Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia
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Title
Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia
Authors
Keywords
-
Journal
Frontiers in Molecular Neuroscience
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-08-29
DOI
10.3389/fnmol.2019.00200
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Note: Only part of the references are listed.- Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes
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- (2018) Maitrayee Sardar Sinha et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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- (2018) Brittany A. Law et al. FASEB JOURNAL
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- (2018) Owen Scudamore et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
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- (2018) Shi Zhang et al. NEUROBIOLOGY OF AGING
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- (2018) Thomas Juan et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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- (2018) Natascha Fussi et al. Cell Death & Disease
- Label-free detection of hypoxia-induced extracellular vesicle secretion from MCF-7 cells
- (2018) Tugba Kilic et al. Scientific Reports
- Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease
- (2017) James A. Duce et al. Molecular Neurodegeneration
- Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells
- (2017) Valerie Sackmann et al. NEUROBIOLOGY OF AGING
- Serum lipid alterations in GBA -associated Parkinson's disease
- (2017) Leonor Correia Guedes et al. PARKINSONISM & RELATED DISORDERS
- Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
- (2017) Michael V. Airola et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipids in exosomes: Current knowledge and the way forward
- (2017) Tore Skotland et al. PROGRESS IN LIPID RESEARCH
- Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein
- (2017) Marion Delenclos et al. Frontiers in Neuroscience
- An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons
- (2017) Lotta Agholme et al. JOURNAL OF ALZHEIMERS DISEASE
- Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes
- (2017) Jakob Domert et al. PLoS One
- Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein
- (2016) Kathrin Guitart et al. GLIA
- Associations between plasma ceramides and cognitive and neuropsychiatric manifestations in Parkinson's disease dementia
- (2016) Yi Xing et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Regulation of sphingomyelin metabolism
- (2016) Kamil Bienias et al. Pharmacological Reports
- Hypoxia metabolism in ageing
- (2015) Alessandro Valli et al. Aging-US
- Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
- (2015) Anne Stuendl et al. BRAIN
- Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH
- (2015) Manoj Amrutkar et al. FASEB JOURNAL
- Lipid rafts involvement in the pathogenesis of Parkinson s disease
- (2015) Shin-ichiro Kubo Frontiers in Bioscience-Landmark
- Dihydroceramides: From Bit Players to Lead Actors
- (2015) Monowarul Mobin Siddique et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- No evidence for substrate accumulation in Parkinson brains withGBAmutations
- (2015) Matthew E. Gegg et al. MOVEMENT DISORDERS
- Oxidative stress and Parkinson’s disease
- (2015) Javier Blesa et al. Frontiers in Neuroanatomy
- Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties
- (2015) Mariana Figuera-Losada et al. PLoS One
- Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
- (2014) Karen E. Murphy et al. BRAIN
- Biogenesis and secretion of exosomes
- (2014) Joanna Kowal et al. CURRENT OPINION IN CELL BIOLOGY
- The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes
- (2014) Belinda B. Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acceleration of α-Synuclein Aggregation by Exosomes
- (2014) Marie Grey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia
- (2014) Fernando D. Testai et al. JOURNAL OF NEUROCHEMISTRY
- Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
- (2014) Michael B. Dinkins et al. NEUROBIOLOGY OF AGING
- Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
- (2013) Marina Colombo et al. JOURNAL OF CELL SCIENCE
- Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
- (2013) LiZe Gu et al. Journal of Neuroinflammation
- Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity
- (2013) Wei Xiang et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules
- (2013) Anand Ramteke et al. MOLECULAR CARCINOGENESIS
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- (2013) Sarah K. Abbott et al. MOVEMENT DISORDERS
- Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study
- (2013) Michelle M. Mielke et al. PLoS One
- Role of Oxidative Stress in Parkinson's Disease
- (2013) Onyou Hwang Experimental Neurobiology
- Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein
- (2012) Eun-Jin Bae et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2012) Hamish W King et al. BMC CANCER
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- (2012) Lars Löfgren et al. JOURNAL OF LIPID RESEARCH
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- (2012) S. Nath et al. JOURNAL OF NEUROSCIENCE
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
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- (2012) Maria Francesca Baietti et al. NATURE CELL BIOLOGY
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- (2012) K. C. Luk et al. SCIENCE
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- Dihydroceramide-based Response to Hypoxia
- (2011) Cecilia M. Devlin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unknown
- (2011) Noemi Fabelo et al. MOLECULAR MEDICINE
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- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
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- (2011) Danni Cheng et al. PLoS One
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- (2010) Thomas Näsström et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2009) V. Menuz et al. SCIENCE
- CELL BIOLOGY: No ESCRTs for Exosomes
- (2008) M. Marsh et al. SCIENCE
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- (2008) K. Trajkovic et al. SCIENCE
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