Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

(2021) Lee Makowski et al.   Viruses-Basel

Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19

(2021) Damir Bojadzic et al.   Frontiers in Pharmacology

Lessons learned: new insights on the role of cytokines in COVID-19

(2021) Maja Buszko et al.   NATURE IMMUNOLOGY

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

(2021) Eun Jeong Park et al.   Viruses-Basel

Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein–Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2

(2021) Damir Bojadzic et al.   ACS Infectious Diseases

Structural insights into integrin α5β1 opening by fibronectin ligand

(2021) Stephanie Schumacher et al.   Science Advances

Role of host factors in SARS-CoV-2 entry

(2021) John P. Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19

(2021) Danielle Nader et al.   PLoS One

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

(2021) Maritza Puray-Chavez et al.   Cell Reports

SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells

(2021) Francesca Caccuri et al.   Microorganisms

Low incidence rate of diarrhoea in COVID-19 patients is due to integrin

(2021) Shan Gao et al.   JOURNAL OF INFECTION

Integrin activation is an essential component of SARS-CoV-2 infection

(2021) Peter Simons et al.   Scientific Reports

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A potential role for integrins in host cell entry by SARS-CoV-2

(2020) Christian JA Sigrist et al.   ANTIVIRAL RESEARCH

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

(2020) Francesca Coperchini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2

(2020) Junwen Luan et al.   JOURNAL OF INFECTION

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection

(2020) Shijia Yan et al.   Frontiers in Pharmacology

Identification of required host factors for SARS-CoV-2 infection in human cells

(2020) Zharko Daniloski et al.   CELL

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

The role of integrins in inflammation and angiogenesis

(2020) Olachi J. Mezu-Ndubuisi et al.   PEDIATRIC RESEARCH

Integrins Control Vesicular Trafficking; New Tricks for Old Dogs

(2020) Martijn A. Nolte et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

Virus–Receptor Interactions: The Key to Cellular Invasion

(2018) Melissa S. Maginnis   JOURNAL OF MOLECULAR BIOLOGY

Pleiotrophin, a multifunctional cytokine and growth factor, induces leukocyte responses through the integrin Mac-1

(2017) Di Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

(2017) Abhay Kotecha et al.   Nature Communications

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

(2017) Tobias G. Kapp et al.   Scientific Reports

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY