Effector-Triggered Immunity

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

(2022) Wanyan Deng et al.   NATURE

M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome

(2022) Sahana D. Rao et al.   Nature Chemical Biology

Influenza A Virus Infection Activates NLRP3 Inflammasome through Trans-Golgi Network Dispersion

(2022) Kannu Priya Pandey et al.   Viruses-Basel

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

(2022) Rémi Planès et al.   MOLECULAR CELL

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

(2022) Doris L. LaRock et al.   NATURE

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

(2022) Kim S. Robinson et al.   SCIENCE

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

(2022) Rhea Nadkarni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

(2022) Che A. Stafford et al.   NATURE

Cryo-EM structures of the active NLRP3 inflammasome disc

(2022) Le Xiao et al.   NATURE

Distinct changes in endosomal composition promote NLRP3 inflammasome activation

(2022) Zhirong Zhang et al.   NATURE IMMUNOLOGY

Effector-triggered immunity in mammalian antiviral defense

(2022) Megan H. Orzalli et al.   TRENDS IN IMMUNOLOGY

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

(2021) Zhijun Liu et al.   IMMUNITY

Diverse viral proteases activate the NLRP1 inflammasome

(2021) Brian V Tsu et al.   eLife

Pattern-recognition receptors are required for NLR-mediated plant immunity

(2021) Minhang Yuan et al.   NATURE

CARD8 is an inflammasome sensor for HIV-1 protease activity

(2021) Qiankun Wang et al.   SCIENCE

SAMHD1 … and Viral Ways around It

(2021) Janina Deutschmann et al.   Viruses-Basel

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

(2021) Megan H. Orzalli et al.   IMMUNITY

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

(2021) L. Robert Hollingsworth et al.   NATURE

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

(2021) Justin M. Hansen et al.   CELL

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

(2021) Giovanni Luchetti et al.   Cell Host & Microbe

Molecular mechanisms of nonself nucleic acid recognition by the innate immune system

(2021) Carina C. Oliveira Mann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

(2021) Daisy X Ji et al.   eLife

Self-guarding of MORC3 enables virulence factor-triggered immunity

(2021) Moritz M. Gaidt et al.   NATURE

RPS5-Mediated Disease Resistance: Fundamental Insights and Translational Applications

(2020) Sarah E. Pottinger et al.   Annual Review of Phytopathology

To catch a thief: regulated RIPK1 post-translational modifications as a fail-safe system to detect and overcome pathogen subversion of immune signaling

(2020) Lance W Peterson et al.   CURRENT OPINION IN MICROBIOLOGY

The Speckled Protein (SP) Family: Immunity’s Chromatin Readers

(2020) Isabella Fraschilla et al.   TRENDS IN IMMUNOLOGY

SAMHD1 Functions and Human Diseases

(2020) Si’Ana A. Coggins et al.   Viruses-Basel

A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8

(2020) Hiroshi Ashida et al.   EMBO JOURNAL

Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

(2020) Yong Hwan Park et al.   NATURE IMMUNOLOGY

The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection

(2020) Milagros Collados Rodríguez et al.   VIRUS RESEARCH

Control of Viral Infection by Natural Killer Cell Inhibitory Receptors

(2020) Bijal A. Parikh et al.   Cell Reports

Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation

(2020) Xin Liu et al.   Cell Host & Microbe

Integration of innate immune signaling by caspase-8 cleavage of N4BP1

(2020) Alexander D. Gitlin et al.   NATURE

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

(2020) Kim S. Robinson et al.   SCIENCE

The later stages of viral infection: An undiscovered country of host dependency factors

(2020) Cason R. King et al.   PLoS Pathogens

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

(2020) Josh Sun et al.   EBioMedicine

Bacterial Retrons Function In Anti-Phage Defense

(2020) Adi Millman et al.   CELL

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

(2020) Raoul Martin et al.   SCIENCE

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

ISG15: It's Complicated

(2019) John V. Dzimianski et al.   JOURNAL OF MOLECULAR BIOLOGY

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

(2019) Simona Sivori et al.   Cellular & Molecular Immunology

Activation of the endoplasmic reticulum stress response impacts the NOD1 signaling pathway

(2019) Jonathan M. Mendez et al.   INFECTION AND IMMUNITY

Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress

(2019) Raphael Molinaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

NLR singletons, pairs, and networks: evolution, assembly, and regulation of the intracellular immunoreceptor circuitry of plants

(2019) Hiroaki Adachi et al.   CURRENT OPINION IN PLANT BIOLOGY

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Programmed Cell Death in the Evolutionary Race against Bacterial Virulence Factors

(2019) Carolyn A. Lacey et al.   Cold Spring Harbor Perspectives in Biology

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

(2019) Patrick S Mitchell et al.   CURRENT OPINION IN IMMUNOLOGY

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

(2019) Panfeng Tao et al.   NATURE

Effector-triggered immunity and pathogen sensing in metazoans

(2019) Natasha Lopes Fischer et al.   Nature Microbiology

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response

(2018) John T. Crowl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Control in Virus-Infected Cells

(2018) Noam Stern-Ginossar et al.   Cold Spring Harbor Perspectives in Biology

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors

(2018) Hui Sun et al.   Nature Microbiology

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages

(2018) Dhruv Chauhan et al.   Cell Reports

Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells

(2017) David H. Raulet et al.   IMMUNOLOGICAL REVIEWS

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events

(2017) Jonathan M. Urbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors

(2017) Justin A. De Leon et al.   Cell Reports

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen

(2017) Kevin C Barry et al.   eLife

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens

(2016) Panagiotis F. Sarris et al.   BMC BIOLOGY

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus

(2016) Elizabeth Sloan et al.   JOURNAL OF VIROLOGY

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Interactions between the microbiota and pathogenic bacteria in the gut

(2016) Andreas J. Bäumler et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread

(2016) Thomas Kroj et al.   NEW PHYTOLOGIST

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

(2016) Nieves Peltzer et al.   TRENDS IN CELL BIOLOGY

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

(2016) Joseph Chavarría-Smith et al.   PLoS Pathogens

Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans

(2016) Read Pukkila-Worley   PLoS Pathogens

A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

(2016) Trever T Greene et al.   eLife

A Receptor Pair with an Integrated Decoy Converts Pathogen Disabling of Transcription Factors to Immunity

(2015) Clémentine Le Roux et al.   CELL

A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors

(2015) Panagiotis F. Sarris et al.   CELL

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

The NAIP/NLRC4 inflammasomes

(2015) Russell E Vance   CURRENT OPINION IN IMMUNOLOGY

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication

(2015) Lorena S. Ver et al.   JOURNAL OF VIROLOGY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

(2015) Adrien Decque et al.   NATURE IMMUNOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Inhibition of host cell translation elongation byLegionella pneumophilablocks the host cell unfolded protein response

(2015) Andrew D. Hempstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis

(2015) Alan M. Copenhaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella suppresses the host unfolded protein response via multiple mechanisms

(2015) Sean Treacy-Abarca et al.   Nature Communications

TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation

(2015) Federica Ferri et al.   Nature Communications

Analysis of the SUMO2 Proteome during HSV-1 Infection

(2015) Elizabeth Sloan et al.   PLoS Pathogens

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

Convergent Targeting of a Common Host Protein-Network by Pathogen Effectors from Three Kingdoms of Life

(2014) Ralf Weßling et al.   Cell Host & Microbe

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling

(2014) Harald Bielig et al.   PLoS Pathogens

The Frustrated Host Response to Legionella pneumophila Is Bypassed by MyD88-Dependent Translation of Pro-inflammatory Cytokines

(2014) Seblewongel Asrat et al.   PLoS Pathogens

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis

(2014) Stella Cesari et al.   Frontiers in Plant Science

Hijacking of Rho GTPases during bacterial infection

(2013) Emmanuel Lemichez et al.   EXPERIMENTAL CELL RESEARCH

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

(2013) A. Marijke Keestra et al.   NATURE

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR

(2013) Stanimir S Ivanov et al.   NATURE IMMUNOLOGY

Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens

(2013) Bruno Lemaitre et al.   NATURE REVIEWS MICROBIOLOGY

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Rules of Engagement: Molecular Insights from Host-Virus Arms Races

(2012) Matthew D. Daugherty et al.   Annual Review of Genetics

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

Host Translational Inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an Immune Response in Caenorhabditis elegans

(2012) Deborah L. McEwan et al.   Cell Host & Microbe

C. elegans Detects Pathogen-Induced Translational Inhibition to Activate Immune Signaling

(2012) Tiffany L. Dunbar et al.   Cell Host & Microbe

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

Activation of Host Mitogen-Activated Protein Kinases by Secreted Legionella pneumophila Effectors That Inhibit Host Protein Translation

(2012) Mary F. Fontana et al.   INFECTION AND IMMUNITY

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Pathogen-Derived Effectors Trigger Protective Immunity via Activation of the Rac2 Enzyme and the IMD or Rip Kinase Signaling Pathway

(2011) Laurent Boyer et al.   IMMUNITY

Two signal models in innate immunity

(2011) Mary F. Fontana et al.   IMMUNOLOGICAL REVIEWS

Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

(2011) Johan Tisserand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes

(2011) Jia-Xing Yue et al.   NEW PHYTOLOGIST

CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain

(2011) Andrea D'Osualdo et al.   PLoS One

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages

(2010) Andrea J. McCoy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo

(2010) Marina Babić et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Activation of an Arabidopsis Resistance Protein Is Specified by the in Planta Association of Its Leucine-Rich Repeat Domain with the Cognate Oomycete Effector

(2010) K. V. Krasileva et al.   PLANT CELL

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Salmonella Typhimurium Type III Secretion Effectors Stimulate Innate Immune Responses in Cultured Epithelial Cells

(2009) Vincent M. Bruno et al.   PLoS Pathogens

KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

(2008) Shinya Kamitani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors

(2008) R. A.L. van der Hoorn et al.   PLANT CELL

GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors

(2008) Atsuko Fukazawa et al.   PLoS Pathogens