Age-Related Macular Degeneration: New Paradigms for Treatment and Management of AMD

Aflibercept in age-related macular degeneration: evaluating its role as a primary therapeutic option

(2017) M Ashraf et al.   EYE

Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration

(2017) Lysann Wagner et al.   GLIA

Effect of (R)-α-Lipoic Acid Supplementation on Serum Lipids and Antioxidative Ability in Patients with Age-Related Macular Degeneration

(2017) Ying-Dong Sun et al.   ANNALS OF NUTRITION AND METABOLISM

Inflammation and its role in age-related macular degeneration

(2016) Anu Kauppinen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy in acute brain injury

(2016) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

(2016) Jian Liu et al.   Scientific Reports

Nutritional supplements in age-related macular degeneration

(2015) Doreen Schmidl et al.   ACTA OPHTHALMOLOGICA

Current therapeutic developments in atrophic age-related macular degeneration

(2015) Jakub Hanus et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Dementia of the eye: the role of amyloid beta in retinal degeneration

(2015) J A Ratnayaka et al.   EYE

Age-dependent Müller glia neurogenic competence in the mouse retina

(2015) Kati Löffler et al.   GLIA

Protective Effects of Resveratrol against UVA-Induced Damage in ARPE19 Cells

(2015) Chi-Ming Chan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

(2015) Steven D Schwartz et al.   LANCET

Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases

(2015) Irina Milisav et al.   MOLECULES

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Silencing Matrix Metalloproteinases 9 and 2 Inhibits Human Retinal Microvascular Endothelial Cell Invasion and Migration

(2015) Yonghao Gu et al.   OPHTHALMIC RESEARCH

Stem cell therapies for age-related macular degeneration: the past, present, and future

(2015) Yalong Dang et al.   Clinical Interventions in Aging

Age-Related Macular Degeneration: Advances in Management and Diagnosis

(2015) Yoshihiro Yonekawa et al.   Journal of Clinical Medicine

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Reactive microglia and macrophage facilitate the formation of Müller glia-derived retinal progenitors

(2014) Andy J. Fischer et al.   GLIA

Resveratrol and the eye: activity and molecular mechanisms

(2014) Christina Bola et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Resveratrol prevents the development of choroidal neovascularization by modulating AMP-activated protein kinase in macrophages and other cell types

(2014) Norihiro Nagai et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol Based Oral Nutritional Supplement Produces Long-Term Beneficial Effects on Structure and Visual Function in Human Patients

(2014) Stuart Richer et al.   Nutrients

Transplantation of Photoreceptors Derived From Human Müller Glia Restore Rod Function in the P23H Rat

(2014) Hari Jayaram et al.   Stem Cells Translational Medicine

Trehalose-Based Eye Drops Preserve Viability and Functionality of Cultured Human Corneal Epithelial Cells during Desiccation

(2014) Aneta Hill-Bator et al.   Biomed Research International

Effect of Long-Chain ω-3 Fatty Acids and Lutein + Zeaxanthin Supplements on Cardiovascular Outcomes

(2014) Denise E. Bonds et al.   JAMA Internal Medicine

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

(2014) Hiroyuki Kamao et al.   Stem Cell Reports

ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors

(2013) J. Pollak et al.   DEVELOPMENT

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

CURRENT KNOWLEDGE AND TRENDS IN AGE-RELATED MACULAR DEGENERATION

(2013) Raul Velez-Montoya et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Wnt/β-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina

(2013) Daniela Sanges et al.   Cell Reports

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Mechanism of Inflammation in Age-Related Macular Degeneration

(2012) Francesco Parmeggiani et al.   MEDIATORS OF INFLAMMATION

How does the macula protect itself from oxidative stress?

(2012) James T. Handa   MOLECULAR ASPECTS OF MEDICINE

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

Functions of microglia in the central nervous system – beyond the immune response

(2012) Hiroaki Wake et al.   Neuron Glia Biology

The Reactivity, Distribution and Abundance of Non-Astrocytic Inner Retinal Glial (NIRG) Cells Are Regulated by Microglia, Acute Damage, and IGF1

(2012) Christopher P. Zelinka et al.   PLoS One

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids

(2012) P. X. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CURRENT KNOWLEDGE AND TRENDS IN AGE-RELATED MACULAR DEGENERATION

(2012) Raul Velez-Montoya et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Generation of retinal pigment epithelial cells from human embryonic stem cell-derived spherical neural masses

(2012) Myung Soo Cho et al.   Stem Cell Research

Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration

(2012) Lai Wei et al.   Cell Reports

Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration

(2012) Silke Becker et al.   Cells

Assessing Susceptibility to Age-Related Macular Degeneration With Genetic Markers and Environmental Factors

(2011) Yuhong Chen   ARCHIVES OF OPHTHALMOLOGY

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

(2011) Violetta Soura et al.   BIOCHEMICAL JOURNAL

Oxysterol Derivatives of Cholesterol in Neurodegenerative Disorders

(2011) T. M. Jeitner et al.   CURRENT MEDICINAL CHEMISTRY

Chrysin Protects Epidermal Keratinocytes from UVA- and UVB-Induced Damage

(2011) Nan-Lin Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina

(2011) Minhua Wang et al.   Journal of Neuroinflammation

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

(2011) W. Liu et al.   LIFE SCIENCES

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Müller Glial Cells in Retinal Disease

(2011) Andreas Bringmann et al.   OPHTHALMOLOGICA

Macrophage polarization in the maculae of age-related macular degeneration: A pilot study

(2011) Xiaoguang Cao et al.   PATHOLOGY INTERNATIONAL

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Human Induced Pluripotent Stem-Derived Retinal Pigment Epithelium (RPE) Cells Exhibit Ion Transport, Membrane Potential, Polarized Vascular Endothelial Growth Factor Secretion, and Gene Expression Pattern Similar to Native RPE

(2011) Maria Kokkinaki et al.   STEM CELLS

Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study

(2010) C. I. Falkner-Radler et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

Implications of altered iron homeostasis for age-related macular degeneration

(2010) Janusz Blasiak   Frontiers in Bioscience-Landmark

Microglia in the healthy and degenerating retina: Insights from novel mouse models

(2010) Marcus Karlstetter et al.   IMMUNOBIOLOGY

Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages

(2010) Yasukazu Saitoh et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Astrogliosis in CNS Pathologies: Is There A Role for Microglia?

(2010) Dan Zhang et al.   MOLECULAR NEUROBIOLOGY

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Notch and Wnt Signaling Mediated Rod Photoreceptor Regeneration by Müller Cells in Adult Mammalian Retina

(2010) Carolina Beltrame Del Debbio et al.   PLoS One

Adult Human Müller Glia Cells Are a Highly Efficient Source of Rod Photoreceptors

(2010) Serena G. Giannelli et al.   STEM CELLS

Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential

(2009) Annalisa Buffo et al.   BIOCHEMICAL PHARMACOLOGY

The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration

(2009) Norman B Javitt et al.   CURRENT OPINION IN OPHTHALMOLOGY

Oxidative stress promotes ocular neovascularization

(2009) Aling Dong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Targeting the Wnt Pathway and Transplantation Therapy as Strategies for Retinal Repair

(2009) Fumitaka Osakada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat

(2009) Amanda-Jayne Carr et al.   PLoS One

Development and neurogenic potential of Müller glial cells in the vertebrate retina

(2009) Ashutosh P. Jadhav et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

(2009) Andreas Bringmann et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Para-inflammation in the aging retina

(2009) Heping Xu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells

(2009) David E. Buchholz et al.   STEM CELLS

Reduction of Endogenous Angiogenesis Inhibitors in Bruch's Membrane of the Submacular Region in Eyes With Age-Related Macular Degeneration

(2008) Imran A. Bhutto   ARCHIVES OF OPHTHALMOLOGY

Ex Vivo Dynamic Imaging of Retinal Microglia Using Time-Lapse Confocal Microscopy

(2008) J. E. Lee et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The transcriptome of retinal Müller glial cells

(2008) Karin Roesch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Oxidative damage–induced inflammation initiates age-related macular degeneration

(2008) Joe G Hollyfield et al.   NATURE MEDICINE