Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging

Accumulation of pTreg cells is detrimental in late‐onset (aged) mouse model of multiple sclerosis

(2022) Weikan Wang et al.   AGING CELL

MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection

(2022) Erietta Stelekati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-Expression of TIGIT and Helios Marks Immunosenescent CD8+ T Cells During Aging

(2022) Daan K. J. Pieren et al.   Frontiers in Immunology

Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands

(2022) Claudia M. Trujillo-Vargas et al.   GeroScience

TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection

(2022) Lam Ngoc Thao Nguyen et al.   JOURNAL OF CELL SCIENCE

Genetic, parental and lifestyle factors influence telomere length

(2022) Sergio Andreu-Sánchez et al.   Communications Biology

An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory

(2022) Alessio Lanna et al.   NATURE CELL BIOLOGY

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

(2021) Louise M. C. Webb et al.   AGING CELL

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

(2021) Xiaoping Hong et al.   Frontiers in Immunology

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

(2021) Luisa Morales-Nebreda et al.   JCI Insight

Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans

(2021) Ricardo I. Martínez‐Zamudio et al.   AGING CELL

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

(2021) Anthony Lagnado et al.   EMBO JOURNAL

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

Hallmarks of T cell aging

(2021) Maria Mittelbrunn et al.   NATURE IMMUNOLOGY

Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity

(2021) Anne-Sophie Rousseau et al.   Frontiers in Physiology

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

(2021) Sarah S. Gabriel et al.   IMMUNITY

Treg and IL-1 receptor type 2-expressing CD4+ T cell-deleted CD4+ T cell fraction prevents the progression of age-related hearing loss in a mouse model

(2021) Hiroshi Iwai et al.   JOURNAL OF NEUROIMMUNOLOGY

Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation

(2021) Cory J. Knudson et al.   JOURNAL OF VIROLOGY

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients

(2021) Maria C. Ramello et al.   Frontiers in Immunology

Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics

(2021) Erica C. Lorenzo et al.   AGING CELL

Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox

(2021) David Y. Oh et al.   IMMUNITY

Mechanisms underpinning poor antibody responses to vaccines in ageing

(2021) Jia Le Lee et al.   IMMUNOLOGY LETTERS

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

(2021) Mojdeh Shakiba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD29 Enriches for Cytotoxic Human CD4+ T Cells

(2021) Benoît P. Nicolet et al.   JOURNAL OF IMMUNOLOGY

Understanding T cell aging to improve anti-viral immunity

(2021) Huimin Zhang et al.   Current Opinion in Virology

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

(2020) Anna Śledzińska et al.   IMMUNITY

Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells

(2020) M. Samiul Alam et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Old age‐associated enrichment of peripheral T regulatory cells and altered redox status in pulmonary tuberculosis patients

(2020) Manju Namdeo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

(2020) Marisa Stebegg et al.   eLife

FOXO1 deficiency impairs proteostasis in aged T cells

(2020) Jun Jin et al.   Science Advances

T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome

(2020) Dan Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

(2020) Maha Almanan et al.   Science Advances

The Transcription Factor TCF1 in T Cell Differentiation and Aging

(2020) Chulwoo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DCAF1 regulates Treg senescence via the ROS axis during immunological aging

(2020) Zengli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection

(2020) Ioana Sandu et al.   Nature Communications

Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases

(2020) Ying Jen Chen et al.   Life-Basel

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

(2019) Lisa Schmidleithner et al.   IMMUNITY

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

(2019) Deepali V. Sawant et al.   NATURE IMMUNOLOGY

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

(2019) Yehezqel Elyahu et al.   Science Advances

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

(2019) Arsun Bektas et al.   Aging-US

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

(2019) Kosuke Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

(2019) Chulwoo Kim et al.   Cell Reports

Cell generation dynamics underlying naive T-cell homeostasis in adult humans

(2019) Jeff E. Mold et al.   PLOS BIOLOGY

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

(2019) Yangjing Zhao et al.   Cellular & Molecular Immunology

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

(2018) Aurélie Durand et al.   Nature Communications

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

(2018) Xia Liu et al.   Nature Communications

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

(2018) Stella Lukas Yani et al.   Frontiers in Immunology

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

(2018) Hiroyuki Yoshitomi et al.   Nature Communications

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

(2018) Noga Ron-Harel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

(2018) Chulwoo Kim et al.   Cell Reports

Transcriptional and epigenetic regulation of T cell hyporesponsiveness

(2017) Renata M. Pereira et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs

(2017) John S Davies et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA

(2017) Yuan Tian et al.   Nature Communications

Capacity of tTreg generation is not impaired in the atrophied thymus

(2017) Jiyoung Oh et al.   PLOS BIOLOGY

The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells

(2017) Anna E. Oja et al.   Frontiers in Immunology

Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis

(2017) Johannes Fessler et al.   Frontiers in Immunology

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

(2017) Arata Takeuchi et al.   Frontiers in Immunology

CD57 in human natural killer cells and T-lymphocytes

(2016) Hassen Kared et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs

(2016) Zhenke Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus

(2016) Tiziano Donnarumma et al.   Cell Reports

The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

(2016) Kankana Bardhan et al.   Frontiers in Immunology

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

(2016) Julie S Lefebvre et al.   Scientific Reports

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

(2016) Si-Young Cho et al.   Scientific Reports

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

CRTAM determines the CD4+cytotoxic T lymphocyte lineage

(2015) Arata Takeuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A CD153+CD4+T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

(2015) Suhail Tahir et al.   JOURNAL OF IMMUNOLOGY

IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age

(2015) Jana Raynor et al.   JOURNAL OF IMMUNOLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition

(2015) Brian M Weist et al.   NATURE IMMUNOLOGY

Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors

(2015) Nicolas Thiault et al.   NATURE IMMUNOLOGY

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

(2015) Ben J. E. Raveney et al.   Nature Communications

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

(2015) Peter T. Sage et al.   Cell Reports

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells

(2015) Hiroshi Iwai et al.   Immunity & Ageing

CD28 Negative T Cells: Is Their Loss Our Gain?

(2014) D. Mou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

West Nile Virus-Specific CD4 T Cells Exhibit Direct Antiviral Cytokine Secretion and Cytotoxicity and Are Sufficient for Antiviral Protection

(2014) J. D. Brien et al.   JOURNAL OF IMMUNOLOGY

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

(2014) C. S. Lages et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Aging is associated with increased regulatory T-cell function

(2013) Sanjay K. Garg et al.   AGING CELL

Characterization of CD4+CD28null T cells in patients with coronary artery disease and individuals with risk factors for atherosclerosis

(2013) Fábio Haach Téo et al.   CELLULAR IMMUNOLOGY

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Extrathymic induction of Foxp3+regulatory T cells declines with age in a T-cell intrinsic manner

(2013) Maxime Carpentier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Diversification and senescence of Foxp3+regulatory T cells during experimental autoimmune encephalomyelitis

(2013) Sharyn Tauro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Th17/Treg balance is disturbed during aging

(2013) Vanessa Schmitt et al.   EXPERIMENTAL GERONTOLOGY

Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

(2013) Michael A. Curran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8 + Dendritic Cell Trans Presentation of IL-15 to Naive CD8+ T Cells Produces Antigen-Inexperienced T Cells in the Periphery with Memory Phenotype and Function

(2013) T. Sosinowski et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells

(2013) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity

(2013) Bernardo Sgarbi Reis et al.   NATURE IMMUNOLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

(2013) Jana Raynor et al.   Frontiers in Immunology

When aging reaches CD4+ T-cells: phenotypic and functional changes

(2013) Marco Antonio Moro-García   Frontiers in Immunology

Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells

(2012) Lishi Sun et al.   AGING CELL

The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

(2012) Julie S. Lefebvre et al.   AGING CELL

Human regulatory T cells induce T-lymphocyte senescence

(2012) J. Ye et al.   BLOOD

Properties of end-stage human T cells defined by CD45RA re-expression

(2012) Sian M Henson et al.   CURRENT OPINION IN IMMUNOLOGY

Impairment of CD4+cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma

(2012) Junliang Fu et al.   HEPATOLOGY

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4+ Th cells cytotoxic by activating both perforin- and FasL-pathways

(2012) Koji Eshima et al.   IMMUNOLOGY LETTERS

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

(2012) Helge Frebel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of tumoricidal function in CD4+T cells is associated with concomitant memory and terminally differentiated phenotype

(2012) Daniel Hirschhorn-Cymerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation

(2012) Klaas P J M van Gisbergen et al.   NATURE IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accelerated Aging versus Rejuvenation of the Immune System in Heterochronic Parabiosis

(2012) Iryna Pishel et al.   REJUVENATION RESEARCH

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system

(2011) Rebeca Alonso-Arias et al.   AGE

CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation

(2011) H. Z. Qui et al.   JOURNAL OF IMMUNOLOGY

Phenotype, Function, and Gene Expression Profiles of Programmed Death-1 hi CD8 T Cells in Healthy Human Adults

(2011) Jaikumar Duraiswamy et al.   JOURNAL OF IMMUNOLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Expansions of NK-like αβT cells with chronologic aging: Novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells

(2010) Abbe N. Vallejo et al.   AGEING RESEARCH REVIEWS

A Major Role for Bim in Regulatory T Cell Homeostasis

(2010) C. A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

(2009) Deborah M. Brown et al.   CELLULAR IMMUNOLOGY

The antigen-specific CD8+T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion

(2009) Catherine Haluszczak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+T cells during aging

(2009) Elaine Agius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

The frequency of regulatory CD3+ CD8+ CD28− CD25+ T lymphocytes in human peripheral blood increases with age

(2008) Rita Simone et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology