Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection

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Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

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A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection

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SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

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A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids

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Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

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A molecular single-cell lung atlas of lethal COVID-19

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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

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The spatial landscape of lung pathology during COVID-19 progression

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COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

(2021) Guilherme Dias de Melo et al.   Science Translational Medicine

Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

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Mapping the human genetic architecture of COVID-19

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Dysregulation of brain and choroid plexus cell types in severe COVID-19

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Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

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Anti–SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

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Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

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Genomewide Association Study of Severe Covid-19 with Respiratory Failure

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A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

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Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

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Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

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Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

(2020) Hannah Peckham et al.   Nature Communications

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain

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Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

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