Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

(2022) De Huang et al.   NATURE CELL BIOLOGY

Physiological roles and metabolism of γ-aminobutyric acid (GABA) in parasitic protozoa

(2022) Rivo Yudhinata Brian Nugraha et al.   TRENDS IN PARASITOLOGY

Watercore Pear Fruit Respiration Changed and Accumulated γ-Aminobutyric Acid (GABA) in Response to Inner Hypoxia Stress

(2022) Xiao Liu et al.   Genes

A circuit from lateral septum neurotensin neurons to tuberal nucleus controls hedonic feeding

(2022) Zijun Chen et al.   MOLECULAR PSYCHIATRY

The role of GABA in islet function

(2022) D. Walker Hagan et al.   Frontiers in Endocrinology

The effect of gamma-aminobutyric acid supplementation on growth performances, immune responses, and blood parameters of chickens reared under stressful environment: a meta-analysis

(2021) Chris Major Ncho et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans

(2021) Zhongfan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrasonication increases γ‐aminobutyric acid accumulation in coffee leaves and affects total phenolic content and angiotensin‐converting enzyme inhibitory activity

(2021) Dayi Ji et al.   JOURNAL OF FOOD PROCESSING AND PRESERVATION

United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)

(2021) Hellen A. Oketch-Rabah et al.   Nutrients

Synergistic effect of Korean red ginseng extract and GABA mixture on the IgE production in mice via Th1/Th2 cell balance

(2021) Jung Sik Lim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Characterization of a novel glutamate decarboxylase (GAD) from Latilactobacillus curvatus K285 isolated from Gat -Kimchi

(2021) Se Jin Lee et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Optimal soaking conditions and addition of exogenous substances improve accumulation of γ‐aminobutyric acid (GABA) in germinated mung bean ( Vigna radiata )

(2021) Nguyen Thi Hoang Yen et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

An Overview of Bioprocesses Employing Specifically Selected Microbial Catalysts for γ-Aminobutyric Acid Production

(2021) Divakar Dahiya et al.   Microorganisms

Biofortification of Cereals and Pulses Using New Breeding Techniques: Current and Future Perspectives

(2021) Rahil Shahzad et al.   Frontiers in Nutrition

Improving the Thermostability of Glutamate Decarboxylase from Lactobacillus brevis by Consensus Mutagenesis

(2020) Yujiao Hua et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Induction of γ‐aminobutyric acid plays a positive role to Arabidopsis resistance against Pseudomonas syringae

(2020) Xiangxiong Deng et al.   Journal of Integrative Plant Biology

Gamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism

(2020) Xiaolei Wu et al.   BMC PLANT BIOLOGY

Challenges and Prospects of New Plant Breeding Techniques for GABA Improvement in Crops: Tomato as an Example

(2020) Pietro Gramazio et al.   Frontiers in Plant Science

γ-Aminobutyric Acid Suppresses Iron Transportation from Roots to Shoots in Rice Seedlings by Inducing Aerenchyma Formation

(2020) Changhua Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diverse role of γ-aminobutyric acid in dynamic plant cell responses

(2019) Maryam Seifikalhor et al.   PLANT CELL REPORTS

Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity

(2019) Chiayu Q. Chiu et al.   NATURE REVIEWS NEUROSCIENCE

An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid

(2019) Dai-Hung Ngo et al.   MOLECULES

GABA (γ-aminobutyric acid), as a thermo-protectant, to improve the reproductive function of heat-stressed mungbean plants

(2019) Manu Priya et al.   Scientific Reports

GABA negatively regulates adventitious root development

(2019) Tiantian Xie et al.   JOURNAL OF EXPERIMENTAL BOTANY

Cytosolic GABA inhibits anion transport by wheat ALMT1

(2019) Yu Long et al.   NEW PHYTOLOGIST

A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes

(2019) Sabna B. Sarasa et al.   CURRENT MICROBIOLOGY

Use of Streptococcus thermophilus for the in situ production of γ-aminobutyric acid-enriched fermented milk

(2019) Mei Han et al.   JOURNAL OF DAIRY SCIENCE

Accumulating pathways of γ-aminobutyric acid during anaerobic and aerobic sequential incubations in fresh tea leaves

(2018) Qin Yan Wu et al.   FOOD CHEMISTRY

Effects of controlled germination on selected physicochemical and functional properties of whole-wheat flour and enhanced γ-aminobutyric acid accumulation by ultrasonication

(2018) Junzhou Ding et al.   FOOD CHEMISTRY

Relationship of executive functioning deficits to N-acetyl aspartate (NAA) and gamma-aminobutyric acid (GABA) in youth with bipolar disorder

(2018) Rebekah S. Huber et al.   JOURNAL OF AFFECTIVE DISORDERS

Antihypertensive Effect of γ-Aminobutyric Acid-Enriched Brown Rice on Spontaneously Hypertensive Rats

(2018) Kohei KAWAKAMI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Gut Microbiota and the Neuroendocrine System

(2018) Aitak Farzi et al.   Neurotherapeutics

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes

(2018) Amol K. Bhandage et al.   EBioMedicine

A review on coffee leaves: Phytochemicals, bioactivities and applications

(2018) Xiumin Chen   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Enhanced accumulation of gamma-aminobutyric acid in rice bran using anaerobic incubation with various additives

(2018) Su-Jin Oh et al.   FOOD CHEMISTRY

Consumption of Salted Pickles of Sun-dried Radish Roots (Raphanus sativus cv. YR-Hyuga-Risou) Attenuates Blood Pressure in Spontaneously Hypertensive Rats

(2017) Kotaro Tashiro et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Multiplexed CRISPR/Cas9-mediated metabolic engineering of γ-aminobutyric acid levels in Solanum lycopersicum

(2017) Rui Li et al.   PLANT BIOTECHNOLOGY JOURNAL

Transaminase encoded by NCgl2515 gene of Corynebacterium glutamicum ATCC13032 is involved in γ-aminobutyric acid decomposition

(2017) Feng Shi et al.   PROCESS BIOCHEMISTRY

Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

(2017) Asad Ullah et al.   Journal of Ovarian Research

γ-Aminobutyric acid (GABA) signalling in plants

(2016) Sunita A. Ramesh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Methyl-inositol,γ-aminobutyric acid and other health benefit compounds in the aril of litchi

(2016) Zi-Chen Wu et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Impact of Precooling and Controlled-Atmosphere Storage on γ-Aminobutyric Acid (GABA) Accumulation in Longan (Dimocarpus longan Lour.) Fruit

(2016) Molin Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Activating glutamate decarboxylase activity by removing the autoinhibitory domain leads to hyper γ-aminobutyric acid (GABA) accumulation in tomato fruit

(2016) Mariko Takayama et al.   PLANT CELL REPORTS

Plant GABA: Not Just a Metabolite

(2016) Alan W. Bown et al.   TRENDS IN PLANT SCIENCE

The GABA Transaminase, ABAT, Is Essential for Mitochondrial Nucleoside Metabolism

(2015) Arnaud Besse et al.   Cell Metabolism

The ultrasound-treated soybean seeds improve edibility and nutritional quality of soybean sprouts

(2015) Hui Yang et al.   FOOD RESEARCH INTERNATIONAL

The protective effect of γ-aminobutyric acid on the development of immune function in chickens under heat stress

(2015) J. Tang et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Systemic cytosolic Ca2+elevation is activated upon wounding and herbivory in Arabidopsis

(2015) Victoria Kiep et al.   NEW PHYTOLOGIST

Tomato Glutamate Decarboxylase GenesSlGAD2andSlGAD3Play Key Roles in Regulating γ-Aminobutyric Acid Levels in Tomato (Solanum lycopersicum)

(2015) Mariko Takayama et al.   PLANT AND CELL PHYSIOLOGY

Combined Therapy With GABA and Proinsulin/Alum Acts Synergistically to Restore Long-term Normoglycemia by Modulating T-Cell Autoimmunity and Promoting  -Cell Replication in Newly Diabetic NOD Mice

(2014) J. Tian et al.   DIABETES

Production of γ-aminobutyric acid during fermentation of Gastrodia elata Bl. by co-culture of Lactobacillus brevis GABA 100 with Bifidobacterium bifidum BGN4

(2014) Jeong Ah Kim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Combined Transcriptomics and Metabolomics of Arabidopsis thaliana Seedlings Exposed to Exogenous GABA Suggest Its Role in Plants Is Predominantly Metabolic

(2014) Albert Batushansky et al.   Molecular Plant

Germinated brown rice regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats

(2014) Mustapha Umar Imam et al.   Journal of Functional Foods

gadAgene locus inLactobacillus brevisNCL912 and its expression during fed-batch fermentation

(2013) Haixing Li et al.   FEMS MICROBIOLOGY LETTERS

The endogenous GABA bioactivity of camel, bovine, goat and human milks

(2013) Agenor Limon et al.   FOOD CHEMISTRY

Utilization of Barley or Wheat Bran to Bioconvert Glutamate to γ-Aminobutyric Acid (GABA)

(2013) Wen-Jie Jin et al.   JOURNAL OF FOOD SCIENCE

Role of GABAergic activity of sodium valproate against ischemia–reperfusion-induced acute kidney injury in rats

(2013) Ramanpreet Brar et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Genetic manipulation of the γ-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of γ-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kern

(2013) Yasuka Shimajiri et al.   PLANT BIOTECHNOLOGY JOURNAL

γ-Aminobutyric acid (GABA) homeostasis regulates pollen germination and polarized growth in Picea wilsonii

(2013) Yu Ling et al.   PLANTA

Influence of preprocessing methods and fermentation of adzuki beans on γ-aminobutyric acid (GABA) accumulation by lactic acid bacteria

(2013) Wan-Chung Liao et al.   Journal of Functional Foods

Benefit of Monascus-fermented products for hypertension prevention: a review

(2012) Bao-Hong Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Strategies and tools for studying the metabolism and function of γ-aminobutyrate in plants. I. Pathway structure

(2012) Barry J. Shelp et al.   Botany

Salt Stress Induces Accumulation of γ–Aminobutyric Acid in Germinated Foxtail Millet (Setaria italicaL.)

(2012) Qingyun Bai et al.   CEREAL CHEMISTRY

Effect of Timing and Duration of Salt Treatment during Growth of a Fragrant Rice Variety on Yield and 2-Acetyl-1-pyrroline, Proline, and GABA Levels

(2012) Janchai Poonlaphdecha et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia

(2012) Shin-Yu Chen et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Direct and glia-mediated effects of GABA on development of central olfactory neurons

(2012) Heather S. Mallory et al.   Neuron Glia Biology

Hypothesis/review: Contribution of putrescine to 4-aminobutyrate (GABA) production in response to abiotic stress

(2012) Barry J. Shelp et al.   PLANT SCIENCE

Effects of soaking and aeration treatment on γ-aminobutyric acid accumulation in germinated soybean (Glycine max L.)

(2011) Yuanxin Guo et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

In situ production of γ-aminobutyric acid in breakfast cereals

(2011) Iris J. Joye et al.   FOOD CHEMISTRY

Sequential hydration with anaerobic and heat treatment increases GABA (γ-aminobutyric acid) content in wheat

(2011) Young-Su Youn et al.   FOOD CHEMISTRY

Antihypertensive effect of mulberry leaf aqueous extract containing γ-aminobutyric acid in spontaneously hypertensive rats

(2011) Nae-Cherng Yang et al.   FOOD CHEMISTRY

Antihypertensive Effects of Lactobacillus-Fermented Milk Orally Administered to Spontaneously Hypertensive Rats

(2011) Chin Feng Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Production of GABA-Enriched Powder by a Brown Variety of Flammulina velutipes (Enokitake) and Its Antihypertensive Effects in Spontaneously Hypertensive Rats

(2011) Akira Harada et al.   JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI

GABA Accumulation Causes Cell Elongation Defects and a Decrease in Expression of Genes Encoding Secreted and Cell Wall-Related Proteins in Arabidopsis thaliana

(2011) Hugues Renault et al.   PLANT AND CELL PHYSIOLOGY

A mitochondrial GABA permease connects the GABA shunt and the TCA cycle, and is essential for normal carbon metabolism

(2011) Simon Michaeli et al.   PLANT JOURNAL

Rapid automated high performance liquid chromatography method for simultaneous determination of amino acids and biogenic amines in wine, fruit and honey

(2010) Mary T. Kelly et al.   JOURNAL OF CHROMATOGRAPHY A

γ-Aminobutyric acid (GABA) accumulation in four strawberry cultivars in response to elevated CO2 storage

(2010) Rujira Deewatthanawong et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

Inhibitory role for GABA in autoimmune inflammation

(2010) R. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Reveals YihU as a Novel Hydroxybutyrate Dehydrogenase for Alternative Succinic Semialdehyde Metabolism inEscherichia coli

(2009) Natsumi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers

(2009) Hiroko Tanaka et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Defining the role of GABA in cortical development

(2009) Doris D. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of steeping and anaerobic treatment on GABA (γ-aminobutyric acid) content in germinated waxy hull-less barley

(2009) Hyun-Jung Chung et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Effects of culture conditions on γ-aminobutyric acid accumulation during germination of foxtail millet (Setaria italica L.)

(2008) Qingyun Bai et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation

(2008) Michael Andäng et al.   NATURE

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Biochemical Mechanism on GABA Accumulation During Fruit Development in Tomato

(2008) Takashi Akihiro et al.   PLANT AND CELL PHYSIOLOGY

Mutants of GABA Transaminase (POP2) Suppress the Severe Phenotype of succinic semialdehyde dehydrogenase (ssadh) Mutants in Arabidopsis

(2008) Frank Ludewig et al.   PLoS One

Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana

(2007) Y. Miyashita et al.   PLANT AND CELL PHYSIOLOGY

Treatment of Germinated Wheat to Increase Levels of GABA and IP6 Catalyzed by Endogenous Enzymes

(2005) Hiroyuki Nagaoka   BIOTECHNOLOGY PROGRESS