Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

(2014) Olga Pougovkina et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

SIRT3: As Simple As It Seems?

(2013) David B. Lombard et al.   GERONTOLOGY

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin family’s role in aging and age-associated pathologies

(2013) Jessica A. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB inEscherichia coli

(2013) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

Mechanistic insights into the regulation of metabolic enzymes by acetylation

(2012) Yue Xiong et al.   JOURNAL OF CELL BIOLOGY

Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways

(2012) Yue Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases

(2011) Matthew D. Hirschey   Cell Metabolism

Mammalian ACSF3 Protein Is a Malonyl-CoA Synthetase That Supplies the Chain Extender Units for Mitochondrial Fatty Acid Synthesis

(2011) Andrzej Witkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

SIRT3 Substrate Specificity Determined by Peptide Arrays and Machine Learning

(2010) Brian C. Smith et al.   ACS Chemical Biology

Mitochondrial sirtuins

(2010) Jing-Yi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity

(2010) Michael J. Wolfgang et al.   FEBS Journal

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Disorders caused by deficiency of succinate-CoA ligase

(2008) E. Ostergaard   JOURNAL OF INHERITED METABOLIC DISEASE

Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification inEscherichia Coli

(2008) Junmei Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS