Article
Biochemistry & Molecular Biology
Emily M. Kibby, Amy N. Conte, A. Maxwell Burroughs, Toni A. Nagy, Jose A. Vargas, Lindsay A. Whalen, L. Aravind, Aaron T. Whiteley
Summary: Bacteria possess immune systems that can counter phage infection, and certain genes involved in these systems are similar to those found in eukaryotes, suggesting horizontal gene transfer. This study shows that bacteria also have proteins containing a NACHT module which defend against phages, and these proteins share similarities with human NLRs, indicating a shared signaling mechanism. The presence of NACHT module-containing proteins in bacteria establishes their ancient role as mediators of innate immunity.
Article
Biochemistry & Molecular Biology
Nanthip Prathumsap, Benjamin Ongnok, Thawatchai Khuanjing, Apiwan Arinno, Chayodom Maneechote, Nattayaporn Apaijai, Titikorn Chunchai, Busarin Arunsak, Sasiwan Kerdphoo, Sornram Janjek, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Aberrations in programmed cell death, including autophagy/mitophagy, apoptosis, necroptosis, pyroptosis, and ferroptosis, are observed in doxorubicin-induced cardiotoxicity (DIC). Vagus nerve stimulation (VNS) has been shown to protect against cardiomyocyte death through acetylcholine (ACh) release, but its role in DIC and underlying mechanisms remain unknown.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Qi Meng, Binbin Ding, Ping'an Ma, Jun Lin
Summary: Programmed cell death (PCD) and immunogenic cell death (ICD) are important mechanisms in cancer therapy, and understanding their relationship is significant for tumor treatments. This review describes the interrelationship between PCD and ICD using nanomedicines as examples. It provides an overview of PCD patterns, explores the link between apoptosis and ICD, introduces non-apoptotic signaling pathways and their relationship with ICD, and summarizes the potential application of PCD and ICD in the development of new nanomaterials. The review aims to deepen understanding, extend biomedical applications, and promote progress in clinical tumor therapy.
Article
Immunology
Sihui Zhu, Lijuan Bian, Jia Lv, Baorui Liu, Jie Shen
Summary: This case report describes a male patient who developed non-bacterial cystitis after receiving immunotherapy, with recurrent urinary tract discomfort leading to surgery. Multiple urine cultures and cystoscopy biopsy confirmed the diagnosis of non-bacterial bladder inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study found that donepezil protects against trastuzumab-induced cardiotoxicity by reducing mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte death, leading to improved left ventricular function through activation of muscarinic acetylcholine receptors. This provides a new intervention strategy for treating trastuzumab-induced cardiotoxicity.
MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Emma C. Tovey Crutchfield, Sarah E. Garnish, Joanne M. Hildebrand
Summary: Necroptosis is an inflammatory form of cell death evolved to defend against pathogens. Small molecules targeting RIPK1 kinase activity have shown promise in disease models, triggering significant investment in necroptosis blocking drugs. Understanding the role of MLKL in murine disease models is crucial for identifying human indications for targeted drug therapies.
Review
Biochemistry & Molecular Biology
Sung Un Huh
Summary: Plants have metaCaspases instead of caspases, which play critical roles in programmed cell death during plant development and defense responses. The diversity in the number of metaCaspases in different plant species suggests varying functions due to diverse evolutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Alok A. Khorana, Jennell Palaia, Lisa Rosenblatt, Radhika Pisupati, Ning Huang, Chi Nguyen, John Barron, Kerrin Gallagher, T. Christopher Bond
Summary: This study assessed the incidence and risk factors of venous thromboembolism (VTE) in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI). The study found that ICI-based regimens were associated with lower risk of VTE compared to chemotherapy (chemo), while the risk of VTE with ICI+chemo regimens was similar to chemo. Previous radiation and severe obesity were also associated with VTE.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, Research & Experimental
Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami, Kazuhisa Takahashi
Summary: This study investigated the clinical characteristics and predictive factors in patients with advanced NSq-NSCLC who underwent long-term PEM maintenance therapy. Results showed that ALC, NLR, and PD-1 expression are predictive biomarkers indirectly related to tumor immunity and can provide useful predictive information on the long-term response to PEM in patients with NSq-NSCLC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tereso J. Guzman, Martina Duefer, Mats Wiedemann, Roxana Olguin-Alor, Gloria Soldevila, Carmen M. Gurrola-Diaz
Summary: The study found that gamma-conglutin can protect cells against cell death induced by oxidative stress or lipotoxicity by reducing ROS, especially with a certain degree of protection for HepG2 hepatocytes and MIN6 insulin-producing cells. Additionally, gamma-conglutin appears to promote beta-cell rest, which may help prevent beta-cell exhaustion in chronic hyperglycemia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Eunok Im, Yung Hyun Choi, Nam Deuk Kim
Summary: Bile acids are important in lipid digestion and absorption, and have been found to be tumor suppressors. This review comprehensively summarizes the literature on bile acid-induced programmed cell death and the development of synthetic bile acid derivatives for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Microbiology
Maisem Laabei, Seana Duggan
Summary: Programmed cell death (PCD) and carbohydrate metabolism by-product transport both involve the cidABC and lrgAB operons in Staphylococcus aureus. New research shows that CidA and LrgA function as holins to support endolysin-induced lysis and also facilitate pyruvate uptake during microaerobic and anaerobic growth.
Article
Oncology
Liying Yang, Wei Zhang, Jujie Sun, Guanqun Yang, Siqi Cai, Fenghao Sun, Ligang Xing, Xiaorong Sun
Summary: This study investigated the relationship between the spatial interaction of PD-L1-positive tumor cells and T cells with specific functions and the recurrence of NSCLC, and optimized prognostic stratification. It was found that the number of PD-L1-positive tumor cells was higher in the tumor center compared to the invasion margin, while the number of T cells, especially PD-1-positive CD8 T cells, was lower. The proximity between CD8 T cells and PD-L1-positive tumor cells was closer, especially for exhausted CD8 T cells. The density and percentage of PD-1-positive CD4 T cells interacting with PD-L1-positive tumor cells were associated with recurrence, with increasing risk. Patients with low PD-1-positive CD4 count and high PD-1-positive CD4 density had a significantly higher risk of recurrence. The spatial proximity assessment of PD-1/PD-L1 contributes to a better understanding of tumor immune escape and provides prognostic information for NSCLC patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Dan Wu, Sheng Wang, Guocan Yu, Xiaoyuan Chen
Summary: Pyroptosis, a unique form of programmed cell death, has been closely associated with human diseases like inflammatory diseases and malignant tumors. Recent progress in cancer treatment based on nanoparticles-induced pyroptosis highlights design features and therapeutic advantages, while also proposing future directions in this emerging area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)