Cancers

Androgens alter the heterogeneity of small extracellular vesicles and the small RNA cargo in prostate cancer

(2021) Elena S. Martens‐Uzunova et al.   Journal of Extracellular Vesicles

Heterogeneous Nuclear Ribonucleoprotein A1 Loads Batched Tumor-Promoting MicroRNAs Into Small Extracellular Vesicles With the Assist of Caveolin-1 in A549 Cells

(2021) Yangyang Li et al.   Frontiers in Cell and Developmental Biology

New Multiscale Characterization Methodology for Effective Determination of Isolation–Structure–Function Relationship of Extracellular Vesicles

(2021) Thanh Huyen Phan et al.   Frontiers in Bioengineering and Biotechnology

Movement of Mitochondria with Mutant DNA through Extracellular Vesicles Helps Cancer Cells Acquire Chemoresistance

(2021) Etna Abad et al.   ChemMedChem

Reassessment of the Proteomic Composition and Function of Extracellular Vesicles in the Seminal Plasma

(2021) Hanshu Wang et al.   ENDOCRINOLOGY

Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells

(2021) Anisha D'Souza et al.   JOURNAL OF CONTROLLED RELEASE

Isolation of extra-cellular vesicles in the context of pancreatic adenocarcinomas: Addition of one stringent filtration step improves recovery of specific microRNAs

(2021) Yi-Fan Xu et al.   PLoS One

ExoPRIME: Solid-phase immunoisolation and OMICS analysis of surface-marker-specific exosomal subpopulations

(2021) Chukwumaobim D. Nwokwu et al.   TALANTA

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

(2021) Xiao-Man Liu et al.   eLife

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures

(2021) Whitaker Cohn et al.   Frontiers in Pharmacology

Clinical Significance of Plasma CD9-Positive Exosomes in HIV Seronegative and Seropositive Lung Cancer Patients

(2021) Foteinos-Ioannis Dimitrakopoulos et al.   Cancers

Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

(2021) Pamela J. Yao et al.   Biomedicines

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

(2020) Jorge Larios et al.   JOURNAL OF CELL BIOLOGY

Direct comparison of optical and electron microscopy methods for structural characterization of extracellular vesicles

(2020) Jade M. Noble et al.   JOURNAL OF STRUCTURAL BIOLOGY

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

The EV-TRACK summary add-on: integration of experimental information in databases to ensure comprehensive interpretation of biological knowledge on extracellular vesicles

(2020) Quentin Roux et al.   Journal of Extracellular Vesicles

DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses

(2020) Kazuhiro Hitomi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines

(2020) Atsushi Matsuda et al.   JOURNAL OF PROTEOME RESEARCH

Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases

(2020) Michael Groot et al.   Cells

Isolation of cancer-derived extracellular vesicle subpopulations by a size-selective microfluidic platform

(2020) Zheyuan Chen et al.   Biomicrofluidics

ExoBCD: a comprehensive database for exosomal biomarker discovery in breast cancer

(2020) Xuanyi Wang et al.   BRIEFINGS IN BIOINFORMATICS

Lysosomal‐associated transmembrane protein 4B regulates ceramide‐induced exosome release

(2020) Kohei Yuyama et al.   FASEB JOURNAL

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation

(2020) Ann L. Wozniak et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial DNA in extracellular vesicles declines with age

(2020) Stephanie Lazo et al.   AGING CELL

Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential

(2020) Niaz Z. Khan et al.   BRAIN BEHAVIOR AND IMMUNITY

Dying neurons conduct repair processes in the injured brain through osteopontin expression in cooperation with infiltrated blood monocytes

(2020) Jiawei An et al.   GLIA

Tumor heterogeneity and the potential role of liquid biopsy in bladder cancer

(2020) Hai‐Ming Huang et al.   Cancer Communications

Decreased salivary concentration of CD9 and CD81 exosome-related tetraspanins may be associated with the periodontal clinical status

(2019) S I Tobón-Arroyave et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Generation of the heterogeneity of extracellular vesicles by membrane organization and sorting machineries

(2019) Yoichiro Harada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intercellular Communication between Hepatic Cells in Liver Diseases

(2019) Keisaku Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transfer of Functional Cargo in Exomeres

(2019) Qin Zhang et al.   Cell Reports

Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer

(2019) Judit Szilvia Keserű et al.   JOURNAL OF BIOTECHNOLOGY

Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli

(2019) Heedoo Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

(2019) Dongsic Choi et al.   ACS Nano

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

(2019) Morayma M Temoche-Diaz et al.   eLife

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia

(2019) Valerie Sackmann et al.   Frontiers in Molecular Neuroscience

DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology

(2019) Elisa Lázaro-Ibáñez et al.   Journal of Extracellular Vesicles

Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

(2019) Su Chul Jang et al.   Journal of Extracellular Vesicles

Exosomes in intercellular communication and implications for osteoarthritis

(2019) Sabha Asghar et al.   RHEUMATOLOGY

Detection and Characterization of Different Brain-Derived Subpopulations of Plasma Exosomes by Surface Plasmon Resonance Imaging

(2018) Silvia Picciolini et al.   ANALYTICAL CHEMISTRY

Extracellular vesicles : lipids as key components of their biogenesis and functions

(2018) Michel Record et al.   JOURNAL OF LIPID RESEARCH

Subpopulations of extracellular vesicles and their therapeutic potential

(2018) Cecilia Lässer et al.   MOLECULAR ASPECTS OF MEDICINE

Molecular mechanism to recruit galectin-3 into multivesicular bodies for polarized exosomal secretion

(2018) Sebastian Bänfer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells

(2018) Kenneth P. Hough et al.   Redox Biology

Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions

(2018) Kevin Thurley et al.   Cell Systems

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Arrestin-Domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles

(2018) Sushma Anand et al.   PROTEOMICS

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

(2017) Shengli Li et al.   NUCLEIC ACIDS RESEARCH

miRandola 2017: a curated knowledge base of non-invasive biomarkers

(2017) Francesco Russo et al.   NUCLEIC ACIDS RESEARCH

New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes

(2017) M. Rohan Fernando et al.   PLoS One

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of exosome-mediated intercellular communication in vascular remodeling

(2017) Sheng-An Su et al.   Oncotarget

Exosomes in immunoregulation of chronic lung diseases

(2016) K. P. Hough et al.   ALLERGY

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4+T-cell responses

(2016) Yingping Xu et al.   IMMUNOLOGY

Role of Alix in miRNA packaging during extracellular vesicle biogenesis

(2016) ALESSANDRA IAVELLO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system

(2016) Virgilio J. J. Cadete et al.   JOURNAL OF PHYSIOLOGY-LONDON

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Functional prostate-specific membrane antigen is enriched in exosomes from prostate cancer cells

(2014) TIANCHENG LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes

(2014) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ComplexN-Linked Glycans Serve as a Determinant for Exosome/Microvesicle Cargo Recruitment

(2014) Yaxuan Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation

(2012) Chris MacDonald et al.   EMBO REPORTS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

ALIX-CHMP4 interactions in the human ESCRT pathway

(2008) J. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE