Ferroptosis: mechanisms and advances in ocular diseases

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD

(2022) Urvi Gupta et al.   Autophagy

Induction of autophagy-dependent ferroptosis to eliminate drug-tolerant human retinoblastoma cells

(2022) Ke Liu et al.   Cell Death & Disease

Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy

(2022) Caiying Liu et al.   Redox Biology

Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

(2022) Fei Yao et al.   CELL DEATH AND DIFFERENTIATION

Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury

(2022) Yangyang Li et al.   Journal of Neuroinflammation

Aging lens epithelium is susceptible to ferroptosis

(2021) Zongbo Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia

(2021) Yingrui Liu et al.   AGING CELL

Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells

(2021) Wataru Otsu et al.   Scientific Reports

Ferroptosis: Final destination for cancer?

(2020) Zeng Ye et al.   CELL PROLIFERATION

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis

(2020) Jing-Jie Peng et al.   EXPERIMENTAL EYE RESEARCH

Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis—A Novel Form of Non-Apoptotic Cell Death?

(2020) Ricardo U. Macías-Rodríguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Nrf2 activator MIND4‐17 protects retinal ganglion cells from high glucose‐induced oxidative injury

(2020) Nan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

DJ-1 protects retinal pericytes against high glucose-induced oxidative stress through the Nrf2 signaling pathway

(2020) Wanpeng Wang et al.   Scientific Reports

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

(2020) Yunpeng Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis in Liver Diseases: An Overview

(2020) Martina Maria Capelletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Abnormal Ferroptosis in Myelodysplastic Syndrome

(2020) Qi Lv et al.   Frontiers in Oncology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Mitochondrial iron metabolism and its role in diseases

(2020) Jiayin Gao et al.   CLINICA CHIMICA ACTA

Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis

(2019) Riccardo Cheloni et al.   BMJ Open

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina

(2019) Mohammad Shamsul Ola et al.   NEUROTOXICITY RESEARCH

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

(2019) Cristina Florean et al.   FREE RADICAL BIOLOGY AND MEDICINE

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

The Relationship between Ferroptosis and Tumors - A Novel Landscape for Therapeutic Approach

(2019) Xiaojun Xia et al.   CURRENT GENE THERAPY

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

(2019) Shu-Wing Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells

(2019) Jong-Jer Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update

(2019) The Hong Phong Nguyen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model

(2019) Iván Millán et al.   Nutrients

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

The relation between dietary intake and glaucoma: a systematic review

(2018) Wishal D. Ramdas   ACTA OPHTHALMOLOGICA

Emerging Strategies of Cancer Therapy Based on Ferroptosis

(2018) Zheyu Shen et al.   ADVANCED MATERIALS

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

To eat or not to eat — the metabolic flavor of ferroptosis

(2018) Minghui Gao et al.   CURRENT OPINION IN CELL BIOLOGY

Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina

(2018) Kenji Sakamoto et al.   EXPERIMENTAL EYE RESEARCH

Age-Related Macular Degeneration: New Paradigms for Treatment and Management of AMD

(2018) Luis Fernando Hernández-Zimbrón et al.   Oxidative Medicine and Cellular Longevity

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Haemochromatosis

(2018) Pierre Brissot et al.   Nature Reviews Disease Primers

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells

(2018) Kiyohito Totsuka et al.   EXPERIMENTAL EYE RESEARCH

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of ferroptosis in hepatocellular carcinoma

(2018) Jianhua Nie et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

The α6β4 integrin promotes resistance to ferroptosis

(2017) Caitlin W. Brown et al.   JOURNAL OF CELL BIOLOGY

Crocin Inhibits Oxidative Stress and Pro-inflammatory Response of Microglial Cells Associated with Diabetic Retinopathy Through the Activation of PI3K/Akt Signaling Pathway

(2017) Xinguang Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events

(2017) Robert L. Bertrand   MEDICAL HYPOTHESES

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Iron and cancer: recent insights

(2016) David H. Manz et al.   Annals of the New York Academy of Sciences

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN JOURNAL OF HEART FAILURE

Screening for Impaired Visual Acuity in Older Adults

(2016) Roger Chou et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy

(2016) Bowen Ke et al.   MEDICINAL RESEARCH REVIEWS

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE PHYSIOLOGY OF THE RETINAL PIGMENT EPITHELIUM IN DANON DISEASE

(2016) Dorothy A. Thompson et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells

(2016) Osamu Sakai et al.   FEBS Open Bio

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms

(2015) Elena Gammella et al.   Oxidative Medicine and Cellular Longevity

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Chemistry of the Retinoid (Visual) Cycle

(2013) Philip D. Kiser et al.   CHEMICAL REVIEWS

Danon disease

(2013) J. He et al.   HERZ

Retinal iron homeostasis in health and disease

(2013) Delu Song et al.   Frontiers in Aging Neuroscience

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina

(2012) Delu Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Retinal Photodamage Mediated by All-trans-retinal†

(2012) Tadao Maeda et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa

(2011) Alexey Obolensky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment

(2011) Shinichi Usui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration

(2011) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulatory profiling identifies mechanisms of small molecule-induced cell death

(2011) A. J. Wolpaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Expression of Glutathione Peroxidase 4 Strongly Protects Retina from Oxidative Damage

(2008) Lili Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Retinopathy in Mice Induced by Disrupted All-trans-retinal Clearance

(2008) Akiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY