Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?

(2021) Zhibin Zhang et al.   Cancer Immunology Research

Knocking ’em Dead: Pore-Forming Proteins in Immune Defense

(2020) Xing Liu et al.   Annual Review of Immunology

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

(2019) Wei Peng et al.   PLoS One

Innate Lymphoid Cells in Mucosal Immunity

(2019) Santosh K. Panda et al.   Frontiers in Immunology

Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation

(2019) Jayne L. Watson et al.   mBio

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

(2018) Ibrahim A Khalil et al.   LANCET INFECTIOUS DISEASES

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

(2018) R. Blake Richardson et al.   Nature Microbiology

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

(2017) Peng Li et al.   NATURE

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

(2017) Kinlin L. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

(2017) Siyun Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

(2017) Anthony S. Piro et al.   mBio

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

(2016) Van Trung Chu et al.   BMC BIOTECHNOLOGY

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

(2016) Sofya S. Perelman et al.   PLoS Pathogens

Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation

(2016) Maarten F. de Jong et al.   Nature Microbiology

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners

(2015) H. F. O'Connor et al.   EMBO REPORTS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

(2015) G. Gasteiger et al.   SCIENCE

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

(2014) Michael Walch et al.   CELL

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

ShigellaIpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages

(2014) Shiho Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

(2013) Asif S Tulah et al.   BMC Medical Genetics

Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase

(2013) A. F. A. Keszei et al.   MOLECULAR AND CELLULAR BIOLOGY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort

(2012) Ben D. Spycher et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The Bimodal Lifestyle of Intracellular Salmonella in Epithelial Cells: Replication in the Cytosol Obscures Defects in Vacuolar Replication

(2012) Preeti Malik-Kale et al.   PLoS One

The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response

(2011) Patrick Kaiser et al.   IMMUNOLOGICAL REVIEWS

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR

(2011) Jinho Yu et al.   PEDIATRIC PULMONOLOGY

Cardiolipin membrane domains in prokaryotes and eukaryotes

(2009) Eugenia Mileykovskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

(2008) G. N. Schroeder et al.   CLINICAL MICROBIOLOGY REVIEWS

Structure of a Shigella effector reveals a new class of ubiquitin ligases

(2008) Yongqun Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

(2008) Alexander U Singer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues

(2007) Stacy Carl-McGrath et al.   PATHOLOGY