Article
Cell Biology
Xianghui Kong, Xinliang Lu, Shibo Wang, Jiayue Hao, Danfeng Guo, Hao Wu, Yu Jiang, Yi Sun, Jianli Wang, Gensheng Zhang, Zhijian Cai
Summary: This study reveals that deficiency of UBE2M in macrophages leads to decreased expression of IFN-I in response to RNA virus infection, resulting in aggravated viral infection. Additionally, the study shows that administration of milk-derived extracellular vesicles containing TRIM21-DRING enhances antiviral immunity in macrophages. These findings uncover a negative feedback loop of IFN-I signaling and offer a reagent to improve innate immunity against RNA viruses.
Article
Biochemistry & Molecular Biology
Yue Zhang, Yuxuan Song, Shuang Ren, Minqin Zhang, Zhao Zhang, Shuangqin Fan, Xing Liu, Xiaoyu Peng, Qi Qi, Xiangchun Shen, Yan Chen
Summary: The GPER/HIF-1α axis plays a critical role in promoting aerobic glycolysis in tamoxifen-resistant cells.
Article
Medicine, Research & Experimental
Tolani F. Olonisakin, Tomeka Suber, Shekina Gonzalez-Ferrer, Zeyu Xiong, Hernan F. Penaloza, Rick van der Geest, Yuting Xiong, David O. Osei-Hwedieh, Jesus Tejero, Matthew R. Rosengart, Wendy M. Mars, Daria Van Tyne, Andreas Perlegas, Samuel Brashears, Daniel B. Kim-Shapiro, Mark T. Gladwin, Michael A. Bachman, Eldad A. Hod, Claudette St Croix, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli, Anuradha Ray, Prabir Ray, Janet S. Lee
Summary: Macrophages play a crucial role in heme metabolism and immune defense, but excessive heme can lead to immunosuppression. The clearance of senescent RBCs by macrophages impairs immunity and is independent of bacterial iron acquisition.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Jun Yuan, Xiaomei He, Yinsheng Wang
Summary: High-order chromatin organization is crucial for biological processes and disease development. This study investigated the role of guanine quadruplex (G4) structures in RNA polymerase II (RNAPII)-mediated DNA interactions and transcription activity. Data analysis revealed a strong positive correlation between RNAPII-linked DNA loops and G4 structures in chromatin. Treatment with PDS, a G4-binding ligand, was found to diminish RNAPII-linked long-range DNA contacts, especially those involving G4 structure loci, leading to changes in gene expression.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Nanfang Huang, Yang Song, Wenhui Shi, Juan Guo, Lingyun Wu, Zheng Zhang, Qi He, Xiao Li, Feng Xu
Summary: DHX9 overexpression in myelodysplastic syndromes (MDS) is associated with poor prognosis and high risk of acute myeloid leukemia (AML) transformation. DHX9 is essential for malignant proliferation of leukemia cells. Suppression of DHX9 increases cell apoptosis and sensitizes cells to chemotherapy. Additionally, DHX9 knockdown inactivates PI3K-AKT and ATR-Chk1 signaling, promotes R-loop accumulation, and leads to R-loop-mediated DNA damage.
Article
Cell Biology
Wei Chen, Yilong Wang, Wenwen Xia, Jinbao Zhang, Yan Zhao
Summary: This study describes the role of RNA binding protein hnRNPA2B1 in the development of hypertriglyceridemia-induced acute pancreatitis (HTGP). The results show that the level of hnRNPA2B1 protein decreases in PA-treated cells and its expression is regulated by neddylation. hnRNPA2B1 orchestrates fatty acid oxidation by regulating the expression of mitochondrial trifunctional protein-alpha (MTP alpha). Restoration of hnRNPA2B1 expression using the neddylation inhibitor MLN4924 can protect cells from PA-induced inflammatory injury. In vivo administration of MLN4924 restores hnRNPA2B1 protein expression in the pancreas and ameliorates HTGP-associated inflammation and tissue injury.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Hainan Liu, Yan Cui, Yu Bai, Yi Fang, Ting Gao, Guangfei Wang, Lin Zhu, Qincai Dong, Shuwei Zhang, Yi Yao, Caiwei Song, Xiayang Niu, Yanwen Jin, Ping Li, Cheng Cao, Xuan Liu
Summary: The study demonstrates that c-Abl and Arg kinases interact with STAT1, enhancing its phosphorylation and regulating antiviral immune responses, indicating the essential role of c-Abl in antiviral immunity.
Article
Multidisciplinary Sciences
Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Summary: The study revealed that STAT1 plays a crucial role in maintaining the quiescence of naive CD8(+) T cells, with its deficiency leading to increased proliferation and abnormal expansion of memory/activated cells. This phenomenon is paradoxically dependent on type I interferon and its alternative signaling pathway.
Review
Biochemistry & Molecular Biology
Ying Liu, Xiaoyun Wang, Danhui Dong, Luqin Guo, Xiaonan Dong, Jing Leng, Bing Zhao, Yang-Dong Guo, Na Zhang
Summary: G-proteins and GPCRs, as crucial signal transducers in signal transduction, have attracted increasing attention in both animal and plant research. The mode of action of G-proteins differs significantly between animals and plants, with plants possessing self-activated G alpha subunits and unique GPCR functions. More research is needed to understand the regulatory mechanisms and roles of uncanonical GPCRs in plant stress resistance and agricultural production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kazuhisa Kinoshita, Yuko Tsubota, Shoji Tane, Yuuki Aizawa, Ryota Sakata, Kozo Takeuchi, Keishi Shintomi, Tomoko Nishiyama, Tatsuya Hirano
Summary: The study investigates the role of condensin I in chromosome assembly and identifies two classes of mutations that cause abnormal chromosome compaction. The findings reveal the involvement of a mechanism independent of loop extrusion in condensin I-mediated chromosome assembly and shaping.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Oncology
Andrea P. Cabrera, Jonathan Stoddard, Irene Santiago Tierno, Nikolaos Matisioudis, Mahesh Agarwal, Lauren Renner, Neha Palegar, Martha Neuringer, Trevor McGill, Kaustabh Ghosh
Summary: The study found differences in the characteristics of choroidal endothelial cells in young and old monkey eyes, with cells in older eyes being stiffer and more susceptible to complement activation-induced damage. These differences may be related to the activities of the mechanical structure regulators Rac and Rho in the cells. These findings offer new mechanistic insights into choroidal vascular loss in early AMD and warrant further investigation for translational potential.
JOURNAL OF PATHOLOGY
(2022)
Article
Peripheral Vascular Disease
Yusi Wu, Bingjie Pan, Zhen Zhang, Xiaohui Li, Yiping Leng, Yong Ji, Kun Sun, Alex F. Chen
Summary: The study reveals the critical role of caspase-4/11 in the pyroptosis pathway, which regulates pulmonary vascular dysfunction and accelerates the progression of pulmonary arterial hypertension (PAH). These findings provide a potential target for the diagnosis and treatment of PAH.
Article
Pharmacology & Pharmacy
Shuai Chen, Keyu Lv, Anish Sharda, Jun Deng, Wanjiang Zeng, Chao Zhang, Qinghua Hu, Pengfei Jin, Guangmin Yao, Xulin Xu, Zhangyin Ming, Chao Fang
Summary: DHM demonstrates potent antithrombotic effects by inhibiting platelet and endothelial cell activation, delaying thrombosis formation, and reducing fibrin generation without causing bleeding. Its mechanisms of action involve suppressing thrombin-induced calcium mobilization and MAPK activation, protecting endothelial cells, and decreasing fibrin production.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Physiology
Junfei Cheng, Yuemei Sun, Jiaxin He, Zihan Wang, Wenbin Li, Rong Wang
Summary: The high-altitude environment damages the intestinal mucosal barrier and leads to a high incidence of intestinal diseases, but the mechanism is not well defined. This study found that high altitude causes inflammatory damage to colon tissue and exacerbates intestinal hypoxia. The results highlight that the high-altitude environment reduces the concentration of oxygen in the colonic lumen microenvironment, disrupts the colonic mucosal barrier, and ultimately induces and exacerbates intestinal injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zechuan Zhang, Zetao Ji, Jianbo He, Yijun Lu, Wenfang Tian, Chang Zheng, Huihui Chen, Quan Zhang, Fei Yang, Minglu Zhang, Yin Yin, Runqiu Jiang, Wen-Ming Chu, Wenjie Zhang, Beicheng Sun
Summary: The study found that GNAI2 is significantly up-regulated in liver tissues of NASH patients, and Gnai2-deficient mice showed reduced steatohepatitis symptoms under dietary conditions, indicating the important role of GNAI2 in the development of NASH.
Article
Neurosciences
Sang Eun Park, Ji Hoon Song, Chansik Hong, Dong Eun Kim, Jee-Won Sul, Tae-Youn Kim, Bo-Ra Seo, Insuk So, Sang-Yeob Kim, Dong-Jun Bae, Mi-Ha Park, Hye Min Lim, In-Jeoung Baek, Antonio Riccio, Joo-Yong Lee, Woo Hyun Shim, Bumwoo Park, Jae-Young Koh, Jung Jin Hwang
MOLECULAR NEUROBIOLOGY
(2019)
Correction
Neurosciences
Sang Eun Park, Ji Hoon Song, Chansik Hong, Dong Eun Kim, Jee-Won Sul, Tae-Youn Kim, Bo-Ra Seo, Insuk So, Sang-Yeob Kim, Dong-Jun Bae, Mi-Ha Park, Hye Min Lim, In-Jeoung Baek, Antonio Riccio, Joo-Yong Lee, Woo Hyun Shim, Bumwoo Park, Jae-Young Koh, Jung Jin Hwang
MOLECULAR NEUROBIOLOGY
(2019)
Review
Physiology
Jinsung Kim, Juyeon Ko, Jongyun Myeong, Misun Kwak, Chansik Hong, Insuk So
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Chansik Hong, Seo Hwa Choi, Misun Kwak, Byeongseok Jeong, Juyeon Ko, Hyung Joon Park, Seok Choi, Jae Yeoul Jun, Insuk So
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Jung Nyeo Chun, Minsoo Cho, Soonbum Park, Insuk So, Ju-Hong Jeon
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2020)
Article
Oncology
Soonbum Park, Jin-Muk Lim, Jung Nyeo Chun, Sanghoon Lee, Tae Min Kim, Dong-Wan Kim, Sang-Yeob Kim, Dong-Jun Bae, Sang-Mun Bae, Insuk So, Hong-Gee Kim, Ji-Yeob Choi, Ju-Hong Jeon
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Review
Cell Biology
Jinsung Kim, Juyeon Ko, Chansik Hong, Insuk So
Review
Physiology
Chansik Hong, Byeongseok Jeong, Hyung Joon Park, Ji Yeon Chung, Jung Eun Lee, Jinsung Kim, Young-Cheul Shin, Insuk So
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Hyo-Jun Kim, Jin-Haeng Lee, Sung-Yup Cho, Ju-Hong Jeon, In-Gyu Kim
Summary: The study reveals that TG2 interacts with BAF250a and mediates its polyamination, thereby regulating transcriptional activity.
Article
Biology
Sanghoon Lee, Jung Nyeo Chun, Hae-Jeung Lee, Hyun Ho Park, Insuk So, Ju-Hong Jeon, Eun-Jung Park
Summary: This study found that SCE and SchB can reverse the gene expression profile changes induced by TGF beta in VSMCs, inhibiting fibrosis-associated biological processes such as inflammation, cell proliferation, and migration. Master regulator analysis identified crucial transcription factors that regulate the expression of genes affected by SCE and SchB, providing insight into the pharmacological action of these compounds at the transcriptome level for potential treatment of vascular fibrosis.
Article
Cell Biology
Seok Choi, Hyunhyo Seo, Kyungmin Lee, Dong Hoon Shin, Mei Jin Wu, Wenhao Wu, Xingyou Huang, Jingwei Zhang, Chansik Hong, Jae Yeoul Jun
Summary: The study revealed the presence of HCN channels in colonic ICC and their involvement in generating pacemaking potentials, suggesting that HCN channels could be therapeutic targets for disturbed colonic motility disorders.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Byeongseok Jeong, Tae Sik Sung, Dongju Jeon, Kyu Joo Park, Jae Yeoul Jun, Insuk So, Chansik Hong
Summary: This study investigated the molecular mechanism of tricyclic antidepressants (TCAs) in the gastrointestinal (GI) tract. The findings suggest that TCAs inhibit the TRPC4 channels in colonic myocytes, ultimately leading to constipation. These findings provide clinical insights into abnormal intestinal motility and IBS therapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Jinsung Kim, Sang Hui Moon, Taewook Kim, Juyeon Ko, Young Keul Jeon, Young-Cheul Shin, Ju-Hong Jeon, Insuk So
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Juyeon Ko, Jongyun Myeong, Misun Kwak, Ju-Hong Jeon, Insuk So
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
SeungJoo Jeong, Juyeon Ko, Minji Kim, Ki Chul Park, Eunice Yon June Park, Jinsung Kim, Youngjoo Baik, Jinhong Wie, Art E. Cho, Ju-hong Jeon, Insuk So
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2019)