Abnormal Ferroptosis in Myelodysplastic Syndrome

Myelodysplastic syndrome patient-derived xenografts: from no options to many

(2020) Christophe Côme et al.   HAEMATOLOGICA

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

(2018) Monique F. Smeets et al.   BLOOD

Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS

(2018) Bani Bandana Ganguly et al.   BLOOD CELLS MOLECULES AND DISEASES

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice

(2018) Xin Jin et al.   HAEMATOLOGICA

Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice

(2018) Xin Jin et al.   HAEMATOLOGICA

The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells

(2018) Ding Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

Immunological effects of hypomethylating agents

(2017) Katherine E. Lindblad et al.   Expert Review of Hematology

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

(2016) Esther A. Obeng et al.   CANCER CELL

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Effects of Iron Overload on the Bone Marrow Microenvironment in Mice

(2015) Yuchen Zhang et al.   PLoS One

Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome

(2014) N. Shenoy et al.   BLOOD

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

(2014) A. Mayle et al.   BLOOD

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Decitabine Induces Delayed Reactive Oxygen Species (ROS) Accumulation in Leukemia Cells and Induces the Expression of ROS Generating Enzymes

(2014) Tamer E. Fandy et al.   CLINICAL CANCER RESEARCH

Why methylation is not a marker predictive of response to hypomethylating agents

(2014) M. T. Voso et al.   HAEMATOLOGICA

Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts

(2014) Valeria Visconte et al.   Journal of Hematology & Oncology

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Demethylation demystification

(2013) L. Suarez et al.   BLOOD

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

(2013) Tomoya Muto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

(2013) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Modulatory profiling identifies mechanisms of small molecule-induced cell death

(2011) A. J. Wolpaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of a leukaemic cell line from a patient with acquisition of chromosomal abnormalities during disease progression in myelodysplastic syndrome

(2010) Toshitaro Nakagawa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure

(2010) Olivier Boutaud et al.   FREE RADICAL BIOLOGY AND MEDICINE

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY