A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126)

Activation of the GLP-1 receptor by a non-peptidic agonist

(2020) Peishen Zhao et al.   NATURE

Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

(2020) Reid H. J. Olsen et al.   Nature Chemical Biology

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

(2020) Francis S. Willard et al.   JCI Insight

Synthetic protease-activated class B GPCRs

(2020) Francis S. Willard et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel approaches leading towards peptide GPCR de‐orphanisation

(2019) Alexander S. Hauser et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agonist-bound structure of the human P2Y12 receptor

(2014) Jin Zhang et al.   NATURE

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor

(2012) Francis S. Willard et al.   Experimental Diabetes Research

A Luminescent Biosensor with Increased Dynamic Range for Intracellular cAMP

(2011) Brock F. Binkowski et al.   ACS Chemical Biology

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

(2011) Kevin J. Paavola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Point Mutation to GαiSelectively Blocks GoLoco Motif Binding

(2008) Francis S. Willard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY