Lysine Malonylation and Its Links to Metabolism and Diseases

Multistage-Responsive Nanocomplexes Attenuate Ulcerative Colitis by Improving the Accumulation and Distribution of Oral Nucleic Acid Drugs in the Colon

(2022) Xiaoxin Li et al.   ACS Applied Materials & Interfaces

The lncRNA Punisher Regulates Apoptosis and Mitochondrial Homeostasis of Vascular Smooth Muscle Cells via Targeting miR-664a-5p and OPA1

(2022) Yanyan Yang et al.   Oxidative Medicine and Cellular Longevity

miR-564: A potential regulator of vascular smooth muscle cells and therapeutic target for aortic dissection

(2022) Min Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

(2021) Yashira L. Negrón Abril et al.   ONCOGENE

Malonyl coenzyme A decarboxylase deficiency with a novel mutation

(2021) Cigdem S. Kasapkara et al.   CARDIOLOGY IN THE YOUNG

Cellular carbon stress is a mediator of obesity-associated osteoarthritis development

(2021) Huanhuan Liu et al.   OSTEOARTHRITIS AND CARTILAGE

Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway

(2021) Linghang Qu et al.   Frontiers in Pharmacology

Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family

(2021) Sarah Snanoudj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deacetylation of Transcription Factors in Carcinogenesis

(2021) Marta Halasa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dihydroartemisinin ameliorates retinal vascular dysfunction in diabetes mellitus via the FASN/Kmal-mTOR/SREBP1 feedback loop

(2021) Chufeng Gu et al.   PHARMACOLOGICAL RESEARCH

5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

(2021) Tingyu Zong et al.   Molecular Therapy-Nucleic Acids

Role of acetylation in doxorubicin-induced cardiotoxicity

(2021) Daisong Li et al.   Redox Biology

Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

(2020) Rong Fu et al.   Nature Communications

Short-chain fatty acid, acylation and cardiovascular diseases

(2020) Xiao-Feng Chen et al.   CLINICAL SCIENCE

Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases

(2020) Min Li et al.   ANGIOGENESIS

Light-driven post-translational installation of reactive protein side chains

(2020) Brian Josephson et al.   NATURE

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy

(2020) Kuan‐Yu Lin et al.   Journal of Diabetes Investigation

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

A comprehensive review and update on ulcerative colitis,

(2019) Mahesh Gajendran et al.   DM DISEASE-A-MONTH

The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of α-crystallin in mouse lenses

(2019) Sandip K. Nandi et al.   EXPERIMENTAL EYE RESEARCH

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

(2019) GuoXiao Wang et al.   MOLECULAR CELL

Atractylodin Suppresses Dendritic Cell Maturation and Ameliorates Collagen-Induced Arthritis in a Mouse Model

(2019) Cheng Hsuan Chuang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Lysine malonylation and propionylation are prevalent in human lens proteins

(2019) Rooban B. Nahomi et al.   EXPERIMENTAL EYE RESEARCH

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

(2018) Yuzhang Du et al.   NUCLEIC ACIDS RESEARCH

Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress

(2018) Alec G. Trub et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size

(2018) Laura Valls-Lacalle et al.   Scientific Reports

OUP accepted manuscript

(2018)   BRIEFINGS IN BIOINFORMATICS

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

Diabetic Retinopathy

(2018) Aris N. Kollias et al.   Deutsches Arzteblatt International

Protein Language: Post-Translational Modifications Talking to Each Other

(2018) Lam Dai Vu et al.   TRENDS IN PLANT SCIENCE

PTMD: A Database of Human Disease-associated Post-translational Modifications

(2018) Haodong Xu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice

(2018) Yipeng Du et al.   EBioMedicine

PLMD: An updated data resource of protein lysine modifications

(2017) Haodong Xu et al.   Journal of Genetics and Genomics

Malonylome Analysis Reveals the Involvement of Lysine Malonylation in Metabolism and Photosynthesis in Cyanobacteria

(2017) Yanyan Ma et al.   JOURNAL OF PROTEOME RESEARCH

The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model

(2017) Litong Nie et al.   MOLECULAR & CELLULAR PROTEOMICS

Post-translational modifications and their applications in eye research

(2017) Bing-Jie Chen et al.   Molecular Medicine Reports

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global substrate specificity profiling of post-translational modifying enzymes

(2017) Sam L. Ivry et al.   PROTEIN SCIENCE

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development

(2017) Laure-Anne Teuwen et al.   DEVELOPMENTAL BIOLOGY

Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis

(2016) Ronald K. June et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lysine Malonylome May Affect the Central Metabolism and Erythromycin Biosynthesis Pathway in Saccharopolyspora erythraea

(2016) Jun-Yu Xu et al.   JOURNAL OF PROTEOME RESEARCH

Global Profiling of Protein Lysine Malonylation in Escherichia coli Reveals Its Role in Energy Metabolism

(2016) Lili Qian et al.   JOURNAL OF PROTEOME RESEARCH

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carnitine palmitoyltransferase 1C: From cognition to cancer

(2016) Núria Casals et al.   PROGRESS IN LIPID RESEARCH

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

(2015) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

(2015) Matthew D. Hirschey et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle

(2014) Susana Rodriguez et al.   BMC BIOCHEMISTRY

Malonyl CoA: A promising target for the treatment of cardiac disease

(2014) Natasha Fillmore et al.   IUBMB LIFE

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

(2014) Olga Pougovkina et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins

(2014) Yipeng Du et al.   MOLECULAR & CELLULAR PROTEOMICS

Post-translational modifications of intermediate filament proteins: mechanisms and functions

(2014) Natasha T. Snider et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

(2014) Weidong Lu et al.   TUMOR BIOLOGY

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

(2014) Keren Yizhak et al.   eLife

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

(2013) Waleed G.T. Masoud et al.   CARDIOVASCULAR RESEARCH

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

(2012) John R. Ussher et al.   CARDIOVASCULAR RESEARCH

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Dietary Fat and Heart Failure: Moving From Lipotoxicity to Lipoprotection

(2012) William C. Stanley et al.   CIRCULATION RESEARCH

Epigenetic Control of Angiogenesis via DNA Methylation

(2011) Marcus P. Cooper et al.   CIRCULATION

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity

(2010) Michael J. Wolfgang et al.   FEBS Journal

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Exercise therapy in Type 2 diabetes

(2009) Stephan F. E. Praet et al.   ACTA DIABETOLOGICA

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase

(2009) J. R. Ussher et al.   DIABETES

High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency

(2009) Clifford D.L. Folmes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats by reducing malonyl-CoA levels in the liver and skeletal muscle

(2009) Zhengshan Zhao et al.   LIFE SCIENCES

Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells

(2009) W Zhou et al.   ONCOGENE

Transduction of Redox Signaling by Electrophile-Protein Reactions

(2009) T. K. Rudolph et al.   Science Signaling

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

(2008) David Saggerson   Annual Review of Nutrition

The malonyl CoA axis as a potential target for treating ischaemic heart disease

(2008) J. R. Ussher et al.   CARDIOVASCULAR RESEARCH