A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Ex Vivo Expanded 3D Human Kidney Spheres Engraft Long Term and Repair Chronic Renal Injury in Mice

(2020) Orit Harari-Steinberg et al.   Cell Reports

An update on ACE2 amplification and its therapeutic potential

(2020) Alonso Marquez et al.   Acta Physiologica

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

(2020) Young-Il Kim et al.   Cell Host & Microbe

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

(2020) Daniel Batlle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

(2020) Hua Su et al.   KIDNEY INTERNATIONAL

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks

(2020) Markus Blaess et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL1 High-Risk Genotype

(2020) Huijuan Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids

(2020) Ashwani Kumar Gupta et al.   Communications Biology

Higher mortality of COVID-19 in males: Sex differences in immune response and cardiovascular comorbidities

(2020) Laura A Bienvenu et al.   CARDIOVASCULAR RESEARCH

Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Human recombinant soluble ACE2 in severe COVID-19

(2020) Alexander Zoufaly et al.   Lancet Respiratory Medicine

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent

(2019) Peter Serfozo et al.   HYPERTENSION

Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System

(2019) Jan Wysocki et al.   Biomolecules

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation

(2018) Pan Liu et al.   KIDNEY INTERNATIONAL

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13

(2017) Pan Liu et al.   Scientific Reports

Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells

(2016) Ryuji Morizane et al.   Nature Protocols

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Angiotensin-Converting Enzyme 2–Independent Action of Presumed Angiotensin-Converting Enzyme 2 Activators

(2014) Philipp K. Haber et al.   HYPERTENSION

Update on the Angiotensin Converting Enzyme 2-Angiotensin (1–7)-Mas Receptor Axis: Fetal Programing, Sex Differences, and Intracellular Pathways

(2014) Mark C. Chappell et al.   Frontiers in Endocrinology

Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects

(2013) Manuel Haschke et al.   CLINICAL PHARMACOKINETICS

Murine Recombinant Angiotensin-Converting Enzyme 2

(2012) Minghao Ye et al.   HYPERTENSION

Recombinant Expression and Characterization of Human and Murine ACE2: Species-Specific Activation of the Alternative Renin-Angiotensin-System

(2012) Marko Poglitsch et al.   International Journal of Hypertension

Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy

(2011) Daniel Batlle et al.   KIDNEY INTERNATIONAL

ACE2: more of Ang-(1–7) or less Ang II?

(2010) Carlos M Ferrario   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2

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