Adhesion G protein-coupled receptor gluing action guides tissue development and disease

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells

(2021) Robert J. Hall et al.   FASEB JOURNAL

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

(2021) Anastasia Georgiadi et al.   Nature Communications

Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development

(2021) Rebeca Torregrosa-Carrión et al.   Science Advances

The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance

(2020) Tomáš Suchý et al.   INTERNATIONAL JOURNAL OF OBESITY

Mechanisms of heart valve development and disease

(2020) Anna O'Donnell et al.   DEVELOPMENT

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

Single-Cell RNA-seq Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells

(2020) David T. Paik et al.   CIRCULATION

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

(2020) Jennifer Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion

(2020) Nathan A. Zaidman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126)

(2020) Enric Lizano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

(2020) Yujing Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder

(2019) Djenifer B. Kappel et al.   NEUROMOLECULAR MEDICINE

High GPR56 surface expression correlates with a leukemic stem cell gene signature in CD34-positive AML

(2019) Shruti Daga et al.   Cancer Medicine

Adhesion G-protein coupled receptors: Implications for metabolic function

(2019) Oladapo E. Olaniru et al.   PHARMACOLOGY & THERAPEUTICS

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

(2019) Phuwanat Sakornsakolpat et al.   NATURE GENETICS

Revisiting the classification of adhesion GPCRs

(2019) Nicole Scholz et al.   Annals of the New York Academy of Sciences

The Role of the Extracellular Matrix in Cancer Stemness

(2019) Sameera Nallanthighal et al.   Frontiers in Cell and Developmental Biology

In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development

(2019) Ethan C. Bradley et al.   Annals of the New York Academy of Sciences

ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis

(2019) Junjun Li et al.   Scientific Reports

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

(2018) Oladapo E. Olaniru et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Planar cell polarity in organ formation

(2018) Deborah J Henderson et al.   CURRENT OPINION IN CELL BIOLOGY

The role of ADHD associated genes in neurodevelopment

(2018) Callum Dark et al.   DEVELOPMENTAL BIOLOGY

Artemin regulates CXCR4 expression to induce migration and invasion in pancreatic cancer cells through activation of NF-κB signaling

(2018) Juan Wang et al.   EXPERIMENTAL CELL RESEARCH

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin

(2018) Sarah D. Ackerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci

(2018) Anas M Khanshour et al.   HUMAN MOLECULAR GENETICS

Complement 1q like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein–coupled receptor BAI3

(2018) Rajesh Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

(2018) Ikuyo Kou et al.   Scientific Reports

LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case–control association study and gene–environment interactions

(2018) Xin Huang et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

ADGRV1 is implicated in myoclonic epilepsy

(2017) Kenneth A. Myers et al.   EPILEPSIA

A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2 ) increases receptor signaling activity

(2017) Ryan H. Purcell et al.   HUMAN MUTATION

Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification

(2017) Kentaro Inamura   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)

(2017) Shun Lu et al.   PLoS One

Genetic Variant of GPR126 Gene is Functionally Associated With Adolescent Idiopathic Scoliosis in Chinese Population

(2017) Xiaodong Qin et al.   SPINE

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects

(2016) X. Qiao et al.   CLINICAL SCIENCE

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

(2016) Chang Sup Lee et al.   IMMUNITY

Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function

(2016) Pontus Dunér et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning

(2016) Hortensja Ł. Brzóska et al.   KIDNEY INTERNATIONAL

Adhesion G protein-coupled receptors in nervous system development and disease

(2016) Tobias Langenhan et al.   NATURE REVIEWS NEUROSCIENCE

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population

(2016) Jirouta Kitagaki et al.   PLoS One

Feedback regulation of apical progenitor fate by immature neurons through Wnt7–Celsr3–Fzd3 signalling

(2016) Wei Wang et al.   Nature Communications

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

(2016) A Maiga et al.   Blood Cancer Journal

Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita

(2015) Gianina Ravenscroft et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish

(2015) Breanne L Harty et al.   BMC GENOMICS

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Gpr126/Adgrg6deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice

(2015) Courtney M. Karner et al.   HUMAN MOLECULAR GENETICS

Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

(2015) Wataru Kakegawa et al.   NEURON

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

(2015) Yue C. Lu et al.   STRUCTURE

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

(2015) Sarah D. Ackerman et al.   Nature Communications

The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells

(2015) Séverine M. Sigoillot et al.   Cell Reports

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

(2015) Ekaterina Posokhova et al.   Cell Reports

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

(2015) Antje Müller et al.   PLoS Genetics

The eosinophil surface receptor epidermal growth factor–like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders

(2014) Fanny Legrand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

GPR126 Protein Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Receptor Signaling

(2014) Hengxiang Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation

(2014) Parham Solaimani Kartalaei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding cadherin EGF LAG seven-pass G-type receptors

(2014) Xiao-Jing Wang et al.   JOURNAL OF NEUROCHEMISTRY

Identification of Novel CELSR1 Mutations in Spina Bifida

(2014) Yunping Lei et al.   PLoS One

Skeletal Muscle Expression of the Adhesion-GPCR CD97: CD97 Deletion Induces an Abnormal Structure of the Sarcoplasmatic Reticulum but Does Not Impair Skeletal Muscle Function

(2014) Tatiana Zyryanova et al.   PLoS One

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

(2014) N. Hamoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H-Ras forms dimers on membrane surfaces via a protein-protein interface

(2014) W.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Orphan G Protein–Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size

(2013) James P. Bridges et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis

(2013) Massimo Masiero et al.   CANCER CELL

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling

(2013) X. Li et al.   DEVELOPMENT

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle developmentin vivo

(2013) Melissa P. Wu et al.   FEBS Journal

BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas

(2013) Muhammad F Bari et al.   HISTOPATHOLOGY

CD55 Costimulation Induces Differentiation of a Discrete T Regulatory Type 1 Cell Population with a Stable Phenotype

(2013) R. V. Sutavani et al.   JOURNAL OF IMMUNOLOGY

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

(2013) A. Mogha et al.   JOURNAL OF NEUROSCIENCE

G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1

(2013) Günther HS Richter et al.   JOURNAL OF PATHOLOGY

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

(2013) Ikuyo Kou et al.   NATURE GENETICS

Shaping the nervous system: role of the core planar cell polarity genes

(2013) Fadel Tissir et al.   NATURE REVIEWS NEUROSCIENCE

Overexpression of CD97 Confers an Invasive Phenotype in Glioblastoma Cells and Is Associated with Decreased Survival of Glioblastoma Patients

(2013) Michael Safaee et al.   PLoS One

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

(2013) C. Patra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

(2013) Mi Young Yang et al.   Cell Reports

Refining psychiatric phenotypes for response to treatment: Contribution of LPHN3 in ADHD

(2012) Aurelie Labbe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Initial characterization of mice null for Lphn3 , a gene implicated in ADHD and addiction

(2012) Deeann Wallis et al.   BRAIN RESEARCH

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

(2012) Tamako Nishimura et al.   CELL

Evidence for GAL3ST4 mutation as the potential cause of pectus excavatum

(2012) Song Wu et al.   CELL RESEARCH

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human

(2012) E. Korpos et al.   DIABETES

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Signaling property study of adhesion G-protein-coupled receptors

(2012) Jamila Gupte et al.   FEBS LETTERS

Adipose tissue deletion ofGpr116impairs insulin sensitivity through modulation of adipose function

(2012) Tao Nie et al.   FEBS LETTERS

LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy

(2012) Zia Choudhry et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

The ADHD-linked gene Lphn3.1 controls locomotor activity and impulsivity in zebrafish

(2012) M Lange et al.   MOLECULAR PSYCHIATRY

Augmented Cardiac Hypertrophy in Response to Pressure Overload in Mice Lacking ELTD1

(2012) Jinfeng Xiao et al.   PLoS One

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

(2012) Cedric Cortijo et al.   Cell Reports

Neurexins and neuroligins: synapses look out of the nervous system

(2011) Alessia Bottos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gpr126 is essential for peripheral nerve development and myelination in mammals

(2011) K. R. Monk et al.   DEVELOPMENT

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

(2011) Nien-Yi Chiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thy-1 (CD90) Is an Interacting Partner for CD97 on Activated Endothelial Cells

(2011) E. Wandel et al.   JOURNAL OF IMMUNOLOGY

Brain-Specific Angiogenesis Inhibitor 1 is a Putative Factor for Inhibition of Neovascular Formation in Renal Cell Carcinoma

(2011) Toshikazu Izutsu et al.   JOURNAL OF UROLOGY

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

(2011) Soumita Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

(2011) R. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier

(2011) M. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of either CD55 or CD97 ameliorates arthritis in mouse models

(2010) Robert M. Hoek et al.   ARTHRITIS AND RHEUMATISM

Genotype–phenotype relationship in three cases with overlapping 19p13.12 microdeletions

(2010) Maria C Bonaglia et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

(2010) M Arcos-Burgos et al.   MOLECULAR PSYCHIATRY

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule

(2010) Sylvain Pradervand et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse

(2010) Helen Waller-Evans et al.   PLoS One

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

(2009) B. Kaur et al.   CANCER RESEARCH

Latrophilin Signaling Links Anterior-Posterior Tissue Polarity and Oriented Cell Divisions in the C. elegans Embryo

(2009) Tobias Langenhan et al.   DEVELOPMENTAL CELL

Functional Cross-interaction of the Fragments Produced by the Cleavage of Distinct Adhesion G-protein-coupled Receptors

(2009) John-Paul Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protocadherin Gene Celsr3 Is Required for Interneuron Migration in the Mouse Forebrain

(2009) G. Ying et al.   MOLECULAR AND CELLULAR BIOLOGY

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

(2009) K. R. Monk et al.   SCIENCE

Teneurin-1 is expressed in interconnected regions of the developing brain and is processed in vivo

(2008) Daniela Kenzelmann et al.   BMC DEVELOPMENTAL BIOLOGY

Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat

(2008) Tatjana Haitina et al.   BMC NEUROSCIENCE

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR56 Regulates Pial Basement Membrane Integrity and Cortical Lamination

(2008) S. Li et al.   JOURNAL OF NEUROSCIENCE

The Genetics of Symptom-Based Phenotypes: Toward a Molecular Classification of Schizophrenia

(2008) P. DeRosse et al.   SCHIZOPHRENIA BULLETIN

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

(2007) Simon Yona et al.   FASEB JOURNAL