Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

Once a Treg, always a Treg?

(2014) Deepali V. Sawant et al.   IMMUNOLOGICAL REVIEWS

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

(2014) K. B. Vang et al.   JOURNAL OF IMMUNOLOGY

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

Opposing chemokine gradients control human thymocyte migration in situ

(2013) Joanna Halkias et al.   JOURNAL OF CLINICAL INVESTIGATION

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

(2013) Jaehak Oh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+regulatory T cell development via the CD27–CD70 pathway

(2013) Jonathan M. Coquet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Temporal Patterns of T Cell Receptor Signaling During Positive Versus Negative Selection in Situ

(2013) H. J. Melichar et al.   Science Signaling

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

Dendritic Cells Control CD4+CD25+ Treg Cell Suppressor Function In Vitro through Juxtacrine Delivery of IL-2

(2012) Katarina Kulhankova et al.   PLoS One

T-cell receptor affinity in thymic development

(2011) Amy E. Moran et al.   IMMUNOLOGY

Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus

(2010) E. Roman et al.   JOURNAL OF IMMUNOLOGY

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes

(2009) Lauren I. Richie Ehrlich et al.   IMMUNITY

TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes

(2009) Monica W.L. Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction

(2009) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA