Dihydroartemisinin ameliorates retinal vascular dysfunction in diabetes mellitus via the FASN/Kmal-mTOR/SREBP1 feedback loop

Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance

(2020) Yueyang Zhao et al.   Frontiers in Aging Neuroscience

Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway

(2020) Yingjun Zhu et al.   Frontiers in Pharmacology

Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice

(2020) Wei Fu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Dihydroartemisinin alleviates high glucose-induced vascular smooth muscle cells proliferation and inflammation by depressing the miR-376b-3p/KLF15 pathway

(2020) Bingqi Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carbohydrate response element‐binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy

(2020) Nan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Artesunate induces apoptosis and inhibits the proliferation, stemness, and tumorigenesis of leukemia

(2020) Shengmei Chen et al.   Annals of Translational Medicine

Comprehensive analysis of angiogenesis-related genes and pathways in early diabetic retinopathy

(2020) Chufeng Gu et al.   BMC Medical Genomics

Lipid metabolism dysregulation in diabetic retinopathy

(2020) Julia V. Busik   JOURNAL OF LIPID RESEARCH

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

Artemisinin inhibits angiogenesis by regulating p38 MAPK/CREB/TSP-1 signaling pathway in osteosarcoma

(2019) Zhi Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Diabetic Retinopathy: Pathophysiology and Treatments

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Incidence and progression of diabetic retinopathy: a systematic review

(2018) Charumathi Sabanayagam et al.   Lancet Diabetes & Endocrinology

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium

(2018) Qingqiu Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aralia elata (Miq) Seem Extract Decreases O-GlcNAc Transferase Expression and Retinal Cell Death in Diabetic Mice

(2017) Yoon Sook Kim et al.   JOURNAL OF MEDICINAL FOOD

The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model

(2017) Litong Nie et al.   MOLECULAR & CELLULAR PROTEOMICS

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function

(2016) Ping Lu et al.   CELL RESEARCH

TargetNet: a web service for predicting potential drug–target interaction profiling via multi-target SAR models

(2016) Zhi-Jiang Yao et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The eukaryotic promoter database in its 30th year: focus on non-vertebrate organisms

(2016) René Dreos et al.   NUCLEIC ACIDS RESEARCH

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

(2015) Matthew D. Hirschey et al.   MOLECULAR & CELLULAR PROTEOMICS

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis

(2015) Da Eun Jeong et al.   Oncotarget

Epigenetic mechanisms in diabetic complications and metabolic memory

(2014) Marpadga A. Reddy et al.   DIABETOLOGIA

Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins

(2014) Yipeng Du et al.   MOLECULAR & CELLULAR PROTEOMICS

Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo

(2012) Chris Zhiyi Zhang et al.   BIOCHEMICAL PHARMACOLOGY

The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

(2012) F Seguin et al.   BRITISH JOURNAL OF CANCER

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Computational Tool for Quantitative Analysis of Vascular Networks

(2011) Enrique Zudaire et al.   PLoS One

Resveratrol Inhibits Neuronal Apoptosis and Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Mouse Retina

(2010) Y.-H. Kim et al.   DIABETES

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer

(2009) J. A. Menendez et al.   CLINICAL CHEMISTRY

Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy

(2009) Faten Abdulhady Zakareia et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS