Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway

(2018) Dechao Xu et al.   FASEB JOURNAL

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

(2018) Jing Cai et al.   GENES & DEVELOPMENT

A Mutation Affecting Polycystin-1 Mediated Heterotrimeric G-Protein Signaling Causes PKD

(2018) Stephen C Parnell et al.   HUMAN MOLECULAR GENETICS

Biomechanics and mechanical signaling in the ovary: a systematic review

(2018) Jaimin S. Shah et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Polycystin-1 regulates bone development through an interaction with the transcriptional co-activator taz

(2018) David Merrick et al.   HUMAN MOLECULAR GENETICS

Polycystins in disease mechanobiology

(2018) Antonios N. Gargalionis et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis

(2017) Zhousheng Xiao et al.   JOURNAL OF CLINICAL INVESTIGATION

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Polycystins and intercellular mechanotransduction: A precise dosage of polycystin 2 is necessary for alpha-actinin reinforcement of junctions upon mechanical stimulation

(2016) Laxsoomee Bhoonderowa et al.   EXPERIMENTAL CELL RESEARCH

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation

(2016) Valentina Grampa et al.   PLoS Genetics

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

(2015) Maddalena Castelli et al.   BMC CELL BIOLOGY

Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability

(2015) Z. Pedrozo et al.   CIRCULATION

2-Deoxy-D-Glucose Ameliorates PKD Progression

(2015) M. Chiaravalli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A polycystin-centric view of cyst formation and disease: the polycystins revisited

(2015) Albert C.M. Ong et al.   KIDNEY INTERNATIONAL

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

(2015) Elisa Nigro et al.   Cells

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures

(2014) Isaline Rowe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex

(2014) G. Yao et al.   HUMAN MOLECULAR GENETICS

Inactivation of Integrin- 1 Prevents the Development of Polycystic Kidney Disease after the Loss of Polycystin-1

(2014) K. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

(2014) Patricia Outeda et al.   Cell Reports

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

(2013) Maddalena Castelli et al.   Nature Communications

Altered Hippo signalling in polycystic kidney disease

(2011) Hester Happé et al.   JOURNAL OF PATHOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Myosin light chain kinase in microvascular endothelial barrier function

(2010) Q. Shen et al.   CARDIOVASCULAR RESEARCH

The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation

(2010) S. Mangos et al.   Disease Models & Mechanisms

The cell biology of polycystic kidney disease

(2010) Hannah C. Chapin et al.   JOURNAL OF CELL BIOLOGY

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

(2009) Claas Wodarczyk et al.   PLoS One

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY