A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

(2022) Dhiraj Mannar et al.   SCIENCE

TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation

(2021) Christopher L. Moore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID‐19 disease

(2021) Emad E. Khoury et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids

(2021) Jan Wysocki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sixteen novel lineages of SARS-CoV-2 in South Africa

(2021) Houriiyah Tegally et al.   NATURE MEDICINE

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

(2021) Kui K. Chan et al.   Science Advances

Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19

(2021) Luise Hassler et al.   Clinical Journal of the American Society of Nephrology

High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19 Outcome

(2021) Paulo Caceres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19

(2021) Zhenhua Li et al.   Nature Nanotechnology

Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2

(2021) Yusuke Higuchi et al.   Nature Communications

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

(2021) Markus Hoffmann et al.   CELL

Elevated Neutrophil Gelatinase-Associated Lipocalin Is Associated With the Severity of Kidney Injury and Poor Prognosis of Patients With COVID-19

(2021) Katherine Xu et al.   Kidney International Reports

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Covid-19 infection and mortality: a physiologist’s perspective enlightening clinical features and plausible interventional strategies

(2020) Zaid A. Abassi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

(2020) Daniel Batlle et al.   CLINICAL SCIENCE

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

(2020) Daniel Batlle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia

(2020) Guangchang Pei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute kidney injury in patients hospitalized with COVID-19

(2020) Jamie S. Hirsch et al.   KIDNEY INTERNATIONAL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FcγR Binding and ADCC Activity of Human IgG Allotypes

(2020) Steven W. de Taeye et al.   Frontiers in Immunology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection

(2020) Gregory Brett Moreau et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings

(2020) Purva Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AKI in Hospitalized Patients with and without COVID-19: A Comparison Study

(2020) Molly Fisher et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney and Lung ACE2 Expression after an ACE Inhibitor or an Ang II Receptor Blocker: Implications for COVID-19

(2020) Jan Wysocki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL1 High-Risk Genotype

(2020) Huijuan Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

(2020) Kui K. Chan et al.   SCIENCE

The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?

(2020) Zaid Abassi et al.   Frontiers in Immunology

Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria

(2020) Shreeram Akilesh et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

SARS-CoV-2 and Three Related Coronaviruses Utilize Multiple ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig

(2020) Yujun Li et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

(2020) Anum Glasgow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

(2020) Raveen Rathnasinghe et al.   Emerging Microbes & Infections

ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle

(2020) Zaid Abassi et al.   Frontiers in Physiology

Human recombinant soluble ACE2 in severe COVID-19

(2020) Alexander Zoufaly et al.   Lancet Respiratory Medicine

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

(2020) Joseph W. Golden et al.   JCI Insight

Emergence of a new SARS-CoV-2 variant in the UK

(2020) Julian W Tang et al.   JOURNAL OF INFECTION

Emergence of a Highly Fit SARS-CoV-2 Variant

(2020) Ralph S. Baric   NEW ENGLAND JOURNAL OF MEDICINE

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

(2020) Fatai S. Oladunni et al.   Nature Communications

An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

(2020) Takuya Tada et al.   Cell Reports

IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase associated lipocalin during acute kidney injury

(2019) Nataliya I. Skrypnyk et al.   KIDNEY INTERNATIONAL

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent

(2019) Peter Serfozo et al.   HYPERTENSION

Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System

(2019) Jan Wysocki et al.   Biomolecules

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity

(2018) Andreas Schrimpf et al.   BIOCHEMISTRY

Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation

(2018) Pan Liu et al.   KIDNEY INTERNATIONAL

Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy

(2017) Jan Wysocki et al.   KIDNEY INTERNATIONAL

Neutrophil gelatinase-associated lipocalin as a potential novel biomarker for ventilator-associated lung injury

(2017) Rui Xiao et al.   Molecular Medicine Reports

Kidney injury molecule-1 staining in renal allograft biopsies 10 days after transplantation is inversely correlated with functioning proximal tubular epithelial cells

(2017) Jonna R Bank et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nanobodies as therapeutics: big opportunities for small antibodies

(2016) Sophie Steeland et al.   DRUG DISCOVERY TODAY

Transcriptional and Translational Modulation ofmyo-Inositol Oxygenase (Miox) by Fatty Acids

(2015) Tatsuya Tominaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Recombinant Angiotensin-Converting Enzyme 2

(2012) Minghao Ye et al.   HYPERTENSION

The Ngal reporter mouse detects the response of the kidney to injury in real time

(2011) Neal Paragas et al.   NATURE MEDICINE

Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2

(2009) Jan Wysocki et al.   HYPERTENSION