SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

Neuroinvasion of SARS-CoV-2 in human and mouse brain

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Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids

(2021) Shashi Kant Tiwari et al.   Stem Cell Reports

Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery

(2021) Alice Maria Giani et al.   Stem Cell Research

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

(2021) Mona Khan et al.   CELL

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

(2020) Zhe Zhu et al.   Cell Stem Cell

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

(2020) Abdo A. Elfiky   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

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FATCAT 2.0: towards a better understanding of the structural diversity of proteins

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Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19

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Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review

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Neurobiology of COVID-19

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New insights into the neurological effects of COVID-19

(2020) Heather Wood   Nature Reviews Neurology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

(2020) Fernanda G. De Felice et al.   TRENDS IN NEUROSCIENCES

Transplacental transmission of SARS-CoV-2 infection

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Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic

(2020) Rodrigo Jácome et al.   Scientific Reports

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester

(2020) Bailey A. T. Weatherbee et al.   Open Biology

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

(2020) David H. Brann et al.   Science Advances

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

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SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

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SARS ‐CoV‐2 targets neurons of 3D human brain organoids

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Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir

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Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

(2019) Jason W. Adams et al.   PHYSIOLOGY

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

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Blocking Zika virus vertical transmission

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InterPro in 2019: improving coverage, classification and access to protein sequence annotations

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WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research

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The Reactome Pathway Knowledgebase

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Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae

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Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis

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Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

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Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

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Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir

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The discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C

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Tissue-based map of the human proteome

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HTSeq--a Python framework to work with high-throughput sequencing data

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Causal analysis approaches in Ingenuity Pathway Analysis

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The Genotype-Tissue Expression (GTEx) project

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Molecular Modeling Comparison of the Performance of NS5b Polymerase Inhibitor (PSI-7977) on Prevalent HCV Genotypes

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STAR: ultrafast universal RNA-seq aligner

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Molecular signatures database (MSigDB) 3.0

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

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