The GPCR properties of polycystin-1- A new paradigm

Ligands and Beyond: Mechanosensitive Adhesion GPCRs

(2022) Hsi-Hsien Lin et al.   Pharmaceuticals

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Adhesion G Protein-Coupled Receptors: Structure, Signaling, Physiology and Pathophysiology

(2022) Randy A. Hall et al.   PHYSIOLOGICAL REVIEWS

Mechanism of tethered agonist-mediated signaling by polycystin-1

(2022) Shristi Pawnikar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

(2022) Charles E MacKay et al.   eLife

Monoallelic pathogenic ALG5 variants cause atypical polycystic kidney disease and interstitial fibrosis

(2022) Hugo Lemoine et al.   AMERICAN JOURNAL OF HUMAN GENETICS

G Protein‐Coupled Receptor Signaling: Transducers and Effectors

(2022) Haoran Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adhesion G protein-coupled receptor gluing action guides tissue development and disease

(2022) Abhijit Sreepada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression

(2022) Ronak Lakhia et al.   Nature Communications

The N Terminus of Adhesion G Protein–Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator

(2022) Jakob Mitgau et al.   Frontiers in Cell and Developmental Biology

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

(2021) Deva Krupakar Kusuluri et al.   iScience

Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling

(2021) Joshua D. Frenster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype

(2021) Sarah R. Senum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Renal plasticity revealed through reversal of polycystic kidney disease in mice

(2021) Ke Dong et al.   NATURE GENETICS

Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

(2020) Nisha Bhudia et al.   Scientific Reports

Analysis of the polycystin complex (PCC) in human urinary exosome–like vesicles (ELVs)

(2020) Wendy A. Lea et al.   Scientific Reports

CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2

(2020) Andrea N. Naranjo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

(2020) Jingxian Li et al.   Nature Communications

Regulation of polycystin expression, maturation and trafficking

(2020) Jinghua Hu et al.   CELLULAR SIGNALLING

Polycystins as components of large multiprotein complexes of polycystin interactors

(2020) Emily Hardy et al.   CELLULAR SIGNALLING

Adhesion GPCRs as a paradigm for understanding polycystin-1 G protein regulation

(2020) Robin L. Maser et al.   CELLULAR SIGNALLING

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

(2020) Jennifer Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agonist-induced formation of unproductive receptor-G12complexes

(2020) Najeah Okashah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126)

(2020) Enric Lizano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

(2019) Richard Sando et al.   SCIENCE

A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site

(2019) Parul Kashyap et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Protein phosphatase 1α interacts with a novel ciliary targeting sequence of polycystin-1 and regulates polycystin-1 trafficking

(2019) Chong Luo et al.   FASEB JOURNAL

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex

(2019) Zhifei Wang et al.   EMBO REPORTS

ALG9 Mutation Carriers Develop Kidney and Liver Cysts

(2019) Whitney Besse et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Beyond the Ligand: Extracellular and Transcellular G Protein–Coupled Receptor Complexes in Physiology and Pharmacology

(2019) Henry A. Dunn et al.   PHARMACOLOGICAL REVIEWS

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease

(2019) Edmund C. Lee et al.   Nature Communications

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

(2019) Elisa Agnese Nigro et al.   Scientific Reports

Divergent function of polycystin 1 and polycystin 2 in cell size regulation

(2019) Amandine Viau et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease

(2018) Emilie Cornec-Le Gall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney

(2018) Bo Zhang et al.   DEVELOPMENT

A Mutation Affecting Polycystin-1 Mediated Heterotrimeric G-Protein Signaling Causes PKD

(2018) Stephen C Parnell et al.   HUMAN MOLECULAR GENETICS

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation

(2018) Misun Kwak et al.   Scientific Reports

A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed

(2018) Cheng-Chao Lin et al.   Scientific Reports

Structure of the human PKD1-PKD2 complex

(2018) Qiang Su et al.   SCIENCE

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

(2018) Raimunda S. S. Azevedo et al.   Scientific Reports

Isolated polycystic liver disease genes define effectors of polycystin-1 function

(2017) Whitney Besse et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases

(2017) Emilie Cornec-Le Gall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

(2017) Gabriel S. Salzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two views of the same stimulus

(2017) Wayne A Johnson   eLife

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord

(2016) Yanina L. Petracca et al.   DEVELOPMENT

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Gα12 is required for renal cystogenesis induced byPkd1inactivation

(2016) Yong Wu et al.   JOURNAL OF CELL SCIENCE

The polycystin complex mediates Wnt/Ca2+ signalling

(2016) Seokho Kim et al.   NATURE CELL BIOLOGY

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

Regulation of Polycystin-1 Function by Calmodulin Binding

(2016) Nicholas Doerr et al.   PLoS One

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

(2015) Maddalena Castelli et al.   BMC CELL BIOLOGY

Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site

(2015) X. Su et al.   JOURNAL OF CELL SCIENCE

Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity

(2015) Sorin V. Fedeles et al.   JOURNAL OF CLINICAL INVESTIGATION

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner

(2015) Vladimir G. Gainullin et al.   JOURNAL OF CLINICAL INVESTIGATION

The Polycystin-1, Lipoxygenase, and  -Toxin Domain Regulates Polycystin-1 Trafficking

(2015) Y. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells

(2015) Jen X. Xu et al.   PHYSIOLOGICAL GENOMICS

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

(2015) Elisa Nigro et al.   Cells

Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex

(2014) G. Yao et al.   HUMAN MOLECULAR GENETICS

Altered trafficking and stability of polycystins underlie polycystic kidney disease

(2014) Yiqiang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

(2014) A. Kurbegovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

(2014) Hyunho Kim et al.   Nature Communications

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Direct recording and molecular identification of the calcium channel of primary cilia

(2013) Paul G. DeCaen et al.   NATURE

Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins

(2013) Simone Prömel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

(2013) Maddalena Castelli et al.   Nature Communications

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Autosomal dominant polycystic kidney disease: Comprehensive mutation analysis of PKD1 and PKD2 in 700 unrelated patients

(2012) Marie-Pierre Audrézet et al.   HUMAN MUTATION

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Gene Mutations in Autosomal Dominant Polycystic Kidney Disease through Targeted Resequencing

(2012) S. Rossetti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protein Phosphatase-1α Interacts with and Dephosphorylates Polycystin-1

(2012) Stephen C. Parnell et al.   PLoS One

G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease

(2012) M. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex

(2012) Yong Yu et al.   Nature Communications

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

(2011) S. Field et al.   DEVELOPMENT

Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis

(2011) K. Kamura et al.   DEVELOPMENT

Cell Adhesion Receptor GPR133 Couples to GsProtein

(2011) Jens Bohnekamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

(2011) Heather H. Ward et al.   MOLECULAR BIOLOGY OF THE CELL

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

(2011) Sorin V Fedeles et al.   NATURE GENETICS

Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach

(2011) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystin-1 regulates STAT activity by a dual mechanism

(2011) J. J. Talbot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis

(2010) Wanfeng Yu et al.   CELLULAR SIGNALLING

Polycystin-1 Protein Level Determines Activity of the Gα12/JNK Apoptosis Pathway

(2010) Wanfeng Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Occurring Osmolytes Modulate the Nanomechanical Properties of Polycystic Kidney Disease Domains

(2010) Liang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site

(2010) Hannah C. Chapin et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca2+ Entry through Interactions with STIM1

(2010) Owen M. Woodward et al.   PLoS One

Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains

(2009) Liang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

(2009) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presence of De Novo Mutations in Autosomal Dominant Polycystic Kidney Disease Patients Without Family History

(2008) Berenice Reed et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1

(2008) Surya M. Nauli et al.   CIRCULATION

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

(2008) Mark Lal et al.   HUMAN MOLECULAR GENETICS

Novel method for genomic analysis ofPKD1andPKD2mutations in autosomal dominant polycystic kidney disease

(2008) Ying-Cai Tan et al.   HUMAN MUTATION