Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 281, Issue 1-2, Pages 51-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2009.02.375
Keywords
Apoptosis; JNK; Serine/treonine kinase; Calcium sensor protein; ER stress; Synucleopathy; Multiple system atrophy; Glial cytoplasmic inclusion
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The expression of hippocalcin, a calcium-sensor protein of the recoverin family, and mixed lineage kinase 2 (MLK2) in Lewy bodies (LBs) Was immunohistochemically examined in patients with Parkinson's disease (PD). Hippocalcin and MLK2 were colocalized in the halo, of LBs, and neither protein was detected in normal pigmented neurons. Since hippocalcin binds to the C-terminal region of MLK2 [Nagata K., Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T et A., The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J 1998; 17:149-1588.], it may constitutively activate MLK2. Both hippocalcin and MLK2 may be associated with the pathogenesis of PD. (C) 2009 Elsevier B.V. All rights reserved.
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