Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease

Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors

(2022) Zhibin Liang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 ( DNL747 ) for neurodegenerative disorders: Randomized, placebo‐controlled , double‐blind phase I/Ib studies in healthy subjects and patients

(2022) Maurits F. J. M. Vissers et al.   CTS-Clinical and Translational Science

cPKCγ ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation/reoxygenation by inhibiting ferroptosis

(2022) Haiping Wei et al.   NEUROSCIENCE RESEARCH

Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death

(2022) Andrew M. Lamade et al.   Redox Biology

Lapatinib ditosylate rescues memory impairment in D-galactose/ovariectomized rats: Potential repositioning of an anti-cancer drug for the treatment of Alzheimer's disease

(2021) Heba M. Mansour et al.   EXPERIMENTAL NEUROLOGY

Oxidative stress and regulated cell death in Parkinson’s disease

(2021) P.A. Dionísio et al.   AGEING RESEARCH REVIEWS

RIPK1 inhibitor ameliorates the MPP+/MPTP-induced Parkinson’s disease through the ASK1/JNK signalling pathway

(2021) Jing Liu et al.   BRAIN RESEARCH

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

(2021) Qing‐zhang Tuo et al.   MEDICINAL RESEARCH REVIEWS

Inhibition of Death-associated Protein Kinase 1 Attenuates Cis P-tau and Neurodegeneration in Traumatic Brain Injury

(2021) Nami Kim et al.   PROGRESS IN NEUROBIOLOGY

Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer’s Disease: Current Perspectives and Challenging Prospects

(2021) Heba M. Mansour et al.   NEUROSCIENCE

Novel insights into RIPK1 as a promising target for future Alzheimer’s disease treatment

(2021) Shang Li et al.   PHARMACOLOGY & THERAPEUTICS

Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions

(2021) Veronika Obsilova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

(2021) MahmoudM Khattab et al.   Neural Regeneration Research

Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats

(2021) Heba M. Mansour et al.   NEUROCHEMISTRY INTERNATIONAL

Response to inhibition of receptor‐interacting protein kinase 1 (RIPK1) in active plaque psoriasis: a randomized placebo‐controlled study

(2020) Kathleen Weisel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

(2020) Dongmei Chen et al.   JOURNAL OF PINEAL RESEARCH

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

(2020) Lauren Mifflin et al.   NATURE REVIEWS DRUG DISCOVERY

LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation

(2020) Ye Zhao et al.   NEUROBIOLOGY OF DISEASE

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

(2020) Hardy J. Rideout et al.   Frontiers in Neuroscience

Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone

(2020) Helene Ismail et al.   Antioxidants

Identification of the Raf kinase inhibitor TAK‐632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3

(2019) Xiaofei Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting RIPK1 for the treatment of human diseases

(2019) Alexei Degterev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

(2019) Nami Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roscovitine, an experimental CDK5 inhibitor, causes delayed suppression of microglial, but not astroglial recruitment around intracerebral dopaminergic grafts

(2019) Nikola Tomov et al.   EXPERIMENTAL NEUROLOGY

The second generation mixed lineage kinase-3 (MLK3) inhibitor CLFB-1134 protects against neurotoxin-induced nigral dopaminergic neuron loss

(2019) Elizabeth M. Kline et al.   EXPERIMENTAL NEUROLOGY

RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease

(2019) Qing-Song Lin et al.   LABORATORY INVESTIGATION

Apoptosis Signal Regulating Kinase 1 Deletion Mitigates the α-Synuclein Pre-formed Fibril Propagation Model in Mice

(2019) Jie Zhang et al.   NEUROBIOLOGY OF AGING

Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson’s disease model mice

(2019) Junge Zhu et al.   BRAIN RESEARCH

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

Brain penetrant kinase inhibitors: Learning from kinase neuroscience discovery

(2018) Yuan Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Repurposing anticancer drugs for targeting necroptosis

(2018) Simone Fulda   CELL CYCLE

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis

(2018) Huyan Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms

(2018) Amaly Nokkari et al.   PROGRESS IN NEUROBIOLOGY

Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms

(2018) Conor Owens-Walton et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

(2018) Rongni He et al.   Frontiers in Aging Neuroscience

The Parkinson Pandemic—A Call to Action

(2018) E. Ray Dorsey et al.   JAMA Neurology

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke

(2018) Wei Li et al.   NEUROSCIENCE

MicroRNA-26a/Death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson’s disease

(2018) Ying Su et al.   BIOLOGICAL PSYCHIATRY

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

(2017) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

(2017) Kelby W. Wegner et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mixed – Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states

(2016) Siobhan M. Craige et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo

(2016) B Shutinoski et al.   CELL DEATH AND DIFFERENTIATION

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuroprotective Mechanisms Mediated by CDK5 Inhibition

(2016) Gohar Mushtaq et al.   CURRENT PHARMACEUTICAL DESIGN

The cell's dilemma, or the story of cell death: an entertainment in three acts

(2016) Douglas R. Green   FEBS Journal

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Current and experimental treatments of Parkinson disease: A guide for neuroscientists

(2016) Wolfgang Oertel et al.   JOURNAL OF NEUROCHEMISTRY

The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation

(2016) Weiguo Dong et al.   Journal of Neuroinflammation

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson’s Disease

(2016) Miguel Mendivil-Perez et al.   NEUROCHEMICAL RESEARCH

Physiological and Pharmacological Control of BAK, BAX, and Beyond

(2016) Mark P.A. Luna-Vargas et al.   TRENDS IN CELL BIOLOGY

More to Life than NF-κB in TNFR1 Signaling

(2016) Adrian T. Ting et al.   TRENDS IN IMMUNOLOGY

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats

(2016) Firas H. Kobeissy et al.   Frontiers in Neurology

Syndromic parkinsonism and dementia associated withOPA1missense mutations

(2015) Valerio Carelli et al.   ANNALS OF NEUROLOGY

Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson’s disease

(2015) BK. Binukumar et al.   MOLECULAR BIOLOGY OF THE CELL

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surviving apoptosis: life–death signaling in single cells

(2015) Deborah A. Flusberg et al.   TRENDS IN CELL BIOLOGY

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

(2015) Malek Najjar et al.   Cell Reports

SnapShot: Necroptosis

(2014) Wen Zhou et al.   CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

(2014) S Orozco et al.   CELL DEATH AND DIFFERENTIATION

Cannabis (Medical Marijuana) Treatment for Motor and Non–Motor Symptoms of Parkinson Disease

(2014) Itay Lotan et al.   CLINICAL NEUROPHARMACOLOGY

Endogenous Events Modulating Myogenic Regulation of Cerebrovascular Function

(2014) Debebe Gebremedhin et al.   Current Vascular Pharmacology

Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival

(2014) Chia-Lung Chuang et al.   HUMAN MOLECULAR GENETICS

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease

(2014) X.-H. Lu et al.   Science Translational Medicine

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Death Associated Protein Kinases: Molecular Structure and Brain Injury

(2013) Syam Nair et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

(2013) Sarah Huntwork-Rodriguez et al.   JOURNAL OF CELL BIOLOGY

PKC-β Exacerbates in vitro Brain Barrier Damage in Hyperglycemic Settings via Regulation of RhoA/Rho-kinase/MLC2 Pathway

(2013) Kirtiman Srivastava et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The New Small-Molecule Mixed-Lineage Kinase 3 Inhibitor URMC-099 Is Neuroprotective and Anti-Inflammatory in Models of Human Immunodeficiency Virus-Associated Neurocognitive Disorders

(2013) D. F. Marker et al.   JOURNAL OF NEUROSCIENCE

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

(2013) Frank Gillardon et al.   JOURNAL OF NEUROSCIENCE METHODS

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Functional recovery and alterations in the expression and localization of protein kinase C following voluntary exercise in rat with cerebral infarction

(2013) Kenmei Mizutani et al.   NEUROLOGICAL SCIENCES

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

(2013) D. Martin Watterson et al.   PLoS One

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

Alarmins, inflammasomes and immunity

(2013) DavidM Ojcius et al.   Biomedical Journal

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

(2012) Joost CM Uitdehaag et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

(2012) José M. Bravo-San Pedro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury

(2012) Angela M. Boutté et al.   ELECTROPHORESIS

In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system

(2012) Joy D. Guingab-Cagmat et al.   ELECTROPHORESIS

Mitochondria and Programmed Cell Death in Parkinson's Disease: Apoptosis and Beyond

(2011) Celine Perier et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutations inLRRK2increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

(2011) Dario C. Angeles et al.   HUMAN MUTATION

Bcl-xLregulates mitochondrial energetics by stabilizing the inner membrane potential

(2011) Ying-bei Chen et al.   JOURNAL OF CELL BIOLOGY

Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade

(2011) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

Is mPTP the gatekeeper for necrosis, apoptosis, or both?

(2010) Kathleen W. Kinnally et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKCα/PKCδ signaling

(2010) Gui-yun Cui et al.   BRAIN RESEARCH

Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation

(2010) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of RanBP 9/10 as Interacting Partners for Protein Kinase C (PKC)  /  and the D1 Dopamine Receptor: Regulation of PKC-Mediated Receptor Phosphorylation

(2010) E. B. Rex et al.   MOLECULAR PHARMACOLOGY

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

(2010) En Huang et al.   NATURE CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions

(2009) G. Cuny   CURRENT PHARMACEUTICAL DESIGN

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease

(2009) Masahiro Nagao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Oxidized low-density lipoprotein induces matrix metalloproteinase-9 expression via a p42/p44 and JNK-dependent AP-1 pathway in brain astrocytes

(2008) Hui-Hsin Wang et al.   GLIA

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

MIXED LINEAGE KINASE INHIBITOR CEP- 1347 FAILS TO DELAY DISABILITY IN EARLY PARKINSON DISEASE

(2008) L. H. Wang et al.   NEUROLOGY

Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis

(2007) Yiping Rong et al.   Annual Review of Physiology